Protein Alignment brm and CG4049

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Alignment Length: 1769
• Identity: 366/1769 - (20%)
• Similarity: 560/1769 - (31%)
• Gaps: 652/1769 - (36%)

  Fly   229 PPGSQHAGQPPVPPQQQQQPP----------PSAGTPP-------QCSTPPASNPYGPPVPGQKM 276
            |..:.....|.....|:.|.|          ||...|.       ..||.|...|...|....:.
  Fly     4 PEANMEESNPNYDVNQRLQKPEGWPHVNEFHPSMMYPDDPRRYFHNASTDPQHQPQQHPQQQPEQ 68

  Fly   277 QVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPP-EPHQHQLPNGGKPLSMGP 340
            .....|.|....|..|.|.|         ||||.|..|||:|.||. :|.||
  Fly    69 HPEQHPQHPLHSQQQPQQHP---------QQQPQQHPQQQTQQPPQLQPQQH------------- 111

  Fly   341 SGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPI 405
                                               ||.|:.|   |:|.|
  Fly   112 -----------------------------------PQAQIQP---PIPVP--------------- 123

  Fly   406 TLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTT 470
                         ||..|:....:|..|.|... :.:..:...||:|                ..
  Fly   124 -------------ISTPMEGTMEVPVKMPEYCP-ETSQPVEPDRVIN----------------PL 158

  Fly   471 LETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNK 535
            .|.|.|...|...::....|.:|.   .|:..:.|..:::..||.         |::|:....|.
  Fly   159 AEVAKNTVPYGHKRKNSAGEDQAA---NKKLSMAAAEEKKNSHLR---------KNIRDVMNENN 211

  Fly   536 AQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDE 600
            .....:         .|:||        |.||:.| :|..::..|::..|...|:: |.:.|.||
  Fly   212 LDTTTL---------AAQRE--------ESERLAR-VAGQQKSMREIQKQVVHKQI-FRILQLDE 257

  Fly   601 -------YISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVE 658
                   .::|   .|:.|..             :.|.:|.:.|..:                 :
  Fly   258 SEGIESCAVAN---PVEHHPP-------------VDFPEEEIASDTF-----------------D 289

  Fly   659 QCTGKKLTG---DDAPMLKHLHRWLNMHPG-WDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDK 719
            ......|:|   :|.     ||:..::.|. ...|||..|    :|......||:....||..:.
  Fly   290 DSNSSSLSGGSIEDV-----LHKGASVQPSEVVTIDDSSD----DDCILLSEEEEEEDDEDLNES 345

  Fly   720 AQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWL 784
            ..||.:....||:.   .|.|:    ..|...::||...|:.:..|. .:...:|.:||.|:.:
  Fly   346 DDATNSGMHVKDIY---NVPDE----NGQVVVNMAHPEGEETLYLAP-QIAKVIKPHQIGGVRF- 401

  Fly   785 VSLYNNNLNG------------ILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNW 837
              ||:|.:..            |||..||||||:|.:|.....: |.......|.::|::||.||
  Fly   402 --LYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFL-RHTSAKTVLCVMPINTLQNW 463

  Fly   838 VLEFEKWAP---------------------------------------AVGVVSY---------- 853
            :.||..|.|                                       .|.::.|
  Fly   464 LSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKL 528

  Fly   854 ------KGS---PQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHH 909
                  |||   |.|        ..:..:::...||.::|....|       :|.|||||:||.|
  Fly   529 VKTRKRKGSVIRPDG--------MDSSSDLMNLVYEALVKPGPDL-------VICDEGHRIKNSH 578

  Fly   910 CKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVE 974
            ..::..|. ......|::|||.||||.|.|.|.:::|:.|:...:.:.|...|..|. ..|:.|:
  Fly   579 AGISLALK-EIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPI-QNGQCVD 641

  Fly   975 LNEEETILIIRR---LHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQR------------ 1024
            ...::..|:..|   ||.:|..|:.||....::..||.|.||:|...|:|.||
  Fly   642 STPDDIKLMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVR 706

  Fly  1025 ----------------------VLYKHMQ--------------SKG-------------VLLTDG 1040
                                  |||..::              :||             :.|...
  Fly   707 TKAFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTKGAATPIVEPSADSSLSLASP 771

