Protein Alignment brm and Smarca1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001258119.1
• Gene: Smarca1 / 317575
• RGDID: 1561046
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 1025
• Identity: 323/1025 - (31%)
• Similarity: 498/1025 - (48%)
• Gaps: 186/1025 - (18%)

  Fly   709 QPTATEDATDK-----AQATGNDEDAKDLIT-------KAKVEDDEYRTEEQTYYSIAHTIHEKV 761
            ||:|.:..|..     |:.....:|.:.||:       :.:.|:||....|....|   .:..:.
  Rat   114 QPSAQKSPTSPLNMKLARPRVKKDDKQSLISVGDYRHRRTEQEEDEELLSESRKTS---NVCVRF 175

  Fly   762 VEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYL 826
            ....|.:..|.|::|||:||.||:|||.|.:|||||||||||||:|||:|:.||...:...||::
  Rat   176 EVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNFPGPHM 240

  Fly   827 IIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR-RLLQNQMRATKFNVLLTTYEYVIKDKAVLA 890
            ::||.|||.||:.||::|.|::.|:.:.|....| ..::::|...:::|.:|:||.|||:|:|..
  Rat   241 VLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDVRAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFK 305

  Fly   891 KIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSC 955
            |..|:|::|||.||:||...||::::. .:.:..|||||||||||.|.|||||||||||.:|.|.
  Rat   306 KFHWRYLVIDEAHRIKNEKSKLSEIVR-EFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA 369

  Fly   956 STFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMS 1020
            ..|:.||:.......:|          ::.|||.||:||||||:|.:||..||.|.|..|...:|
  Rat   370 DDFDSWFDTKNCLGDQK----------LVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLS 424

  Fly  1021 ALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGH 1085
            .:||..|..:..|.:.:.:.|     ||.....|:|.::||||.||||::|...|......|..|
  Rat   425 KMQREWYTKILMKDIDVLNSS-----GKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEH 484

  Fly  1086 GVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKA 1150
             :||.      |||...||::|.::|....|||:|.|||:.:.|:|||..||.:.|.||||.|..
  Rat   485 -IVSN------SGKMVALDKLLARIKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPH 542

  Fly  1151 EDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRN 1215
            |:|.|.:..|||..|..|:|:|||||||||:||.:||.|:::||||||..||||.||||||||:.
  Rat   543 EEREEAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKK 607

  Fly  1216 EVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG-MFDQKSTGSERQQFLQTILHQDDNEEE-E 1278
            .|||.||:|.|:|||||:..|..||.:|..|||.| :.||:|....:::.||.|.|...:... :
  Rat   608 PVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFACK 672

  Fly  1279 ENEVPDDEMINMMIARSEEEIEIFK-------------RMDAER---KKEDEEIHPGRERLIDES 1327
            |:|:.|::::.::....::..|:.:             |||.|:   |.|.|:.   ||:  .:.
  Rat   673 ESELTDEDIVTILERGEKKTAEMNERMQKMGESSLRNFRMDLEQSLYKFEGEDY---REK--QKL 732

  Fly  1328 ELPDWLTKDDDEVERFHYQYD---------EDTILGRGSRQRKEVDYTD---------SLTEKEW 1374
            ...:|:.....| .:.:|..|         .:..:.:..|..|:.:..|         .|.|||.
  Rat   733 GTVEWIEPPKRE-RKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEI 796

  Fly  1375 L---KAIDDGAEFDEEEEEDD---SKRKRRKRKNRKE-----ESDDDSLILKRRRRQNLDKRSKK 1428
            |   |.|  |.:.....|..:   ::|:.:|:.:..|     ||::...:|    .|.....:|:
  Rat   797 LYYRKTI--GYKVPRNPELPNPAIAQREEQKKIDGAEPLTPQESEEKDKLL----TQGFTNWTKR 855

  Fly  1429 QMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEK 1493
            ..::.:.|..|:.:|                            ||..:.:.:|.....::.|...
  Rat   856 DFNQFIKANEKYGRD----------------------------DIDNVAREVEGKSPEEVMEYSA 892

  Fly  1494 DFMQLCQN--------AQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHG 1550
            .|.:.|..        |||...||.:  ...|:::|.......|..|......:..|.:.|:
  Rat   893 VFWERCNELQDIEKIMAQIERGEARI--QRRISIKKALDAKIARYKAPFHQLRIQYGTSKGK--- 952

  Fly  1551 NGGSDNSDNDDDD---------GGDDGSDDEEIA--------------TTSAAAVKMKLKLNKSL 1592
                 |...::|.         |.|..:..||:.              ..|..|::.:.:.|..:
  Rat   953 -----NYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLI 1012

  Fly  1593 A-------------------SAPATPTQSSSNVSSGAATTSKKQTRRKRS 1623
            :                   .|..||........|...::.||..::.:|
  Rat  1013 SLIEKENMEIEERERAEKKKRATKTPMSQKRKAESATESSGKKDVKKVKS 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	262/665 (39%)
		Bromo_SNF2L2	1425..1530	CDD:99947	17/112 (15%)
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	322/1022 (32%)