Protein Alignment brm and Hells

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001099841.1
• Gene: Hells / 294071
• RGDID: 1309820
• Length: 837
• Species: Rattus norvegicus
• Alignment Length: 878
• Identity: 274/878 - (31%)
• Similarity: 442/878 - (50%)
• Gaps: 150/878 - (17%)

  Fly   537 QLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEY 601
            ::|...:..:...|..|.|::.|.|.:|||  |:::.|..:.:.:...:.:.:||..||.:::.|
  Rat    16 EMAEQTEPAVITPAMLEEEEQLEAEGLEKE--RKMLEEARKSWDRESTEIRYRRLQHLLEKSNIY 78

  Fly   602 ISNLTQMVKQHKDDQMKKKEE-----------EGKRLIQFKKELLMSGEYIGIDEGSIVADMRVH 655
            ...|...::|.:.::.||||:           |||.||.            |.:|.:::...|
  Rat    79 SKFLLTKMEQQQLEEQKKKEKLEKKKRSLKVTEGKNLID------------GNEENTVMKKKR-- 129

  Fly   656 VVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKA 720
                  |::   |::..:..             :..:|:.......||...:|..:.|....:..
  Rat   130 ------GRE---DESYNISE-------------VMSKEEILSVAKKHKDNEDENSSTTNLCVEDL 172

  Fly   721 QATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVV--EQASIMVNGTLKEYQIKGLEW 783
            |   .::|:..:| |.:: ....|...:.::......:.:.|  :|......|.::.||::|:||
  Rat   173 Q---KNKDSNSMI-KDRL-SQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEW 232

  Fly   784 LVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAV 848
            |..|:.|.:|||||||||||||:|.|:.:. ||.::.|.||:|:..||||||||:.||:::.|.:
  Rat   233 LRMLWENGINGILADEMGLGKTVQCIATIA-LMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEI 296

  Fly   849 GVVSYKGSPQGRRLLQNQMRATK-----FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNH 908
            ..:.|.|:.|.||.|...:...:     ..|::|::|..::|:..|....|||:|:|||||:||.
  Rat   297 PTLLYHGNRQERRKLVKNIHKRQGTLQIHPVVITSFEIAMRDQNALQHCYWKYLIVDEGHRIKNM 361

  Fly   909 HCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFN-APFATTGEK 972
            .|:|.:.|. .:.|..:||||||||||.|.|||:|||||||.:|....:||.||: ...:.|.|.
  Rat   362 KCRLIRELK-RFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAED 425

  Fly   973 VELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLL 1037
            :...|.|. .::..||::|.||||||||.:|..::|.|.|.::...:...|.:.|..:.::.:..
  Rat   426 IIAKEREQ-NVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIAN 489

  Fly  1038 TDGS-EK--------GKHGKGGAKA---------------------------------------- 1053
            ..|| ||        |:..:...|:
  Rat   490 MFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVKRERTVVEGNIPIESE 554

  Fly  1054 ----LMNTIVQLRKLCNHPFMFQH-----IEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPK 1109
                |.|.::.|||.||||:|.::     .:|...|.          :|...||||.:|||:||:
  Rat   555 VNLKLQNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDE----------ELVTNSGKFLILDRMLPE 609

  Fly  1110 LKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLST 1174
            ||...|:||:|.|||..:.|:.||...|.|.:.||||:....:|.:.:..||. ..:||:||:||
  Rat   610 LKKRCHKVLVFSQMTSMLDILMDYCHLRNFTFSRLDGSMSYSEREKNIYSFNT-DPEVFLFLVST 673

  Fly  1175 RAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYK 1239
            ||||||:||..||||:|:||||||..|||||||.|||||...|.|.||:|.|:::::|:..|..|
  Rat   674 RAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAK 738

  Fly  1240 LNMDEKVIQAGMFDQKSTG-SERQQFLQT-----ILHQDDNEEE---EENEVPDDEMINMMIARS 1295
            ..:::.:|....|....:| |:.:.||..     :|...|.|.|   ...:|..||.:.:::.||
  Rat   739 RKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRS 803

  Fly  1296 EEEIEIFKRMDAERKKEDEEIHPGRERLIDESE 1328
                ::..:|.|.|..:::   .|..::::.||
  Rat   804 ----DLIDQMKASRPIKEK---TGIFKILENSE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	29/124 (23%)
		HSA	501..573	CDD:214727	10/35 (29%)
		BRK	650..691	CDD:462196	3/40 (8%)
		PLN03142	739..>1368	CDD:215601	233/665 (35%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Hells	NP_001099841.1	DEXHc_HELLS_SMARCA6	219..452	CDD:350767	106/235 (45%)
		PLN03142	220..>797	CDD:215601	222/590 (38%)