  Fly  1041 SEKGKHGKGG--------AKALMNTIV-------------------------------------- 1059
            .||..:|.|.        :||...|:.
  Fly   772 LEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEGKN 836

  Fly  1060 ------------------------------------------------------------QLRKL 1064
                                                                        ||...
  Fly   837 NYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNG 901

  Fly  1065 CN---------------------HPF-----MFQHIEEKYCDHTGG--HGVVSGPDLYRVSGKFE 1101
            ||                     .||     ..|..||..|.....  ...|||  |...|.|.|
  Fly   902 CNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSG--LISNSPKME 964

  Fly  1102 LLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLG----------W-RQFGYLRLDGTTKAEDRGE 1155
            :...||.:......|:|||.|....:.::|.||.          | :...|.||||:|.:::|..
  Fly   965 IFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERER 1029

  Fly  1156 LLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVL 1220
            |:.:||| .|:|.:||:|||||.||:||..|:.|:|||:.|||..|.||..|.:|.||.....|.
  Fly  1030 LVNEFNA-NSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVY 1093

  Fly  1221 RLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQ----TILHQD-DNEEEEEN 1280
            |::....:|::|         .|.::.:.||.|:.......:..|.    |.|.|| |::|:...
  Fly  1094 RIVMDRCLEKKI---------YDRQIKKQGMSDRIVDECNPEAHLSMKDITNLCQDYDSDEDTVE 1149

  Fly  1281 EV------------PDDE-----MINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESE 1328
            ||            |.:|     ..||....|.      |..:...|..|::..|....  ..|.
  Fly  1150 EVNKSTGDLSKPGSPSEEGSKPGSANMSPNASN------KSNNGPTKPLDDQNTPKSPN--GASH 1206

  Fly  1329 LPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDS 1393
            .|....|:|.:....|.....:|||          |.......||         .|..|....|.
  Fly  1207 SPIKTEKNDGQEHAVHVDGIINTIL----------DMHRHCVTKE---------PFMHESLLVDQ 1252

  Fly  1394 KRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMK----- 1453
            |.::..:..:::......|..|....|.......|..:||:      |.||..:::|..:
  Fly  1253 KDRKLSQAEKRQAHRSYELEKKAAVNQRFTYAPAKMNYKIV------NNDGTVITKPMNQQIKTN 1311

  Fly  1454 ------------LPSR--QRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQI 1504
                        :|:.  ||.....:.:..|:|:           ....|..:|
  Fly  1312 TSSSTGGRSTRWIPADVWQRQGMTAQEMTLPLDV-----------VIPTNSADK----------- 1354

  Fly  1505 YNEEASLIYLDSIALQKVFV-GARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDD-----DD 1563
                |::|..   |.|:|.| .:.:.|....|:..:.|...|.:..    .:.::.||     ||
  Fly  1355 ----ANIILK---AGQRVMVLKSAKGIYMQLDSGKIIAIRTTAKTE----PEKTNKDDVIDITDD 1408

  Fly  1564 GGDD----GSDDEEIATTSA----AAVKMKLKLNKSLASAPATPT---QSSSNVSSGAATTSKKQ 1617
            |..|    .|.:|::...:|    ..||.| :.|.:..|.|..|.   :|:.||....:.|....
  Fly  1409 GDTDTTKPQSPEEDVKDLTADDEPRVVKNK-ESNPATTSRPEMPAKDRKSTENVQHFKSQTQPNT 1472

  Fly  1618 TRRKRSQKKYTISD 1631
            |....:.:....||
  Fly  1473 TLATTTNQHQLPSD 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	37/171 (22%)
		PTZ00121	<477..651	CDD:173412	31/180 (17%)
		HSA	501..573	CDD:214727	13/71 (18%)
		BRK	650..691	CDD:462196	7/44 (16%)
		PLN03142	739..>1368	CDD:215601	207/929 (22%)
		Bromo_SNF2L2	1425..1530	CDD:99947	20/124 (16%)
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	69/282 (24%)
		HepA	<392..1121	CDD:440319	174/761 (23%)