DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and Mi-2

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster

Alignment Length:	1243	Identity:	365/1243 - (29%)
Similarity:	570/1243 - (45%)	Gaps:	263/1243 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 HHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQH 612
            ||....|..:::.:..|..:....:.|.:..|::                           :::|
  Fly   547 HHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKR---------------------------IQRH 584

  Fly   613 KDDQMKKKEEEGKRLIQFKKELLMSG---EYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLK 674
            ||....|..::.:.|   ::....:|   |::              :|::....:...|.:.|
  Fly   585 KDKVGMKANDDAEVL---EERFYKNGVKPEWL--------------IVQRVINHRTARDGSTM-- 630

  Fly   675 HLHRWLNM-HPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKV 738
            :|.:|..: :....|.::.:|..|.    :..::.........|.:...:.:.:..|...:|.||
  Fly   631 YLVKWRELPYDKSTWEEEGDDIQGL----RQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKV 691

  Fly   739 EDDEYR--------TEEQTYYSIAHTIHEKVVEQASIMVNGT---LKEYQIKGLEWLVSLYNNNL 792
            ||||.|        .|:.|      |..:|..|.....:.||   |..|||:|:.||...:...:
  Fly   692 EDDEDRPVKHYTPPPEKPT------TDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGI 750

  Fly   793 NGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSP 857
            :.||||||||||||||::.:..|.......||:|:.||||||.||..|||.|||....::|.|..
  Fly   751 DTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDK 815

  Fly   858 QGRRLLQ----------------NQMRAT--KFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHR 904
            ..|.:::                :::|.|  |||||||:||.:..|.|.|..|.|..:::||.||
  Fly   816 DSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHR 880

  Fly   905 MKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATT 969
            :|::..|..::||::.|| |:||||||||||.|.||:.|||||....|.....|:
  Fly   881 LKSNQSKFFRILNSYTIA-YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ---------- 934

  Fly   970 GEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKG 1034
            ||..::::||.   ::|||::|.|.:|||||.:|...:|.|.|:|::.::||:|:..||
  Fly   935 GEFADVSKEEQ---VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------ 990

  Fly  1035 VLLTDGSE--KGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVS 1097
            .:||...|  ..|.| ||:.:|:|.::.|:|.||||::|....|:.....||...::  .|.:.:
  Fly   991 FILTKNYEALNSKSG-GGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEIN--SLTKAA 1052

  Fly  1098 GKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNA 1162
            ||..||.::|.:|||.|||||:|.|||:.:.|:||:|...|:.|.|:||......|.|.:.:|||
  Fly  1053 GKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNA 1117

  Fly  1163 KGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNS 1227
            .|:..|||||||||||||:||.|||||:|:|||||||.|:||..|||||||.|:|.:.|.:|.||
  Fly  1118 PGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNS 1182

  Fly  1228 VEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQF-------LQTILHQDDNEEEEENEVPDD 1285
            ||||:...|:.|:.:...|::.|| ..|.....:|:.       .:.:..:||.||....   ||
  Fly  1183 VEERVTQVAKRKMMLTHLVVRPGM-GGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHY---DD 1243

  Fly  1286 EMINMMIARSEEEIE-----------IFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDE 1339
            :.:..::.|:...||           .||......|:|:||         :|:|    :.|.|.|
  Fly  1244 KAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEE---------EETE----IIKQDAE 1295

  Fly  1340 ---------VERFHY-QYDEDT--ILGRGSRQRKEVDYTD--------SLTEKEWLKAIDDGAEF 1384
                     :.|.|| |:.||.  .||:|.|.||:|:|||        :..:..|.   |:|:|:
  Fly  1296 NSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQ---DNGSEY 1357

  Fly  1385 DEE-----------EEEDDSKRKRRKRKNRKEESDDDSL--ILKR------------RRR----- 1419
            :.|           ::.||.....||.|.|.|..||..|  :|.|            |:|
  Fly  1358 NSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLN 1422

  Fly  1420 -------------------QNLDKRSKKQMHKIMSAVIKH-NQDGRTLSEPFMKLPSRQRLPDYY 1464
                               ::|..:|::.....:|..::| .:.|...:|.|.....|:.|...:
  Fly  1423 AIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQH 1487

  Fly  1465 EIIKRPVD--IKKILQRIEDCK-YADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGA 1526
            .:.:..|.  |:|.:|..|... |..:.||   .::.|:..:      |.:..|..||:....|.
  Fly  1488 VLTRIGVMSLIRKKVQEFEHINGYYSMPEL---ILKPCEPVR------SALKQDVAALEAPPTGG 1543

  Fly  1527 ---RQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGS-DDEEIATTSAAAVKMK-- 1585
               :...|:.:...|.:|..:...|...|  ::.|.|.:...|..| :..|:.....|....|
  Fly  1544 NVDKSATTSNSVTPATSAAPSPAPASEKG--EDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPG 1606

  Fly  1586 -LKLNKSLASAPATPTQSSSNVSSGAATTSKKQ------------TRRKRSQK--------KYTI 1629
             :|....:..|......|.:.|.:..|.|..|:            |..|..:|        ..|:
  Fly  1607 DVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTV 1671

  Fly  1630 SDDDDDDM 1637
            .||||||:
  Fly  1672 IDDDDDDV 1679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	4/24 (17%)
		BRK	649..693	CDD:197800	6/44 (14%)
		PHA02934	687..>824	CDD:165245	42/147 (29%)
		SNF2_N	776..1071	CDD:278600	127/314 (40%)
		DEXDc	793..932	CDD:238005	67/156 (43%)
		Helicase_C	1097..1212	CDD:278689	67/114 (59%)
		SnAC	1304..1375	CDD:291293	25/90 (28%)
		Bromo_SNF2L2	1425..1530	CDD:99947	22/111 (20%)
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CHROMO	490..558	CDD:237991	3/10 (30%)
		CHROMO	615..667	CDD:214605	8/57 (14%)
		SNF2_N	734..1028	CDD:278600	127/314 (40%)
		DEXDc	751..907	CDD:238005	67/156 (43%)
		Helicase_C	1053..1167	CDD:278689	67/113 (59%)
		DUF1087	<1292..1337	CDD:283996	18/44 (41%)
		DUF1086	1380..1517	CDD:283992	27/136 (20%)
		CHDCT2	1756..1927	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467181
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840