Protein Alignment brm and hrp1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_593660.1
• Gene: hrp1 / 2542363
• PomBaseID: SPAC1783.05
• Length: 1373
• Species: Schizosaccharomyces pombe
• Alignment Length: 1375
• Identity: 371/1375 - (26%)
• Similarity: 605/1375 - (44%)
• Gaps: 350/1375 - (25%)

  Fly   460 EFVQCTRRDTTLETALN-----------------IKLYKRTKRQGLREARATEKLEKQQKLEAER 507
            |.|..|...|.:.:||:                 .:...|.||...|:...||..|.:..:..:|
pombe    67 EIVTSTANSTVVSSALSTPKIDDAQNSDDVRVDGTRRSSRAKRPVYRDFSYTEIDEHEIPIPKKR 131

  Fly   508 KRR------------------QKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAER 554
            |.:                  ::|...:.:.  .|.::|...|::|.:....|:  ...:.:.|.
pombe   132 KSKPAPKQKKSVASDDEDAYDKRHRFSINSA--SGTEIRTSLRSSKGKSVNYNE--QEFYDDFED 192

  Fly   555 EQKKEQERIEKE----------RMRRLMAEDEE---GYRKLIDQKKDKRLAFLLSQTDEYISNLT 606
            |:::.:|::|:|          ..:|..|:|::   .|:.||   |.:.::.|.:..::| |.|:
pombe   193 EEEEVEEQVEEEYEPIIDFVLNHRKRADAQDDDPKSSYQYLI---KWQEVSHLHNTWEDY-STLS 253

  Fly   607 QM---------VKQH-------KDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVH 655
            .:         :||:       ::|.....|:.....|:.:::.::..||              .
pombe   254 SVRGYKKVDNYIKQNIIYDREIREDPTTTFEDIEALDIERERKNMLFEEY--------------K 304

  Fly   656 VVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKA 720
            :||:....: |.::. ..::..:|..:         ..|:|               ..||| |..
pombe   305 IVERIVASE-TNEEG-KTEYFVKWRQL---------PYDNC---------------TWEDA-DVI 342

  Fly   721 QATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLV 785
            .:...:|..:.|    :.|:..|...:..:|: ....:.|:.:|.|.:..|.::::|:.|:.|:.
pombe   343 YSMAPNEVYQFL----QRENSPYLPYKGVFYN-TRPPYRKLEKQPSYIKGGEIRDFQLTGINWMA 402

  Fly   786 SLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGV 850
            .|::.|.|||||||||||||:||:..::||:...|..||:||:|||||:|.|......|.|.:..
pombe   403 YLWHRNENGILADEMGLGKTVQTVCFLSYLVHSLKQHGPFLIVVPLSTVPAWQETLANWTPDLNS 467

  Fly   851 VSYKGSPQGRR-------LLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNH 908
            :.|.|:.:.|.       .|....|..|||:|||||||::|||..|..|:|:|:.|||.||:||.
pombe   468 ICYTGNTESRANIREYEFYLSTNSRKLKFNILLTTYEYILKDKQELNNIRWQYLAIDEAHRLKNS 532

  Fly   909 HCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKV 973
            ...|.:.| :.:....|||:|||||||.|.||.:|:|||:|..|....  |..|:.|.|
pombe   533 ESSLYETL-SQFRTANRLLITGTPLQNNLKELASLVNFLMPGKFYIRD--ELNFDQPNA------ 588

  Fly   974 ELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLT 1038
               |:|.  .||.|.:.|:||:||||||:||..||.|.|.|::.::|.:|...||::.:|.....
pombe   589 ---EQER--DIRDLQERLQPFILRRLKKDVEKSLPSKSERILRVELSDMQTEWYKNILTKNYRAL 648

  Fly  1039 DGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRV------- 1096
            .|...|:    |..:|:|.:|:|:|:.|||::|....||:         :.|..:.|.
pombe   649 TGHTDGR----GQLSLLNIVVELKKVSNHPYLFPGAAEKW---------MMGRKMTREDTLRGII 700

