Protein Alignment brm and Chd7

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001101376.2
• Gene: Chd7 / 312974
• RGDID: 1311921
• Length: 2985
• Species: Rattus norvegicus
• Alignment Length: 2001
• Identity: 509/2001 - (25%)
• Similarity: 767/2001 - (38%)
• Gaps: 558/2001 - (27%)

  Fly     1 MASPSPANSPMPPPQAP-----------------------------SPMAPPSQSPAPSPHSPYP 36
            :|||.......|.||.|                             |...|.:........:||.
  Rat    97 LASPHSQYHTPPVPQVPHGGGSGGGQMGVYPGMQNDRHGQSFVDGGSMWGPRAVQVPDQIRAPYQ 161

  Fly    37 HQQPGPL-QGPPPPGHP------GAYGHPMQHGPPGQGPPGHHMPPHHQG---------MIFSKG 85
            .|||.|. .|||..|||      |:|   :..|......|...|....||         .|.:.|
  Rat   162 QQQPQPAPSGPPAQGHPQHMQQMGSY---LARGDFSMQQPQQRMSQFSQGQEGLSQGSPFIATSG 223

  Fly    86 P--HMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIV-----------SPGGPPGG----------- 126
            |  |:. .||...||::|...|.:.......|..:           ||..|..|
  Rat   224 PGGHLS-HMPQQSPNIAPSLRHPVQQQFHHHPAALHGESVAHSPRFSPNPPQQGAVRPQTLNFSS 287

  Fly   127 -----PPPPERSSQE-------NLH-ALQRAIDSMEEKGL-------QEDPRYSQLLAMRATS-- 169
                 |.|...:|.:       ||: .|..:....:..||       |..|||...:...:.|
  Rat   288 RSQTVPSPTVNNSGQYSPYPYRNLNQGLVNSTGMNQNLGLTNSTPMNQSVPRYPNAVGFPSNSGQ 352

  Fly   170 -----KHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPP-------------G 216
                 :..|.:|: :|.:.||             :|...|. |.....|||             .
  Rat   353 GLMLQQPIHSSGS-LNQMNTQ-------------TMHPSQP-QGTYASPPPMSPMKAMSNPAGTP 402

  Fly   217 PPIGPPGAPGGP-----------------PPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPA- 263
            ||...||:.|.|                 |||:...||..:.|:..|||.|..|   ..|||..
  Rat   403 PPQVRPGSAGIPMDVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNIQQPRPFMG---MSSTPREL 464

  Fly   264 ---SNPYGPP--------------VPGQKMQVAPPPPHMQQGQPLPPQPPQVG---GPPPIQQQQ 308
               ..|.|.|              :|||:.....||  .||....||..|..|   ..||....|
  Rat   465 TGHMRPNGCPGVGLADAQAIQERLIPGQQHPGQQPP--FQQLPTCPPLQPHPGLHQSSPPHPHHQ 527

  Fly   309 PPQQ----QQQQSQPPPPEPHQHQLPNGGKPL-SMGPSGGQ--------PLIPSSPMQPQVR--- 357
            |..|    .|...|..|...|....|...||: .|....||        ..:||...|||.:
  Rat   528 PWAQLHPSPQNTPQKVPVRQHSPSEPFLEKPVPDMTQVSGQNAQLVKSDDYLPSIEQQPQQKKKK 592

  Fly   358 ---GTLPGMPPGSQVPQ---PGGGPQRQVP----PAGMPMPKPNRITTVAKPVGLDPITLLQERE 412
               ..:....|.....:   |||...:::.    .|.....|..:...|.|    ||..|.:.||
  Rat   593 KKNNHIAAGDPSKGFGKDDFPGGVDNQELSRNSLDASQEETKKRKRPKVKK----DPKELKEPRE 653

  Fly   413 NRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNI 477
            .        :..:..:.|.|..|..      |.:|..|....:..:.   ...::..:..:||..
  Rat   654 K--------KEPKTPKAPKTPKEPK------ERKAKTVTPKPKSSKK---SSNKKPDSEASALKK 701

  Fly   478 KLYKRTKRQGLREARATEKLEK-------------------QQKLEAERKRRQKHLEFLAAVLQH 523
            |:.|     |..|......|:|                   :...:.:|||..:.|||..:. :.
  Rat   702 KVNK-----GKTEGSENSDLDKTPPPSPGPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISD-EE 760

  Fly   524 GKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQER--IEKERMRRLM---------AEDEE 577
            ..|.....|::.:..::           :|:::..:.|.  :||....||:         .|.||
  Rat   761 ADDADAAGRDSPSNTSQ-----------SEQQESVDAEGPVVEKIMSSRLVKKQKESGEEVEVEE 814

  Fly   578 GYRK-------------LIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQ 629
            .|.|             :.|.:||||:                   |.|..:.|.|:.:.|.|.:
  Rat   815 FYVKYKNFSYLHCQWASVEDLEKDKRI-------------------QQKIKRFKSKQGQSKFLSE 860

  Fly   630 FKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDD--APMLKHLHRWLNMHPGWDWIDDE 692
            .:.: |.:.:|:.:|        |:....:.|      ||  .|:..:|.:|.::        ..
  Rat   861 IEDD-LFNPDYVEVD--------RIMDFARST------DDRGEPVTHYLVKWCSL--------PY 902

  Fly   693 EDSCGS--NDDHKPKVE--EQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSI 753
            |||...  .|..:.|:|  |:..:.|..|::.:....|:      .|......||:.
  Rat   903 EDSTWELRQDLDQAKIEEFEKLMSREPETERVERPPADD------WKKSESSREYKN-------- 953

