DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brm and smarca4

DIOPT Version :9

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_001362194.1 Gene:smarca4 / 496545 XenbaseID:XB-GENE-483983 Length:1599 Species:Xenopus tropicalis


Alignment Length:1728 Identity:906/1728 - (52%)
Similarity:1112/1728 - (64%) Gaps:237/1728 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASPSP--ANSPMPPPQ---APSPMAPPSQSPAPSPHSPYPHQQPGPLQGPP-PPGHPGAYGHPM 59
            |::|.|  ..:|.|.|.   .|||.|....||.|||.|  .|...||..||| ||          
 Frog     1 MSTPDPPMGGTPRPVPSPGPGPSPGAMLGPSPGPSPGS--AHSMMGPSPGPPIPP---------- 53

  Fly    60 QHGPPGQGPPGHHM----------------PPHHQ--GMIFSKGPHMGMQMPPTGPNMSPYQTH- 105
             .||.|..|...|.                |.::|  ||......|.||..||     ||...| 
 Frog    54 -QGPAGYPPENMHQMHKPMDSIHDKAIPEDPRYNQMKGMSMRPAAHSGMGPPP-----SPMDQHS 112

  Fly   106 -GMPP---NAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMR 166
             |.|.   |:...|..|...|||.|||.|...|..|:.              ..||:       :
 Frog   113 QGYPSPLGNSEHVPSPVPSNGPPSGPPMPSGPSAVNME--------------NSDPQ-------Q 156

  Fly   167 ATSKH-QHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPG-----PPIGPPGAP 225
            .||:. ...|.||::.||.||.||::|||.:.:...:|.|:|.  ::|.||     |.:.||.|.
 Frog   157 QTSRSPTPFNQNQLHQLRAQIMAYKMLARGQALPDHLQMAVQG--KRPMPGMQQQMPTLPPPAAS 219

  Fly   226 G---GPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQ 287
            |   ||.||       |||| ...:|...||     .|.|...|.|.| ||.....|..||    
 Frog   220 GTGAGPAPG-------PVPP-NYNRPHGMAG-----PTMPPPGPSGAP-PGMPGHPAGAPP---- 266

  Fly   288 GQPLPPQPPQVGGPPPIQQQQ--PPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSS 350
             :|.|..|......|....|:  |||...:.|..||..|                       |::
 Frog   267 -KPWPEGPMANAAAPATAPQKLIPPQPTGRPSPAPPAVP-----------------------PAA 307

  Fly   351 PMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRI 415
            .         |.|||.:|.|    |...|.||.....|||||||.:.||.||||:.:|||||.|:
 Frog   308 S---------PVMPPQTQSP----GQPAQPPPIVQFHPKPNRITPIQKPRGLDPVEVLQEREYRL 359

  Fly   416 AARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLY 480
            .|||:.|:|||:.||.::..|||.:|.|||:|||:||||||||.|.|.|.||||.||||||.|.|
 Frog   360 QARIAHRIQELENLPGSLPGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAY 424

  Fly   481 KRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAV 545
            ||:|||.|||||.|||||||||:|.||||||||.|:|.::|||.||.:||||:...::.::.|||
 Frog   425 KRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEFHRSVTGKIQKLTKAV 489

  Fly   546 MNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVK 610
            ..:|||.|||||||.||||||||||||||||||||||||||||||||:||.|||||::|||::|:
 Frog   490 ATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVR 554

  Fly   611 QHKDDQ-MKKKEEEGKRLIQFKKE-----LLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDD 669
            |||..| :|:|:...|:.:|...|     |...||  .:||.|.::|:.:.|:...:||.|||.|
 Frog   555 QHKAVQALKEKKRRKKKKVQEITEGQQSALGPDGE--PLDETSQMSDLPIKVIHVESGKILTGAD 617

  Fly   670 APMLKHLHRWLNMHPGWDWI--DDEEDSCGSNDDHKPKVEEQPTATE----DATDKAQATGNDE- 727
            ||....|..||.|:||::..  .|.|:|...:::.:...::||:.|.    |.|.|.....:|: 
 Frog   618 APKAGQLEAWLEMNPGYEVAPRSDTEESESEDEEEEEDEQQQPSVTSLLAVDETKKIADPDSDDV 682

  Fly   728 ---DAKDLITKAKVE-DDEYRTEE------QTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLE 782
               .|:::|..|:.: ||||....      |:||::||.:.|||.:|::::|||.||:|||||||
 Frog   683 SEVHAREIIDNARQDVDDEYGISHAETSGLQSYYAVAHAVSEKVDKQSTLLVNGILKQYQIKGLE 747

  Fly   783 WLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPA 847
            |||||||||||||||||||||||||||:|:||||:.|::.||:|||||||||.|||.||:||.|:
 Frog   748 WLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDKWGPS 812

  Fly   848 VGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKL 912
            |..|||||||..||.....:|:.|||||||||||:||||.:||||:|||||:|||||||||||||
 Frog   813 VVKVSYKGSPAARRAFVPMLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKL 877

