Protein Alignment brm and Chd1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Alignment Length: 1642
• Identity: 434/1642 - (26%)
• Similarity: 655/1642 - (39%)
• Gaps: 415/1642 - (25%)

  Fly   216 GPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAP 280
            |...|..|:.......|.::......|:.:.:....||.||..:...|.:........|:
  Fly    50 GSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQE----- 109

  Fly   281 PPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQP 345
              .....|...........||.. |:.|........|..|.||.::.: .|..:.....|:....
  Fly   110 --DSSSDGSSGSDSDSDAEGPSD-QRNQSINNANTSSSLPKPEQNEEE-DNETEAGQQQPASDAS 170

  Fly   346 LIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQR----QVPPAG------MPMPKPNRITTVAKPV 400
            ...||.....|..|  .....|:..:....|:|    :.||..      .|.||..:     |..
  Fly   171 ADESSDSSANVSPT--SSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKK-----KTW 228

  Fly   401 GLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCT 465
            ..|.....::.::.::.       ..:|.||..:...:|.             |:|.|......:
  Fly   229 DSDESDESEDSDDEVST-------AQKRKPAATTSRSKLA-------------QQQQRRRVKPFS 273

  Fly   466 RRDTTLETALNIKLYKR--TKRQG----LREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHG 524
            ..|:..:.|     .||  |:|:|    .:||...|..:.:..||.
  Fly   274 SEDSDDDDA-----SKRCATRRKGAAVSYKEASEDEATDSEDLLEF------------------- 314

  Fly   525 KDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQ-ERIEKERMRR---------LMAEDEEGY 579
                |:..:..|..|          |.||.|:|.|. |||..:|..:         :.|.:|.|:
  Fly   315 ----EYDESQAATTA----------ATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGF 365

  Fly   580 --RKLIDQKK----DKRLAFLLSQTD-EYISNLTQMVKQHKD---------DQMKKKEEE---GK 625
              ....|:|:    :....||:.... .||.|..:.....:|         |...|||:|   .:
  Fly   366 DPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWR 430

  Fly   626 RL------------IQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHR 678
            |.            ::.:.|||.|  |..:|.  |:|          .|.|  .||... ::|.:
  Fly   431 RYAGPEDIDYFECQLELQHELLKS--YNNVDR--IIA----------KGSK--PDDGTE-EYLCK 478

  Fly   679 WLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDAT------DKAQATGNDEDAKDLITKAK 737
            |.::                     |..|   :..|||.      .:.....||.::........
  Fly   479 WQSL---------------------PYAE---STWEDAALVLRKWQRCAEQFNDRESSKCTPSRH 519

  Fly   738 VEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNG-TLKEYQIKGLEWLVSLYNNNLNGILADEMG 801
            ....:||.:           ..::..|...:.:| ||::||:.||.||:..:....:.|||||||
  Fly   520 CRVIKYRPK-----------FSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMG 573

  Fly   802 LGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ-- 864
            ||||||||..:..|.....:.||:|.:|||||:..|..||:.|||.:.||:|.|..:.|.|:|
  Fly   574 LGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQY 638

  Fly   865 ----NQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYR 925
                ...:..|||.:|||||.|:|||..|..:||..:::||.||:||....|.:.|. .:...:|
  Fly   639 EWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLK-EFDTNHR 702

  Fly   926 LLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE-QWFNAPFATTGEKVELNEEETILIIRRLHK 989
            ||:|||||||.|.||||||:|::|..|.:...|| |..||            |::.   ..|||:
  Fly   703 LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNA------------EDKG---YTRLHQ 752

  Fly   990 VLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKAL 1054
            .|.|::|||:||:||..||.|||.|::.:|::||:..||.:.:|..   |...|||  :|.....
  Fly   753 QLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNF---DALRKGK--RGSTSTF 812

  Fly  1055 MNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLL 1119
            :|.:::|:|.|||..:.:..|.:.........:.:   |.:.|||..|||::|.:||.|.||||:
  Fly   813 LNIVIELKKCCNHAALIRPSEFELMGLQQDEALQT---LLKGSGKLVLLDKLLCRLKETGHRVLI 874

  Fly  1120 FCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQ 1184
            |.||.:.:.::.|||..|.|.:.||||:.|.|.|.:.|..|||:||..|.|||||||||||:||.
  Fly   875 FSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLA 939

  Fly  1185 TADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ- 1248
            |||||:||||||||..|||||.|||||||:|:|.:.||:|..||||:|:..|:.|:.:|..|||
  Fly   940 TADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQR 1004

  Fly  1249 -----AGMFDQKSTG--SERQQF----LQTIL-------------HQDD------------NEEE 1277
                 ..:.|:...|  |....|    |..||             |.||            ....
  Fly  1005 MDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRN 1069

  Fly  1278 EENEVPDDEMINMM----IARSEEE--------------------------IEIFKRM--DAERK 1310
            |:.|:|.|::::..    ||..|||                          .|.|::.  |.||.
  Fly  1070 EDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERA 1134

  Fly  1311 KEDEEIH--PGRERLIDESELPDWLTKD-------DDEVERFHYQYDED--------TILGRGSR 1358
            ||.|:::  |.|:...:::|......|.       ||......|:...|        ...||.:.
  Fly  1135 KEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTM 1199

  Fly  1359 QRKEVDYTDS---------------------------LTEKEW--LKAI-----DDGAEFDEEEE 1389
            :.|...:||:                           |.||..  ||.:     |...:|..|.:
  Fly  1200 KEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHK 1264

  Fly  1390 EDDSKRKRRKRKNRKEESDDDSLILKRRRRQ--------NLDKRSKKQMHKIMSAVIKHNQDGRT 1446
            |::|          |..:.|::...|:||.:        .:...:||        ::...|:.:.
  Fly  1265 EEES----------KTAATDETPGAKQRRARATFSVKLGGVSFNAKK--------LLACEQELQP 1311

  Fly  1447 LSEPFMKLPSRQRLPDYYEIIKRPV-DIKKILQRIEDCKY------------------ADLNELE 1492
            |:|....:|..::...:....:.|| |:...::  ||.|.                  ..|...:
  Fly  1312 LNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIE--EDTKLLCGIYQYGIGSWEQMKLDPTLKLTD 1374

  Fly  1493 KDFMQLCQNAQIYNEEASLIYLDSIALQKVFV---GARQRITAAADAAAVAAGDNTGEAHGNGGS 1554
            |..:...:..|....:....||..|..:.|.:   |.|::....|..|      |..:|.....|
  Fly  1375 KILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRA------NDAKAASQSAS 1433

  Fly  1555 DNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLAS---APATPTQSSSNVSSGAATTSKK 1616
            ...|....||.|...|...:|.:|.:.|      :.|.||   ||||.....         .:||
  Fly  1434 STIDAKPHDGEDAAGDARTVAESSNSQV------DPSTASPHNAPATEQHGD---------PAKK 1483

  Fly  1617 QTRRKRSQKKYTISDDD 1633
            ..:.|...||.:.||::
  Fly  1484 AKKSKARSKKTSASDNN 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	30/163 (18%)
		PTZ00121	<477..651	CDD:173412	47/220 (21%)
		HSA	501..573	CDD:214727	15/81 (19%)
		BRK	650..691	CDD:462196	7/40 (18%)
		PLN03142	739..>1368	CDD:215601	264/722 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	21/126 (17%)
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	15/81 (19%)
		CD2_tandem	454..508	CDD:349306	16/94 (17%)
		PLN03142	531..>1066	CDD:215601	233/558 (42%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731	17/102 (17%)
		DUF4208	1521..1610	CDD:464035