DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and smarca4a

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_853634.1	Gene:	smarca4a / 353295	ZFINID:	ZDB-GENE-030605-1	Length:	1627	Species:	Danio rerio

Alignment Length:	1762	Identity:	919/1762 - (52%)
Similarity:	1115/1762 - (63%)	Gaps:	275/1762 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASPSP--ANSPMPPPQ---APSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYG 56
            |::|.|  ..:|.|.|.   .|||.|....||.|||.|  .|...||..|||..|||    |..|
Zfish     1 MSTPDPPMGGTPRPGPSPGPGPSPGAMLGPSPGPSPGS--AHGMMGPSPGPPSSGHPLPPQGPSG 63

  Fly    57 HPM---------------------------------QHGPPGQGPPGHHMPPHHQGM-------- 80
            :|.                                 |.|..|.|||...|..|.||.
Zfish    64 YPQDNMHQMHKPMEGMHEKGIPEDQRYGQMKGMGMRQGGHSGMGPPPSPMDQHSQGYPSPLGGSD 128

  Fly    81 -----IFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQP-------CIVSP---GGPP------ 124
                 :.:.||..|..| |:||...|.:  |..|.|..|.       .:..|   ||||
Zfish   129 HAPSPVPANGPPSGPMM-PSGPGAMPME--GGDPQAMAQQNRSGGAGGVAGPGPSGGPPNAGGPG 190

  Fly   125 --GGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQIT 187
              |||.|                                            .|.||::.||.||.
Zfish   191 GAGGPTP--------------------------------------------FNQNQLHQLRAQIM 211

  Fly   188 AYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSA 252
            ||::|||.:|:...:|.|:|.  ::|.||.   ..|.|..||...|.||            ||..
Zfish   212 AYKMLARGQPLPDHLQMAVQG--KRPMPGM---QQGMPNMPPASGQGAG------------PPGP 259

  Fly   253 GTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQS 317
            |.|            ||..|....      ||...|..:||..|  .|.||..|.||      .:
Zfish   260 GVP------------GPGGPNYNR------PHGMVGPNMPPPGP--SGVPPGLQGQP------TN 298

  Fly   318 QPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRG----TLPGMPPGSQVPQPGGGPQR 378
            .||.|.| :..:.|...|    .|..|.|||     ||..|    ..|.:||.:....|   ||.
Zfish   299 GPPKPWP-EGPMVNAAAP----ASAPQKLIP-----PQPTGRPSPAPPSVPPAASPVMP---PQT 350

  Fly   379 QVP--PAGMPM---PKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLR 438
            |.|  ||..||   .|.||||.:.||.||||:.:|||||.|:.|||:.|:|||:.||.:::.|||
Zfish   351 QSPGQPAQPPMVLHQKQNRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLR 415

  Fly   439 LQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKL 503
            .:|.|||:|||:||||||||.|.|.|.||||.||||||.|.|||:|||.|||||.|||||||||:
Zfish   416 TKANIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKI 480

  Fly   504 EAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERM 568
            |.||||||||.|:|.::|||.||.:|:||:..|::.::.|||..:|||.|||||||.||||||||
Zfish   481 EQERKRRQKHQEYLNSILQHAKDFKEYHRSITAKMQKLTKAVATYHANTEREQKKENERIEKERM 545

  Fly   569 RRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQH------KDDQMKKKEEEGKRL 627
            ||||||||||||||||||||||||:||.|||||::|||::|:.|      ||.:.|||:::.:..
Zfish   546 RRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRAHKAAQALKDKKKKKKKKKPENA 610

  Fly   628 IQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWI--D 690
            ......|...||  .:||.|.::|:.|.|:...:||.|||.|||....|..||.|:||::..  .
Zfish   611 EGGAPALGPDGE--PLDETSQMSDLPVKVIHVDSGKILTGMDAPKAGQLDTWLEMNPGYEVAPRS 673

  Fly   691 DEEDSCGSNDDHKPKVEEQPT--ATED---ATDKAQATGNDEDAKDLITKAKVE-DDEYRTEE-- 747
            |.||| ||:::...:.|.||:  .||:   ..|......::.||:.:|..||.: ||||....
Zfish   674 DSEDS-GSDEEEDDEEEPQPSQAPTEEKKVIPDPDSEDVSEVDARHIIEHAKQDVDDEYGNSAFI 737

  Fly   748 ---QTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTI 809
               |:||::||.:.|||.:|:|::|||.||:||||||||||||||||||||||||||||||||||
Zfish   738 RGLQSYYAVAHAVTEKVEKQSSLLVNGQLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTI 802

  Fly   810 SLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNV 874
            :|:||||:.|::.||:|||||||||.|||.||:||||:|..|||||||..||.....:|:.||||
Zfish   803 ALITYLMEFKRLNGPFLIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFLPILRSGKFNV 867