  Fly  1097 --SGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRK 1159
              |||..|||::|.:||...||||:|.||.:.:.|:.:|:..|.:.|.|||||..|..|...:..
pombe   701 MNSGKMVLLDKLLQRLKHDGHRVLIFSQMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDH 765

  Fly  1160 FNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMT 1224
            |||..|..|||||||||||||:||.|||||:||||||||..||||..|||||||:|.|.|.|.::
pombe   766 FNAPDSPDFVFLLSTRAGGLGINLNTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLS 830

  Fly  1225 VNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQF----LQTIL--------HQDDNEEE 1277
            .::|||.||..||.|:.::..:|..|: .:||..|:..::    |..||        ...:|:::
pombe   831 KDTVEEDILERARRKMILEYAIISLGV-TEKSKNSKNDKYDAQELSAILKFGASNMFKATENQKK 894

  Fly  1278 EENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKD------ 1336
            .||...||     :::.:|         |.:...:......|.|..:.:.|:.|:..:|
pombe   895 LENMNLDD-----ILSHAE---------DRDSSNDVGGASMGGEEFLKQFEVTDYKAEDLNWDDI 945

  Fly  1337 --DDEVERFHYQYDEDTILG-----RGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSK 1394
              ::|:||..   :|:.:|.     ...|:|:|                      :||.|.|:..
pombe   946 IPEEEMERIE---EEERMLAAQRAKEEERERRE----------------------EEERENDEDH 985

  Fly  1395 RKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQR 1459
            ..|..::..|      |:..:::||:.:.:  :|::..:..|:||..    .:.|.|..:.....
pombe   986 PSRTYKRTTK------SITKRQQRREEMVR--EKEIRLLYRAMIKFG----LVDERFDTIVKEAE 1038

  Fly  1460 LPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNA---------------------- 1502
            |        :..|.|:|.            .|..|.::.|..|
pombe  1039 L--------QATDPKRIY------------SLSADMVKACDEAVERLGADDTKNKQPRKAILIEF 1083

  Fly  1503 ----QIYNEEASLIYLDSIALQKVFVG---ARQRI-------------TAAADAAAVAAGDNTGE 1547
                .|..|..:|...|...|.:.:.|   .:|.|             ....:.:.:.||.|
pombe  1084 KGVKNINAETVTLRVKDLTHLHRAYKGLDPLKQIIGYPIRSVHSWNCSWGIKEDSMLLAGIN--- 1145

  Fly  1548 AHGNGGSDNSDNDDDDG------GDDGSDDEEIATTSAA---------------------AVK-- 1583
            .||.|......||.|.|      .|:..:|:|.....:|                     .||
pombe  1146 KHGFGCWQAIKNDPDLGLHDKIFLDEAKNDKESRYVPSAVHLVRRGEYLLSVVREHPDLFVVKTD 1210

  Fly  1584 --MKLKLNKSLASAPATPTQSSSNVSS--GAATTSKKQTRRKRSQKKYTISDDDDDDMDXLPLGV 1644
              .|.|.|:.      .||:||:..::  |:.:.:||.:|.|:.:::.|...|:..     |.|.
pombe  1211 QPTKRKYNRK------APTKSSTRQTTLDGSISNTKKSSRTKKKKEEETNRGDETS-----PEGT 1264

  Fly  1645 IFKRGSSDVE 1654
            :   |..:||
pombe  1265 V---GEDEVE 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	38/220 (17%)
		HSA	501..573	CDD:214727	14/99 (14%)
		BRK	650..691	CDD:462196	4/40 (10%)
		PLN03142	739..>1368	CDD:215601	249/669 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	21/133 (16%)
hrp1	NP_593660.1	CD1_tandem_CHD1_yeast_like	207..266	CDD:349312	11/62 (18%)
		CD2_tandem	302..355	CDD:349306	14/97 (14%)
		PLN03142	377..>909	CDD:215601	232/573 (40%)
		Cdh1_DBD_1	1010..1090	CDD:408024	14/103 (14%)
		CHDCT2	1132..>1159	CDD:462358	7/29 (24%)