  Fly   913 TQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNE 977
            ||||||||:||.|:|||||||||||||||||||||||:|||||||||||||||||.|||||:|||
 Frog   878 TQVLNTHYVAPRRVLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNE 942

  Fly   978 EETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSE 1042
            |||||||||||||||||||||||||||.|||:||||:||||||:||||||:|||:||||||||||
 Frog   943 EETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSSLQRVLYRHMQAKGVLLTDGSE 1007

  Fly  1043 KGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVVSGPDLYRVSGKFELLDRI 1106
            |.|.||||.|.|||||:||||:||||:|||||||.:.:|.| ..|:|.|.||||.||||||||||
 Frog  1008 KDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFSGGIVQGADLYRASGKFELLDRI 1072

  Fly  1107 LPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFL 1171
            ||||:||.|:||||||||..|||:|||..:|.|.||||||||||||||.||:.||...|:.|:||
 Frog  1073 LPKLRATQHKVLLFCQMTTLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNESSSEYFIFL 1137

  Fly  1172 LSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAA 1236
            |||||||||||||:||||:|||||||||||||||||||||||:||||||||.|||||||:|||||
 Frog  1138 LSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAA 1202

  Fly  1237 RYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEI 1301
            :||||:|:||||||||||||:..||:.|||.||..:: ::|||:||||||.:|.||||.|||.::
 Frog  1203 KYKLNVDQKVIQAGMFDQKSSSHERKVFLQAILEHEE-QDEEEDEVPDDETVNQMIARHEEEFDL 1266

  Fly  1302 FKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYT 1366
            |.|||.:|::|:......:.||::|.|||.|:.|||.||||...:.:|:.:.|||||.||||||:
 Frog  1267 FMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRNRKEVDYS 1331

  Fly  1367 DSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRK-------------NRKEESDDDSLILKRRR 1418
            ||||||:|||||::|. .:|.|||...|:..||||             .|..|.||:....|:|.
 Frog  1332 DSLTEKQWLKAIEEGT-LEEIEEEVRQKKTTRKRKRDIDPCIVMPTTSTRGRERDDEGKKQKKRG 1395

  Fly  1419 RQNLDKRS------KKQMHKIMSAVIKHNQ--DGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKK 1475
            |...:|.|      .|:|.||:.||||:..  :||.|||.|::||||:.||:|||:|::|||.:|
 Frog  1396 RPPAEKLSPNPPKLTKKMKKIVDAVIKYKDSGNGRQLSEVFIQLPSRKELPEYYELIRKPVDFRK 1460

  Fly  1476 ILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVA 1540
            |.:||.:.||..||:||||.|.||||||.:|.|.||||.|||.||.||...||:|          
 Frog  1461 IKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKI---------- 1515

  Fly  1541 AGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSN 1605
              :...|:.|     ....:::|..::||:.|      :.:||:|:||.:.              
 Frog  1516 --EKEEESEG-----EESEEEEDVEEEGSESE------SRSVKVKIKLGRK-------------- 1553

  Fly  1606 VSSGAATTSKKQTRRKRSQK-------KYTISDDDDDD 1636
                    .|.|.|.|..::       |..|||||.::
 Frog  1554 --------EKGQERMKGRRRTGRGCRAKPVISDDDSEE 1583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 172..202 CDD:214931 12/29 (41%)
Drf_FH1 251..390 CDD:283903 36/140 (26%)
HSA 501..573 CDD:214727 46/71 (65%)
BRK 649..693 CDD:197800 17/45 (38%)
PHA02934 687..>824 CDD:165245 71/153 (46%)
SNF2_N 776..1071 CDD:278600 245/294 (83%)
DEXDc 793..932 CDD:238005 105/138 (76%)
Helicase_C 1097..1212 CDD:278689 92/114 (81%)
SnAC 1304..1375 CDD:291293 37/70 (53%)
Bromo_SNF2L2 1425..1530 CDD:99947 62/112 (55%)
smarca4NP_001362194.1 QLQ 164..198 CDD:370169 14/33 (42%)
SMC_prok_A 341..>560 CDD:274009 152/218 (70%)
HSA 446..516 CDD:369406 44/69 (64%)
BRK 597..639 CDD:197800 16/41 (39%)
DEXHc_SMARCA4 715..965 CDD:350820 200/249 (80%)
PLN03142 734..>1216 CDD:215601 390/481 (81%)
SnAC 1275..1340 CDD:373166 33/64 (52%)
Bromo_SNF2L2 1408..1515 CDD:99947 61/106 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 498 1.000 Domainoid score I356
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1572 1.000 Inparanoid score I88
OMA 1 1.010 - - QHG52479
OrthoDB 1 1.010 - - D41262at33208
OrthoFinder 1 1.000 - - FOG0001147
OrthoInspector 1 1.000 - - otm49003
Panther 1 1.100 - - LDO PTHR10799
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X702
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1111.080

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