Protein Alignment brm and Chd5

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_006538992.1
• Gene: Chd5 / 269610
• MGIID: 3036258
• Length: 1955
• Species: Mus musculus
• Alignment Length: 1435
• Identity: 374/1435 - (26%)
• Similarity: 584/1435 - (40%)
• Gaps: 408/1435 - (28%)

  Fly   319 PPPPEPHQHQLPNGGKPLSMGPSGGQPLIP---SSPMQPQVRGTLPGM---PPGSQVPQPGGGPQ 377
            ||.||     :||           |:.|.|   ..|::.:|:..|...   ||   .|...|.|.
Mouse   447 PPLPE-----IPN-----------GEWLCPRCTCPPLKGKVQRILHWRWTEPP---APFVVGLPG 492

  Fly   378 RQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAA 442
            .:|.| |||.|:              |:..:.|||      ..::...|.....:..::|:|:.
Mouse   493 PEVEP-GMPPPR--------------PLEGIPERE------FFVKWAGLSYWHCSWVKELQLEL- 535

  Fly   443 IELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAER 507
              ...:...|:||:..|:      .....:       |......|     .:||.:.:..|.|:.
Mouse   536 --YHTVMYRNYQRKNDMD------EPPPFD-------YGSGDEDG-----KSEKRKNKDPLYAKM 580

  Fly   508 KRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLM 572
            :.|                   |:|........|...::||
Mouse   581 EER-------------------FYRYGIKPEWMMVHRILNH------------------------ 602

  Fly   573 AEDEEGYRKLIDQKKDKRLAFLLSQTDE----YISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKE 633
            :.|::|....:.:.||........:.||    |..||.|....|::..:.:.....|||:  ||
Mouse   603 SFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLV--KK- 664

  Fly   634 LLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGS 698
                                        ||||
Mouse   665 ----------------------------GKKL--------------------------------- 668

  Fly   699 NDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVE 763
            .||.:.|..:.|                           :.|...:.::|.:|..|
Mouse   669 KDDKQEKPPDTP---------------------------IVDPTVKFDKQPWYIDA--------- 697

  Fly   764 QASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLII 828
                 ..|||..||::||.||...:....:.|||||||||||:|||..:..|.......||||:.
Mouse   698 -----TGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVS 757

  Fly   829 VPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMRA------------TKFN 873
            .||||:.||..|||.|||...||:|.|..:.|.:::        |.:|.            .||:
Mouse   758 APLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFH 822

  Fly   874 VLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLP 938
            ||||:||.:..|:|:|..|:|..:::||.||:||:..|..:|||::.| .|:||||||||||.|.
Mouse   823 VLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKI-DYKLLLTGTPLQNNLE 886

  Fly   939 ELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEV 1003
            ||:.|||||.|..|.:...|.:.|          .::::|:.   |::||.:|.|.:|||||.:|
Mouse   887 ELFHLLNFLTPERFNNLEGFLEEF----------ADISKEDQ---IKKLHDLLGPHMLRRLKADV 938

  Fly  1004 EHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAK--ALMNTIVQLRKLCN 1066
            ...:|.|.|.|::.::|.:|:..||      .:||...| ..:.|||..  :|:|.::.|:|.||
Mouse   939 FKNMPAKTELIVRVELSQMQKKYYK------FILTRNFE-ALNSKGGGNQVSLLNIMMDLKKCCN 996

  Fly  1067 HPFMF--QHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTI 1129
            ||::|  ..:|.....    :|...|..|.:.|||..||.::|.||:...||||:|.|||:.:.:
Mouse   997 HPYLFPVAAVEAPVLP----NGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDL 1057

  Fly  1130 IEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDS 1194
            :||:|.:..:.|.|:||......|.|.:.:|||.|:..|.|||||||||||:||.|||||:|:||
Mouse  1058 LEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDS 1122

  Fly  1195 DWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGS 1259
            |||||.|:||..|||||||..:|.:.|.:|..||||||...|:.|:.:...|::.|:  ...:||
Mouse  1123 DWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGL--GSKSGS 1185

  Fly  1260 ERQQFLQTILH------------------------------------------------QDDNEE 1276
            ..:|.|..||.                                                ..||::
Mouse  1186 MTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKD 1250

  Fly  1277 EEENEV--PDDEMINMMIARSE------------EEIEIFKRMDAERKKED--EEIHPGRERLID 1325
            .|::.|  .||..|:.::.|::            |.:..||......::||  ||:.  ||.:..
Mouse  1251 VEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVE--REVIKQ 1313

  Fly  1326 ESEL-PDWLTKDDDEVERFHYQYDEDTI---LGRGSRQRKEVDYTDSLTEK----EWLKAIDDG- 1381
            |..: ||:..|    :.|.||:..::.:   ||:|.|.||:|:|.|:..|.    ||...:.|.
Mouse  1314 EENVDPDYWEK----LLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQGACEWQDELSDNQ 1374

  Fly  1382 AEF---DEEEEEDDSKR------KRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAV 1437
            :|:   .|:|:||..:|      :|:.|:..|.:.|.....|..|...|::             |
Mouse  1375 SEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIE-------------V 1426

  Fly  1438 IKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDF------- 1495
            :..|...|   :.|:....|..:|        |.|.......:.|.:    .:.||:|
Mouse  1427 LGFNARQR---KAFLNAIMRWGMP--------PQDAFNSHWLVRDLR----GKSEKEFRAYVSLF 1476

  Fly  1496 -MQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDN 1559
             ..||:.    ..:.:..:.|.:..:.:   :||.:.......::.........|.||.....|.
Mouse  1477 MRHLCEP----GADGAETFADGVPREGL---SRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDL 1534

  Fly  1560 DDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQ 1624
            ..:  |.:|....|:.::..     ...:..|.|..|..|...:..:.:....|.:|::..::.:
Mouse  1535 VPE--GAEGKKPGEVISSDP-----NTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPK 1592

  Fly  1625 KKYTI 1629
            |...|
Mouse  1593 KSLEI 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	23/87 (26%)
		PTZ00121	<477..651	CDD:173412	28/177 (16%)
		HSA	501..573	CDD:214727	8/71 (11%)
		BRK	650..691	CDD:462196	4/40 (10%)
		PLN03142	739..>1368	CDD:215601	254/720 (35%)
		Bromo_SNF2L2	1425..1530	CDD:99947	17/112 (15%)
Chd5	XP_006538992.1	CHDNT	148..203	CDD:462357
		PHD1_CHD_II	347..389	CDD:277006
		PHD2_CHD_II	420..462	CDD:277007	9/30 (30%)
		CD1_tandem_CHD3-4_like	467..546	CDD:349314	21/105 (20%)
		CD2_tandem_CHD3-4_like	591..644	CDD:349309	13/76 (17%)
		PLN03142	700..>1218	CDD:215601	218/544 (40%)
		DUF1087	1300..1353	CDD:461922	20/58 (34%)
		CHDII_SANT-like	1394..1534	CDD:461920	27/174 (16%)
		LGT	<1535..1687	CDD:469786	11/70 (16%)
		CHDCT2	1734..1879	CDD:462358