DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and HELLS

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001275996.1	Gene:	HELLS / 3070	HGNCID:	4861	Length:	884	Species:	Homo sapiens

Alignment Length:	920	Identity:	273/920 - (29%)
Similarity:	436/920 - (47%)	Gaps:	202/920 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 AQLARMNKAVMNHHANAEREQ------KKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFL 594
            |.:.:::.||:......|.||      ::|::.:||.||.......|..||         ||..|
Human    16 AMVEQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYR---------RLQHL 71

  Fly   595 LSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQ 659
            |.:::.|...|...::|.:.::.||||:     ::.|||.|.    :...:.||.|.....|:.:
Human    72 LEKSNIYSKFLLTKMEQQQLEEQKKKEK-----LERKKESLK----VKKGKNSIDASEEKPVMRK 127

  Fly   660 CTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATG 724
            ..|::   |::..:..:            :..||....:..:.|...:|..::|....:..|
Human   128 KRGRE---DESYNISEV------------MSKEEILSVAKKNKKENEDENSSSTNLCVEDLQ--- 174

  Fly   725 NDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVV--EQASIMVNGTLKEYQIKGLEWLVSL 787
            .::|:..:| |.:: .:..|...:.::......:.:.|  :|......|.::.||::|:|||..|
Human   175 KNKDSNSII-KDRL-SETVRQNTKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRML 237

  Fly   788 YNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVS 852
            :.|.:|||||||||||||:|.|:.:. ||.::.|.||:|:..||||||||:.||:::.|.:..:.
Human   238 WENGINGILADEMGLGKTVQCIATIA-LMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPDIPTML 301

  Fly   853 YKGSPQGRRLLQNQMRATK-----FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKL 912
            |.|:.:.|:.|...:...|     ..|::|::|..::|:..|....|||:|:|||||:||..|:|
Human   302 YHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRL 366

  Fly   913 TQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFN-APFATTGEKVELN 976
            .:.|. .:.|..:||||||||||.|.|||:|||||||.:|....:||.||: ...:.|.|.:...
Human   367 IRELK-RFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAK 430

  Fly   977 EEETILI------------------------------------------IRRLH---KVLRPFLL 996
            |.|..::                                          :.:||   ::|.||||
Human   431 EREQNVLHMLHQERIPRMYVSEFTDEGFFEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLL 495

  Fly   997 RRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK---------GKHGKGGAK 1052
            ||||.:|..::|.|.|.::...:|..|.:.|..:.::.:....||.:         |:..:...|
Human   496 RRLKSDVALEVPPKREVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRK 560

  Fly  1053 A--------------------------------------------LMNTIVQLRKLCNHPFMFQH 1073
            :                                            |.|.::.|||.||||::.::
Human   561 SINYSKIDDFPNELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEY 625

  Fly  1074 -----IEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDY 1133
                 .:|...|.          :|...||||.:|||:||:||...|:||||.|||..:.|:.||
Human   626 PIDPVTQEFKIDE----------ELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDY 680

  Fly  1134 LGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNP 1198
            ...|.|.:.||||:....:|.:.:..||. ..:||:||:||||||||:||..||||:|:||||||
Human   681 CHLRDFNFSRLDGSMSYSEREKNMHSFNT-DPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNP 744

  Fly  1199 HQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTG-SERQ 1262
            ..|||||||.|||||...|.|.||:|.|:::::|:..|..|..:::.:|....|....:| :..:
Human   745 QSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLSK 809

  Fly  1263 QFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDES 1327
            .||.                            .:|.:|:.|..|.||     ||...||::|.:.
Human   810 NFLD----------------------------PKELMELLKSRDYER-----EIKGSREKVISDK 841

  Fly  1328 ELPDWLTKDD 1337
            :|...|.:.|
Human   842 DLELLLDRSD 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	11/42 (26%)
		BRK	649..693	CDD:197800	4/43 (9%)
		PHA02934	687..>824	CDD:165245	39/138 (28%)
		SNF2_N	776..1071	CDD:278600	126/398 (32%)
		DEXDc	793..932	CDD:238005	62/143 (43%)
		Helicase_C	1097..1212	CDD:278689	65/114 (57%)
		SnAC	1304..1375	CDD:291293	11/34 (32%)
		Bromo_SNF2L2	1425..1530	CDD:99947
HELLS	NP_001275996.1	SNF2_N	221..>869	CDD:331286	226/677 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910