  Fly   875 LLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPE 939
            |:|||||:||||.||||::|||||:|||||||||||||||||||||:||.|:|||||||||||||
Zfish   868 LVTTYEYIIKDKQVLAKLRWKYMIVDEGHRMKNHHCKLTQVLNTHYLAPRRVLLTGTPLQNKLPE 932

  Fly   940 LWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVE 1004
            ||||||||||:|||||||||||||||||.|||||:||||||||||||||||||||||||||||||
Zfish   933 LWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVE 997

  Fly  1005 HQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPF 1069
            .|||:||||:|||||||||||||:|||:|||||||||||.|.||||.|.|||||:||||:||||:
Zfish   998 AQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPY 1062

  Fly  1070 MFQHIEEKYCDHTG-GHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDY 1133
            |||||||.:.:|.| ..|:|.|.||||.||||||||||||||:||||:||||||||..|||:|||
Zfish  1063 MFQHIEESFSEHLGFTGGIVQGSDLYRASGKFELLDRILPKLRATNHKVLLFCQMTTLMTIMEDY 1127

  Fly  1134 LGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNP 1198
            ..:|.|.||||||||||||||.||:.||......|:|||||||||||||||:||||:||||||||
Zfish  1128 FAYRNFKYLRLDGTTKAEDRGMLLKNFNDPSHQYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNP 1192

  Fly  1199 HQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQ 1263
            |||||||||||||||:||||||||.|||||||:|||||:||||:|:||||||||||||:..||:.
Zfish  1193 HQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRA 1257

  Fly  1264 FLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESE 1328
            |||.||..:: ::|||:||||||.:|.||||||||.:.|.|||.:|::|:......|.||::|.|
Zfish  1258 FLQAILEHEE-QDEEEDEVPDDETVNQMIARSEEEFDHFMRMDLDRRREEARNPKRRPRLMEEDE 1321

  Fly  1329 LPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDS 1393
            ||.|:.|||.||||...:.:|:.:.||||||||||||:||||||:|||||::|. .||.|||...
Zfish  1322 LPTWIMKDDAEVERLTCEEEEEKMFGRGSRQRKEVDYSDSLTEKQWLKAIEEGT-LDEIEEEVRH 1385

  Fly  1394 KRKRRKRK----------------NRKEESDDDSLILKRRRRQNLDKRS------KKQMHKIMSA 1436
            |:..||||                .|..:.|||....|:|.|...:|.|      .|:|.|.:.|
Zfish  1386 KKTTRKRKRDRDLDLPGPATPSSSGRSRDKDDDGKKQKKRGRPPAEKLSPNPPSLTKKMKKTVDA 1450

  Fly  1437 VIKHNQ-DGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQ 1500
            |||:.. :||.|||.|::||||:.||:|||:|::|||.:||.:||...||..||:||||.|.|||
Zfish  1451 VIKYKDGNGRQLSEVFIQLPSRKELPEYYELIRKPVDFRKIKERIRSHKYRSLNDLEKDVMLLCQ 1515

  Fly  1501 NAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGG 1565
            |||.:|.|.||||.|||.||.||...||:|....:           |:.|    |:|:.::|| .
Zfish  1516 NAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEEE-----------ESEG----DDSEEEEDD-V 1564

  Fly  1566 DDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQK-KYTI 1629
            |:||:.|      :.:||:|:||::                 ...|...|.:.|..||.: |..:
Zfish  1565 DEGSESE------SRSVKVKIKLSR-----------------KDKAERGKGRRRTGRSSRPKPVV 1606

  Fly  1630 SDDDDDD 1636
            ||||.::
Zfish  1607 SDDDSEE 1613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	13/29 (45%)
		Drf_FH1	251..390	CDD:283903	43/147 (29%)
		HSA	501..573	CDD:214727	46/71 (65%)
		BRK	649..693	CDD:197800	18/45 (40%)
		PHA02934	687..>824	CDD:165245	76/149 (51%)
		SNF2_N	776..1071	CDD:278600	246/294 (84%)
		DEXDc	793..932	CDD:238005	105/138 (76%)
		Helicase_C	1097..1212	CDD:278689	92/114 (81%)
		SnAC	1304..1375	CDD:291293	39/70 (56%)
		Bromo_SNF2L2	1425..1530	CDD:99947	61/111 (55%)
smarca4a	NP_853634.1	Med15	<65..>378	CDD:312941	110/415 (27%)
		QLQ	198..231	CDD:312430	15/32 (47%)
		SMC_N	<388..>595	CDD:330553	141/206 (68%)
		HSA	478..550	CDD:214727	46/71 (65%)
		BRK	630..670	CDD:311469	17/39 (44%)
		SNF2_N	762..>1244	CDD:331286	391/481 (81%)
		SnAC	1301..1368	CDD:317068	36/66 (55%)
		Bromo_SNF2L2	1440..1545	CDD:99947	60/104 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	503	1.000	Domainoid score	I329
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1564	1.000	Inparanoid score	I86
OMA	1	1.010	-	-		QHG52479
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm24871
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840