Protein Alignment brm and chd1l

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_956607.1
• Gene: chd1l / 393283
• ZFINID: ZDB-GENE-040426-892
• Length: 1026
• Species: Danio rerio
• Alignment Length: 896
• Identity: 277/896 - (30%)
• Similarity: 430/896 - (47%)
• Gaps: 138/896 - (15%)

  Fly   773 LKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNW 837
            |:.||:.|::||.....|....||.||||||||.|||||:.|.....|:.||:|::.||:.|.||
Zfish    35 LRPYQLDGVKWLSLCMKNQQGCILGDEMGLGKTCQTISLLAYARGSLKMNGPFLVLCPLAVLENW 99

  Fly   838 VLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRA-TKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDE 901
            ..|.|::.|::.|:.|.|..:.|..||..::: .:|:|||||||..:||...|...:||.:::||
Zfish   100 RQELERFCPSLSVICYTGDKEKRAELQQNLKSDPRFHVLLTTYEMCLKDARYLKSWKWKILVVDE 164

  Fly   902 GHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPF 966
            .||:||....|.|.|. .:...:|:||||||:||.|.|:::||.|:.||:|.. ...|.:.||
Zfish   165 AHRLKNQESLLHQTLK-EFTVGFRVLLTGTPIQNNLQEVYSLLTFIQPSVFLP-EAVEDFVNA-- 225

  Fly   967 ATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKH-- 1029
                 ..::..|..  ::..||:||:||||||:|.||..:||.|.|.::...:||||:..||.
Zfish   226 -----YADIQTEPA--LVDELHQVLQPFLLRRVKAEVAAELPKKTELVVFHGLSALQKRYYKAIL 283

  Fly  1030 MQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLY 1094
            |:......||.|.|.:        |:|.::||||..:||::|..:|.:..:        .|..|.
Zfish   284 MRDLDAFRTDQSTKTR--------LLNVLMQLRKCVDHPYLFDGVEPEPFE--------MGEHLV 332

  Fly  1095 RVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRK 1159
            ..|||..|||.:|..|:...|.||||.|||:.:.|::|||.:|.:.|.||||:.:.|:|...::.
Zfish   333 EASGKLSLLDSMLAYLQEGGHHVLLFSQMTRMLDILQDYLEYRGYSYERLDGSVRGEERNLAIKN 397

  Fly  1160 FNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMT 1224
            |:.|  |||:|||||:|||:|:||..||||:..|.|:||..||||..|||||||...|:|:||:.
Zfish   398 FSTK--DVFIFLLSTKAGGVGMNLTAADTVIFVDGDFNPQNDLQAAARAHRIGQTRPVKVIRLLG 460

  Fly  1225 VNSVEERILAAARYKLNMDEKVIQAGMF---DQKSTGSERQQFLQTILH--QDDNEEEEENEVPD 1284
            .:::||.|.:.|..||.:.:.||:.|.|   ||..:.:...| |..||.  .|.....||:.|.|
Zfish   461 RDTIEEIIYSRAVSKLRLTDTVIEEGRFSLLDQAQSAASGLQ-LSEILKFGVDKLLSSEESSVQD 524

  Fly  1285 DEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDE 1349
            .: :.:::.:|.:...:.....|:..:.:||                   :|:|...:.|..|.|
Zfish   525 VD-LQLILGQSRDGQWLTDEEHAKLNESNEE-------------------EDEDMEGQNHMYYFE 569

  Fly  1350 DTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLIL 1414
            .....:......|..: :.|.||::             .|.:|::::.|..:|:...|....||.
Zfish   570 GKDYSKDPSAEDEKTF-ELLLEKQF-------------AEMEDAEKEGRALRNKAGVSLSGPLIN 620

  Fly  1415 KRRRRQNL------DKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDI 1473
            ..|:::.|      ::|.|:|     :|..|                 |.:|.:..:..:..::.
Zfish   621 PARKKRPLTEAELEERRQKRQ-----AAAAK-----------------RAKLQEERKKQQEELNY 663

  Fly  1474 KKILQRIEDCKYADL---------NELEKDFMQLCQNAQIYNEEASLIYLDS--IALQKVFVGAR 1527
            ||.:...:.|.|..|         .::|.|          .::..|....||  .|::.|.....
Zfish   664 KKKMAWWDSCGYRSLCLPRVDSEGEDMEPD----------EDDHVSFSSTDSDHTAIRYVLGDVT 718

  Fly  1528 QRITAAADAAAVAAGDNTGEAHGNGG--------SDNSDNDDDDGGDDGSDDEEIATTSAAAV-- 1582
            .......||..|...|::|. .|.||        ||......:..||  ..|.|:.......|
Zfish   719 HPQADREDAIIVHCVDDSGH-WGRGGLFTALGLRSDEPRKQYELAGD--MKDLELGNVLLFPVDD 780

  Fly  1583 KMKLKLNKSLASAPATPTQSSSNVSSGAATTS----KKQTRRKRSQKKYTI 1629
            |......:...:......:..:|..||...|:    .|:..:...|||.::
Zfish   781 KQSRLCGRDYLALIVAQQRDKANKLSGIRLTALDEGLKKIYKAAKQKKASV 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	222/602 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	19/115 (17%)
chd1l	NP_956607.1	PLN03142	35..>547	CDD:215601	213/542 (39%)
		DEAH box	163..166		2/2 (100%)
		Regulatory linker segment (RLS). /evidence=ECO:0000250|UniProtKB:Q86WJ1	594..628		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..655		13/70 (19%)
		Required for ATPase activity. /evidence=ECO:0000250|UniProtKB:Q86WJ1	608..666		14/79 (18%)
		Macro_Poa1p-like_SNF2	709..859	CDD:394880	26/126 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	877..929
		BRCT	931..1016	CDD:469589