Protein Alignment brm and SMARCAL1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 158/669 - (23%)
• Similarity: 269/669 - (40%)
• Gaps: 152/669 - (22%)

  Fly   727 EDAKDLITKAK----VEDDEYRTE---------EQTYYSIAHTIHEKVVEQASIMVNGTLKEYQI 778
            |:...||.|.:    |:.|...|.         ::|..|:...:.|..:.:....:...|..:|.
Human   377 EEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQR 441

  Fly   779 KGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEK 843
            .|:.:.::.....|   |||:||||||||.|.:..:.  ||:  .|.|::||.|....|...|.:
Human   442 AGVNFAIAKGGRLL---LADDMGLGKTIQAICIAAFY--RKE--WPLLVVVPSSVRFTWEQAFLR 499

  Fly   844 WAPAVG------VVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEG 902
            |.|::.      ||:.|.     ||....:....|: ||:..|..:       |..:|.:||||.
Human   500 WLPSLSPDCINVVVTGKD-----RLTAGLINIVSFD-LLSKLEKQL-------KTPFKVVIIDES 551

  Fly   903 HRMKNH---HCKLTQ-VLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE---- 959
            |.:||.   .|:... ||.   :|...:||:|||..::..||:..:..:.|:.|.....|.
Human   552 HFLKNSRTARCRAAMPVLK---VAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYC 613

  Fly   960 -------QWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKC 1017
                   .|..:..:..|| ::|..||.:             :|||||.:|..|||.|...|:
Human   614 DAKRMPWGWDYSGSSNLGE-LKLLLEEAV-------------MLRRLKSDVLSQLPAKQRKIV-- 662

  Fly  1018 DMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHT 1082
             :.|..|:   :.:::..|  |.:.|....|...|......:.|       |..:..|.|.
Human   663 -VIAPGRI---NARTRAAL--DAAAKEMTTKDKTKQQQKDALIL-------FFNRTAEAKI---- 710

  Fly  1083 GGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGT 1147
                    |         .:::.||..|::...:.|:|......:..|...|..:...::|:||:
Human   711 --------P---------SVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGS 758

  Fly  1148 TKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIG 1212
            |.:.:|.:|.::|....... |.:||..|..:||...:||.||..:..|||...:||:||.||||
Human   759 TSSAEREDLCQQFQLSERHA-VAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIG 822

  Fly  1213 QRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGM----FDQKSTGSERQQFLQTILHQDD 1273
            |.:.|.:..|:...:.::.:....:.|:.:   :.:||:    |.:.:..::       .|::|
Human   823 QTSSVGIHYLVAKGTADDYLWPLIQEKIKV---LAEAGLSETNFSEMTESTD-------YLYKD- 876

  Fly  1274 NEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRER------------LIDE 1326
                     |..:.|..:..:|.|:    :..|.|..:..|...||...            .:||
Human   877 ---------PKQQKIYDLFQKSFEK----EGSDMELLEAAESFDPGSASGTSGSSSQNMGDTLDE 928

  Fly  1327 SELPDWLTKDDDEVERFHY 1345
            |.    ||....:..||.:
Human   929 SS----LTASPQKKRRFEF 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	153/653 (23%)
		Bromo_SNF2L2	1425..1530	CDD:99947
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166
		HARP	343..397	CDD:462166	6/19 (32%)
		HepA	<423..856	CDD:440319	127/509 (25%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	66/245 (27%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		8/33 (24%)