DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and Smarca2

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001004446.1	Gene:	Smarca2 / 361745	RGDID:	1302988	Length:	1597	Species:	Rattus norvegicus

Alignment Length:	1722	Identity:	887/1722 - (51%)
Similarity:	1104/1722 - (64%)	Gaps:	231/1722 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYGHPMQHG 62
            |.|.|..||.|.| :|.|:..||..|.|||.|  .|...||..|||...||    |:...|.
  Rat     9 AMPHPGPSPGPGP-SPGPILGPSPGPGPSPGS--VHSMMGPSPGPPSVSHPMSTMGSADFPQ--- 67

  Fly    63 PPGQGPPGHHMPP---HHQGMIFSKGPHMGMQM--------PPTGPNMSPYQTHGMPPNAPTQPC 116
               :|....|.|.   |.:|::  :|.|.|...        |..||..||...|.....:| .|
  Rat    68 ---EGLHQLHKPMDGIHDKGIV--EGVHCGSMKGTSMRPPHPGVGPPQSPMDQHSQGYMSP-HP- 125

  Fly   117 IVSPGGPP---------GGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQ 172
              ||.|.|         |||.||:....:....:...:.:|.:......| :|.:
  Rat   126 --SPLGAPEHVSSPISGGGPTPPQMPPSQPGTLIPGDLQAMNQPDRGPSP-FSPV---------- 177

  Fly   173 HLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQ 237
                 |::.||.||.||::|||.:|:...:|.|:|..:..                 ||.|...|
  Rat   178 -----QLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTL-----------------PGIQQQQQ 220

  Fly   238 PPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPP 302
                 |||||                          |:.|        ||.||..||.||
  Rat   221 -----QQQQQ--------------------------QQQQ--------QQQQPQQPQQPQ----- 241

  Fly   303 PIQQQQPPQQQQQQSQPP-------PPEPHQHQL---PNGGKPLSMGPSGGQPLIPSSPMQPQVR 357
            ...|.||.||||||.|||       |..|.|..|   .|..:.||.....|:|    ||..|...
  Rat   242 QQTQAQPQQQQQQQQQPPTLVSYNRPSGPGQELLMTAQNTQRKLSAPAPSGRP----SPAPPAAT 302

  Fly   358 GTLPGMPPGSQVPQPGGGPQRQVPPAGMPMP------KPNRITTVAKPVGLDPITLLQERENRIA 416
                 .|..:.||    ||..|.|..|.|.|      |.:||:.:.||.||||:.:|||||.|:.
  Rat   303 -----QPTATAVP----GPSVQEPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQ 358

  Fly   417 ARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYK 481
            |||:.|:|||:.||.::..|||.:|.:||:|||:||||||||.|.|.|.|||||||||||.|.||
  Rat   359 ARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYK 423

  Fly   482 RTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVM 546
            |:|||.|||||.|||||||||:|.||||||||.|:|.::|||.||.:|:||:...::.:::|||.
  Rat   424 RSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVA 488

  Fly   547 NHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQ 611
            ..|||.|||||||.||||||||||||||||||||||||||||:|||:||.|||||::|||.:|.:
  Rat   489 TWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWE 553

  Fly   612 HKDDQMKKKEEEGKRLIQFKKELLMSGE-YIG-----IDEGSIVADMRVHVVEQCTGKKLTGDDA 670
            ||..|..|::::.:|..:..:|....|| .:|     |||.|.::|:.|.|....|||.|.|.:|
  Rat   554 HKQAQAAKEKKKRRRRRKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEA 618

  Fly   671 PMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGN-----DEDAK 730
            |....|..||.|:||:: :....||..|..|::.:.||:.::.::..:|.....|     ::||:
  Rat   619 PKASQLDAWLEMNPGYE-VAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSKEVSEKDAR 682

  Fly   731 DLITKAKVE-DDEYRTE-----EQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYN 789
            .:|..||.: ||||..:     .|:||::||.|.|:|.:|:::::|||||.||::||||:|||||
  Rat   683 QIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN 747

  Fly   790 NNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYK 854
            ||||||||||||.|||||||:|:||||:.|.:.||||||||||||.||..||:||||:...:|||
  Rat   748 NNLNGILADEMGPGKTIQTIALITYLMEHKGLNGPYLIIVPLSTLSNWTYEFDKWAPSAVKISYK 812

