Protein Alignment brm and Ercc6l2

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_038952187.1
• Gene: Ercc6l2 / 361197
• RGDID: 1561537
• Length: 1561
• Species: Rattus norvegicus
• Alignment Length: 1067
• Identity: 256/1067 - (23%)
• Similarity: 422/1067 - (39%)
• Gaps: 272/1067 - (25%)

  Fly   726 DEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNN 790
            |:....|::..::.:|.        .||.:||            |..|::||.:|.::|...|..
  Rat    95 DQKIPSLVSAFQLSEDG--------DSIPYTI------------NRYLRDYQREGAQFLYRHYIK 139

  Fly   791 NLNGILADEMGLGKTIQTISLVTYLMDRK---------------KVMGP---------YLIIVPL 831
            ....||.|:||||||||.||.:..::.:|               |.|..         :||:.||
  Rat   140 GRGCILGDDMGLGKTIQVISFLAAVLHKKGTREDIENNMPEFLLKSMKKESSSTARKMFLIVAPL 204

  Fly   832 STLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKY 896
            |.|.||..|.:.|. ...|....||.:...|  .:::..|..:.|||||.:......|..::|..
  Rat   205 SVLYNWKDELDTWG-YFRVTVLHGSKKDNEL--TRLKQRKCEIALTTYETLRLCLEELNSLEWSA 266

  Fly   897 MIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQW 961
            :|:||.||::|.:.::|:|:.. .....|:.||||.|||.:.|||.::::.:|.:..|...|::.
  Rat   267 IIVDEAHRIRNPNARVTEVMKA-VKCKVRIGLTGTILQNNMKELWCVMDWAVPGLLGSRIHFKKQ 330

  Fly   962 FNAPF-------AT-----TGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYI 1014
            |:.|.       ||     ||.|.          :.||.|.:..:.|||.|..::.|||.|.:.:
  Rat   331 FSDPVEHGQRHTATKRELATGRKA----------MHRLAKKMSGYFLRRTKTLIKGQLPKKEDRM 385

  Fly  1015 IKCDMSALQRVLYK---HMQSKGVLLT--------DGSEKGK-------HGKGGAKALMNTIVQL 1061
            :...::..|:.:|:   ..:...::||        .|.::.|       .|.......::.:..|
  Rat   386 VYSSLTDFQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCCYKTNSQGDTVRTLCLSYLTVL 450

  Fly  1062 RKLCNHPFMFQ------HIE---EKYCDHT-------------GGHGVVSGPDLYRVSGKFELLD 1104
            :|:.||..:.|      |.|   ::.||..             .....:|.|   :.|||.::||
  Rat   451 QKVANHVALLQAASTSKHQETLIKRICDQVFSRFPDFVQKSKDAAFETLSDP---KYSGKMKVLD 512

  Fly  1105 RILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFV 1169
            ::|...:....:||||...|:.:.:::.|.......|.||||:||:|:|.:::::||: ..||.:
  Rat   513 QLLNHFRKHRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNS-SQDVNI 576

  Fly  1170 FLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILA 1234
            .|:||.|||||||...|:.|::||..|||..||||.|||:||||..:|:|.||:::.:|||.:..
  Rat   577 CLVSTMAGGLGLNFIGANVVILFDPTWNPANDLQAIDRAYRIGQCRDVKVFRLISLGTVEEIMYL 641

  Fly  1235 AARYKLNMDEKVIQA------------------------GMFDQKSTGS-ERQQFLQT------- 1267
            ...||..:...|:.:                        .:|..:|.|| ..:..|:|
  Rat   642 RQVYKQQLHCVVVGSENAKRYFEAVQGSKEHRGELFGVHNLFKLRSQGSCLTRDILETRSQPGEL 706

  Fly  1268 ----------------ILHQDDNEEE----------------EENEVPDD----EMINMMIARSE 1296
                            :||..:.:.|                ::.|.|.|    |..|:
  Rat   707 QIISLGFWDFVVKCFIVLHLREGQVEAGIMTATTWLKGEASAQKLETPRDPDCQEPTNV------ 765

  Fly  1297 EEIEIFKRMDAERKKEDEEIH--------PGRERLID----------ESELPDWLTKDDDEVERF 1343
              .|::..|..|........|        ||....:.          |::.......|.:.|...
  Rat   766 --CELYSDMSDEESVGKAVKHKVSGPSRTPGSSAQLTLLQCGFSKLFEAKCESVQDGDGNPVSSD 828

  Fly  1344 HYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESD 1408
            ....::...|...:||.......||:...|..|:  |..:..:|:...| |.::...:|...|||
  Rat   829 GSSDEQPMCLSAKARQAACQKTWDSVCTSEHQKS--DNIQTPDEKCVSD-KSEKTLEQNVSSESD 890

  Fly  1409 DDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDI 1473
            |::            |......|..|......::|...:   |......||:|      |.|:..
  Rat   891 DET------------KCHSTAGHHCMGQGDTESEDSDVI---FPTQDPTQRVP------KNPICC 934

  Fly  1474 KKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEAS-LIYLDSIALQKV--------------- 1522
            |.:|...||.:..|..::..|..:  ||:...|...| .:||:::.|:.|
  Rat   935 KLLLGESEDSETEDPVKVNHDDGR--QNSGRGNGPVSNFLYLENMTLKSVRKRKGTDDISDESDD 997

  Fly  1523 ---FVGAR---QRITAAADA------------AAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGS 1569
               |..:|   ||.||:...            :.:.|.|.......:|...:...:|....||.|
  Rat   998 IDMFPKSRIRKQRATASLKLKSKKENKRKHYNSPITAKDTNQVCEADGDCSSQVIEDFSSSDDSS 1062

  Fly  1570 DDEEIATTS----AAAVKMKLKLNKSL 1592
            ....::.|.    |..||.|..|...|
  Rat  1063 SVSHVSFTKLNHRAETVKGKSNLRNKL 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	197/790 (25%)
		Bromo_SNF2L2	1425..1530	CDD:99947	26/126 (21%)
Ercc6l2	XP_038952187.1	Tudor_SF	17..72	CDD:470623
		HepA	<47..649	CDD:440319	172/591 (29%)
		DEXHc_ERCC6L2	122..369	CDD:350763	77/260 (30%)
		VIGSSK	<1132..1155	CDD:464308