Protein Alignment brm and RAD54B

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_036547.1
• Gene: RAD54B / 25788
• HGNCID: 17228
• Length: 910
• Species: Homo sapiens
• Alignment Length: 924
• Identity: 240/924 - (25%)
• Similarity: 386/924 - (41%)
• Gaps: 210/924 - (22%)

  Fly   511 QKHLEFLAAVLQHGKDLREFHRNNKAQ---------LARMNKAVMNHHANAEREQKKEQERIEKE 566
            |..|...:..|...:..||.:..:...         ||.::.....|.|..|....||||    |
Human    57 QNDLRICSLNLPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKEQE----E 117

  Fly   567 RMRRLMAEDEEGYRKLI----DQKKDKRL---AFLLSQTDEYI-SNLTQMVKQHKD------DQM 617
            :...|:.     |..::    .:||.|:.   |.|:.:...:| .||     :.||      .:.
Human   118 KSDSLVK-----YFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNL-----EGKDIGRGIGYKF 172

  Fly   618 KKKE--EEGKRLIQFKKEL----------LMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDA 670
            |:.|  |||:.|:...||:          ..||....:..||........|..:|..........
Human   173 KELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCK 237

  Fly   671 PMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITK 735
            |..|...:           :|.::....:|.:.|.....|...::    .|...|    |:....
Human   238 PSSKENRQ-----------NDFQNCKPRHDPYTPNSLVMPRPDKN----HQWVFN----KNCFPL 283

  Fly   736 AKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLY--------NNNL 792
            ..|..|.        |.:.|                 |:.:|.:|   ::.||        |...
Human   284 VDVVIDP--------YLVYH-----------------LRPHQKEG---IIFLYECVMGMRMNGRC 320

  Fly   793 NGILADEMGLGKTIQTISLVTYLMDRKKVMGPY---------LIIVPLSTLPNWVLEFEKWAPAV 848
            ..|||||||||||:|.|||:..|    :..|||         ||:.|.|.:.||..||:||..:.
Human   321 GAILADEMGLGKTLQCISLIWTL----QCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSE 381

  Fly   849 GVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLT 913
            .:..:......:  ::..:::..::||:.:||.:::....:..|::..:|.|||||:||...|.|
Human   382 RIKIFTVDQDHK--VEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEGHRLKNSAIKTT 444

  Fly   914 QVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEE 978
            ..| .......|::|||||:||.|.|.:||::|:.|.|..|.|::.:.:..|...:.|. ..:||
Human   445 TAL-ISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREP-SASEE 507

  Fly   979 ETILIIRR---LHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVL---L 1037
            |..|..||   |..:...|:|||.::.:...||.|:|.::.|...|||..||:.:.:..|:   |
Human   508 EKELGERRAAELTCLTGLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCL 572

  Fly  1038 TDGSEKGKHGKGGAKALMNTIVQLRKLCNHP-FMFQHIEEKYCDHTGG--------HGVVS---- 1089
            ....|...|        :..|..|:|||||| .:|..|:||.|..|..        .|::|
Human   573 QGLLENSPH--------LICIGALKKLCNHPCLLFNSIKEKECSSTCDKNEEKSLYKGLLSVFPA 629

  Fly  1090 --GPDLY--RVSGKFELLDRILP---KLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGT 1147
              .|.|:  :.|||.::|.::|.   :|:.| .:|:|....||.:.|:::......:.|.||||.
Human   630 DYNPLLFTEKESGKLQVLSKLLAVIHELRPT-EKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQ 693

  Fly  1148 TKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIG 1212
            |....|.:::..||::.|..|:||||::|||:||||.....::::|.||||..|:||..|..|.|
Human   694 TPISQRQQIVDGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDG 758

  Fly  1213 QRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEE 1277
            |:..|.:.||:|..::||:|     |:..:.::.:...:.|...| ||..||
Human   759 QKYPVHIYRLLTTGTIEEKI-----YQRQISKQGLCGAVVDLTKT-SEHIQF------------- 804

  Fly  1278 EENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVER 1342
                 ..:|:.|:.......:......:|.|  ...||:|.|                  |.:|:
Human   805 -----SVEELKNLFTLHESSDCVTHDLLDCE--CTGEEVHTG------------------DSLEK 844

  Fly  1343 F----------HYQ 1346
            |          |:|
Human   845 FIVSRDCQLGPHHQ 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	39/174 (22%)
		HSA	501..573	CDD:214727	16/70 (23%)
		BRK	650..691	CDD:462196	4/40 (10%)
		PLN03142	739..>1368	CDD:215601	189/661 (29%)
		Bromo_SNF2L2	1425..1530	CDD:99947
RAD54B	NP_036547.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		HepA	<296..794	CDD:440319	167/522 (32%)
		DEXHc_RAD54B	296..530	CDD:350824	79/244 (32%)
		DEGH box	431..434		2/2 (100%)