  Fly   855 GSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTH 919
            |:|..||.|..|:|:.|||.|||||||:||||.:||||:|||||:||||||||||||||||||||
  Rat   813 GTPAMRRSLVPQLRSGKFNALLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTH 877

  Fly   920 YIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILII 984
            |:||.|:|||||||||||||||||||||||:|||||||||||||||||.|||:|:||||||||||
  Rat   878 YVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILII 942

  Fly   985 RRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKG 1049
            ||||||||||||||||||||.|||:||||:|||||||||::||:|||:||:||||||||.|.|||
  Rat   943 RRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKG 1007

  Fly  1050 GAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVVSGPDLYRVSGKFELLDRILPKLKAT 1113
            |||.|||||:||||:||||:|||||||.:.:|.| .:||::|.:|||.||||||||||||||:||
  Rat  1008 GAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRAT 1072

  Fly  1114 NHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGG 1178
            |||||||||||..|||:|||..:|.|.|||||||||:|||..||:|||..||..|:|||||||||
  Rat  1073 NHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGG 1137

  Fly  1179 LGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMD 1243
            ||||||.||||||||||||||||||||||||||||:||||||||.|||||||:|||||:||||:|
  Rat  1138 LGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVD 1202

  Fly  1244 EKVIQAGMFDQKSTGSERQQFLQTIL-HQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDA 1307
            :||||||||||||:..||:.|||.|| |:::||||:  ||||||.:|.||||.|||.::|.|||.
  Rat  1203 QKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEED--EVPDDETLNQMIARREEEFDLFMRMDM 1265

  Fly  1308 ERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEK 1372
            :|::||......:.||::|.|||.|:.|||.||||...:.:|:.|.|||||||::|||:|:||||
  Rat  1266 DRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEK 1330

  Fly  1373 EWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRS------KKQMH 1431
            :||:||:||...:.|||....|||||:..::....:|.....|||.|...:|.|      .|||:
  Rat  1331 QWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMN 1395

  Fly  1432 KIMSAVIKH-------------------NQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKIL 1477
            .|:..||.:                   |..||.|||.|::||||:.||:|||:|::|||.|||.
  Rat  1396 AIIDTVINYKDRCNVEKVPCNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIK 1460

  Fly  1478 QRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAG 1542
            :||.:.||..|.:||||.|.||.|||.:|.|.|.||.|||.||.||..|||:|....:
  Rat  1461 ERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEE------- 1518

  Fly  1543 DNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVS 1607
                       |:...|::::     .:|||.:...|.:||:|:||||.               .
  Rat  1519 -----------SEEESNEEEE-----EEDEEESEAEAKSVKVKIKLNKK---------------E 1552

  Fly  1608 SGAATTSKKQTRRKRSQKKYTISD-DDDDDMD 1638
            .....|.|.:.|..|.:.|..:|| |.|::.|
  Rat  1553 EKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQD 1584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	11/29 (38%)
		Drf_FH1	251..390	CDD:283903	44/154 (29%)
		HSA	501..573	CDD:214727	45/71 (63%)
		BRK	649..693	CDD:197800	16/43 (37%)
		PHA02934	687..>824	CDD:165245	67/147 (46%)
		SNF2_N	776..1071	CDD:278600	238/294 (81%)
		DEXDc	793..932	CDD:238005	103/138 (75%)
		Helicase_C	1097..1212	CDD:278689	95/114 (83%)
		SnAC	1304..1375	CDD:291293	37/70 (53%)
		Bromo_SNF2L2	1425..1530	CDD:99947	60/129 (47%)
Smarca2	NP_001004446.1	QLQ	173..207	CDD:286024	15/49 (31%)
		HSA	443..515	CDD:214727	45/71 (63%)
		BRK	597..639	CDD:197800	16/42 (38%)
		SNF2_N	734..1029	CDD:278600	238/294 (81%)
		DEXDc	751..890	CDD:238005	103/138 (75%)
		Helicase_C	1056..1171	CDD:278689	95/114 (83%)
		SnAC	1266..1333	CDD:291293	34/66 (52%)
		Bromodomain	1340..>1426	CDD:295360	22/85 (26%)
		Bromo_SNF2L2	1389..1513	CDD:99947	59/123 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353996
Domainoid	1	1.000	502	1.000	Domainoid score	I327
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	1576	1.000	Inparanoid score	I80
OMA	1	1.010	-	-		QHG52479
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770