Protein Alignment brm and Chd3

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 271/812 - (33%)
• Similarity: 421/812 - (51%)
• Gaps: 138/812 - (16%)

  Fly   633 ELLMSGEYIGIDEGSIVAD-MRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWID-----D 691
            |.:..|:.: :...|:||. .|...:|:.:.::|...|..:.:..:|: .:.|.|..:.     .
  Fly   126 EWIPEGQML-LHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRY-GIKPEWLLVQRVINHS 188

  Fly   692 EEDSCGS-----------ND-------DHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKV 738
            ||.:.|:           ||       |..|.:.:.....:......:....|..|..:....|.
  Fly   189 EEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKY 253

  Fly   739 EDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLG 803
            ||...                 .:::|.:    .|..:||:|:.||...:...:..|||||||||
  Fly   254 EDQPV-----------------FLKEAGL----KLHPFQIEGVSWLRYSWGQGIPTILADEMGLG 297

  Fly   804 KTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLL----- 863
            |||||:..:..|.......||:||.||||||.||..|.|.|||.:..|:|.|....|.::
  Fly   298 KTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEI 362

  Fly   864 -----------QNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLN 917
                       :||.: .||||:||:||::..|.|.|..|.|..:::||.||::::..|..::|:
  Fly   363 SFEEVTTKTMRENQTQ-YKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILS 426

  Fly   918 THYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETIL 982
            .:.|. |:||||||||||.|.||:.|||||....|....||:          .|..::::||.
  Fly   427 KYRIG-YKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQ----------AEFTDVSKEEQ-- 478

  Fly   983 IIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHG 1047
             ::|||::|.|.:|||||.:|...:|.|.|:|::.::|::|:..|||:.:|..       |..:.
  Fly   479 -VKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNF-------KALNQ 535

  Fly  1048 KGGAK--ALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLY------RVSGKFELLD 1104
            |||.:  :|:|.::.|||.||||::|....|:        ..:|...||      :.|||.:||.
  Fly   536 KGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEE--------ATISPSGLYEMSSLTKASGKLDLLS 592

  Fly  1105 RILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFV 1169
            ::|.:|||.|||||||.|||:.:.::|.:|....:.|.|:||:.|.:.|.:.:.:||...|:.||
  Fly   593 KMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFV 657

  Fly  1170 FLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILA 1234
            |||||||||||:||.|||||:|||||||||.|:||..||||:||:.:|.:.|.:|.|||||||:.
  Fly   658 FLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQ 722

  Fly  1235 AARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILH--QDDNEEEEENEV--PDDEMINMMIARS 1295
            .|::|:.:...|::.||....:..|:.:  |:.||.  .:|..::.::|.  .||:.:..::.|:
  Fly   723 VAKHKMMLTHLVVRPGMGGMTTNFSKDE--LEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRT 785

  Fly  1296 EEEIE-----------IFKRMDAERKKEDEEIHPGR------------ERLIDESE--LPDWLTK 1335
            ...||           .|| :.:...|||.|.|...            |.|:.:|:  ||....|
  Fly   786 NRGIEEKESWANEYLSSFK-VASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKK 849

  Fly  1336 DDDEVERFHYQYDEDTILGRGSRQRKEVDYTD 1367
            ...:     .|.|.::|:|:|.|.|||:||::
  Fly   850 QSQQ-----SQVDVESIMGKGKRIRKEIDYSN 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	4/17 (24%)
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196	8/46 (17%)
		PLN03142	739..>1368	CDD:215601	249/682 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	5/20 (25%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	9/53 (17%)
		PLN03142	266..>768	CDD:215601	216/533 (41%)