  Fly   754 AHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDR 818
                            |..|:|||::|:.||:..:.|..|.|||||||||||||:|:.: |.:..
  Rat   954 ----------------NNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFL-YEIYL 1001

  Fly   819 KKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMR----ATK 871
            |.:.||:|:|.||||:|||..||..|. .:.||.|.||...||.:|        .|.|    :.|
  Rat  1002 KGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYK 1065

  Fly   872 FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNK 936
            |:.::||:|.::.|...|..|.|:.::|||.||:||.:|||.:.|....: .:::|||||||||.
  Rat  1066 FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL-EHKVLLTGTPLQNT 1129

  Fly   937 LPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKK 1001
            :.||::||:||.||.|.|.:||.|.|.          :|..||.   :::|..:|:|.:|||||:
  Rat  1130 VEELFSLLHFLEPSRFPSETTFMQEFG----------DLKTEEQ---VQKLQAILKPMMLRRLKE 1181

  Fly  1002 EVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKA----LMNTIVQLR 1062
            :||..|..|.|.||:.:::.:|:..|:.:..|.....        .|||.:|    |:||:::||
  Rat  1182 DVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFL--------SKGGGQANVPNLLNTMMELR 1238

  Fly  1063 KLCNHPFMFQHIEEKYCDHTGGHGVVSGPD-----LYRVSGKFELLDRILPKLKATNHRVLLFCQ 1122
            |.||||::....|||..:..........||     :.:.:||..|:|::||||||..||||:|.|
  Rat  1239 KCCNHPYLINGAEEKILEEFKDAHNADSPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQ 1303

  Fly  1123 MTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTAD 1187
            |.:|:.|:||||..|::.|.|:||..:...|...:.:|:...||.|||||.|||||||:||..||
  Rat  1304 MVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAAD 1368

  Fly  1188 TVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMF 1252
            |.:||||||||..|||||.|.|||||...|::.||:|.||.|..:...|..||.:|:.|:|:...
  Rat  1369 TCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSG 1433

  Fly  1253 DQKSTGSERQ---QFLQTILHQDD----NEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERK 1310
            .:.:|...:|   :.::.:|.:..    .:||:|.....:|.|:.::.|....|.|.........
  Rat  1434 RENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTF 1498

  Fly  1311 KEDEEIHPGRE---RLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGS------RQRKEVDYT 1366
            .:...:..|..   .|.|.:....|..|         .:.|.|.:.||.:      |.||:....
  Rat  1499 AKASFVASGNRTDISLDDPNFWQKWAKK---------AELDIDALNGRNNLVIDTPRVRKQTRLY 1554

  Fly  1367 DSLTEKEWLKAIDDGAEFDEEEE--------EDDSKRKRRKRKNRKEES--------DDDSLILK 1415
            .::.|.|.::..|  .|.|.||:        :|.::...|....|.|::        ..|.|...
  Rat  1555 SAVKEDELMEFSD--LESDSEEKPCIKPRRPQDKTQGYARSECFRVEKNLLVYGWGRWTDILSHG 1617

  Fly  1416 RRRRQNLDK-----------------RSKKQMHKIMSAVIKHNQDGRT--------LSEPF---- 1451
            |.:||..:.                 |..:.:...:..:|....||:|        ||.|.
  Rat  1618 RYKRQLTEHDVETICRAILVYCLNHYRGDENIKSFIWDLITPTADGQTRALLNHSGLSAPVPRGR 1682

  Fly  1452 ----MKLPSRQRL-----------PD-------YYEIIKRPVDIKKILQRIEDCKYADLNELEKD 1494
                :|..|.|.:           ||       |.:.:|.  ...|:|.|:....|.....:...
  Rat  1683 KGKKVKAQSMQPVVQDADWLASCNPDALFQEDSYKKHLKH--HCNKVLLRVRMLYYLRQEVIGDQ 1745

  Fly  1495 FMQLCQNA----------QIYNEEASLIYLDSIALQKVFVGA-------------------RQRI 1530
            ..::.:.|          :.::.|....:.|..|.:.:.:|.                   .:|:
  Rat  1746 AEKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERV 1810

  Fly  1531 TAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDE--EIATTSAAAVKMKLKLNKSLA 1593
             ...||.|:||.....:...:||         |||:...:||  |...|.|   ..|.::::...
  Rat  1811 -GMPDAKAIAAEQRGTDMLADGG---------DGGEFDREDEDPEYKPTRA---PFKDEIDEFAN 1862

  Fly  1594 SAP----------ATPTQSSSNVSSGA---ATTSKKQTRRKR----SQKKY 1627
            |.|          :|...|.||...|.   ..||...||.:|    .|:.|
  Rat  1863 SPPEDKEDSMEAQSTGKHSESNAELGQLYWPNTSSLTTRLRRLITAYQRSY 1913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	6/28 (21%)
		Pro-rich	<247..401	CDD:464580	49/200 (25%)
		PTZ00121	<477..651	CDD:173412	39/216 (18%)
		HSA	501..573	CDD:214727	14/82 (17%)
		BRK	650..691	CDD:462196	7/42 (17%)
		PLN03142	739..>1368	CDD:215601	239/665 (36%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/167 (14%)
Chd7	NP_001101376.2	Med15	<2..>318	CDD:312941	49/224 (22%)
		Atrophin-1	194..>567	CDD:460830	90/393 (23%)
		CD1_tandem_CHD5-9_like	785..849	CDD:349315	17/82 (21%)
		CD2_tandem_CHD5-9_like	868..925	CDD:349310	16/78 (21%)
		PLN03142	956..>1555	CDD:215601	236/631 (37%)
		BRK	2551..2592	CDD:462196
		BRK	2630..2674	CDD:197800