Protein Alignment brm and snf22

DIOPT Version :9

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_588472.2
• Gene: snf22 / 2538881
• PomBaseID: SPCC1620.14c
• Length: 1680
• Species: Schizosaccharomyces pombe
• Alignment Length: 1705
• Identity: 606/1705 - (35%)
• Similarity: 854/1705 - (50%)
• Gaps: 409/1705 - (23%)

  Fly     2 ASPSPANSPM----PPPQAPSPMAPPSQSPAPSPH-SPYPHQQPGPLQGPPPPGHPGAYGHPMQH 61
            |||:..|:|:    ..|.|||.:.|.:.:.|.|.: ..|.:|.  ..|....|.:..||
pombe   134 ASPNIMNAPLQRDTSVPPAPSMVHPHTNTNANSNNLKVYANQL--SQQNTSNPTYHNAY------ 190

  Fly    62 GPPGQGPPGHHMPPHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPP------NAPTQPCIVSP 120
                           ....:...|..|....|||    :||     ||      |:.......||
pombe   191 ---------------DMASMMKNGSRMNNSFPPT----TPY-----PPANDTTVNSSLPHSFASP 231

  Fly   121 GGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQ 185
            .           |:.|..|.:|....|::                                  |.
pombe   232 S-----------STFEQPHTVQSRAPSVD----------------------------------TT 251

  Fly   186 ITAYRLLARNKPISMQMQQAL-----------QAAQQQPPPGPPIGPP----------------- 222
            .:::...|||.|.::.|||.:           ..:...||.|..:..|
pombe   252 SSSHSFSARNIPANVSMQQQMGRRGSIPVNPSTFSASSPPSGSMLASPYNGYQNDAASFAHSKLP 316

  Fly   223 -----------------GAPGG----PPPGS----------QHAGQPPVPPQQQQQPPPSAGT-P 255
                             ||.|.    |.|.:          |.:...|.|...:...||||.: .
pombe   317 SSANPNTPFNSTATVDVGAAGSHFPYPQPSNLDAINAKTYFQSSSNSPAPYVYRNNLPPSATSFQ 381

  Fly   256 PQCSTPPASNP-----------YGPP-----------VPGQKMQVAPPPPHMQQGQ--PLPPQ-- 294
            |..|..|:.:|           ..|.           ||..|:   ||...:...|  .|..|
pombe   382 PSSSRSPSVDPNTVKSAQHIPRMSPSPSASALKTQSHVPSAKV---PPTSKLNHAQLAMLKSQIV 443

  Fly   295 ------PPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGP-------SGGQPL 346
                  .|....||.:||....:.....::..|..|.|..:|.........|       :...|.
pombe   444 AYNCLNSPNGQVPPAVQQAIFGRVYGASNEVSPSMPFQQNVPQMSSVKKDTPTRDANMRTSKAPY 508

  Fly   347 IPSSPMQPQVRGTLPGMP-PGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAK----PVG----- 401
            |.:.|.|.|.|.....:| ....:.:|...|        ||:.:....|.|||    |..
pombe   509 IQNIPNQFQRRAYSATIPVKNESLAKPSVSP--------MPLQQSTGKTEVAKRAQFPTNVNYSS 565

  Fly   402 -LDPITLLQ--------------------------------ERENRIAARISLRMQ--ELQRLPA 431
             :||.|.::                                ..|..||..|:.|:.  |.:..|.
pombe   566 CVDPRTYVKTPIPFSKFSSSENLSLIPSLLPPSISWDDVFLSSEIAIACSIANRIDFLEKENRPK 630

  Fly   432 TMSEDL----RLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKL-YKRTKRQGLREA 491
            ::::.:    :.::.||||.||:|..||.|| |.:......:....|.|::| ::..|||.::||
pombe   631 SVNKKILQQDKSKSMIELRCLRLLEKQRSLR-ETINSVIPHSDSLAAGNLRLMFRNVKRQTMQEA 694

  Fly   492 RATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDL-REFHRNNKAQLARMNKAVMNHHANAERE 555
            .....|.::||.|...::::|.|..|.:::.|.|.: .:..:.|||:..|. |.::|.||:.|:|
pombe   695 NLVLALAEKQKTEHAMRQKEKLLTHLRSIMLHRKSIVTKVDKQNKAKTQRC-KDIINFHAHLEKE 758

  Fly   556 QKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKK 620
            :||..||..::|::.|.|:||..|.:|:|:.||.|:..||.|||:|:.|||:.|:
pombe   759 EKKRIERSARQRLQALRADDEAAYLQLLDKAKDTRITHLLKQTDQYLENLTRAVR---------- 813

  Fly   621 EEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPG 685
                                                ::|.                    |:|.|
pombe   814 ------------------------------------IQQS--------------------NIHSG 822

  Fly   686 WDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTY 750
                  .....|||....    |.|.:.||              |:|                .|
pombe   823 ------NTSGKGSNSAEL----EAPISEED--------------KNL----------------DY 847

  Fly   751 YSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYL 815
            :.:||.|||: |||..|.|.||||:||:|||||::||||||||||||||||||||||||:.:|||
pombe   848 FKVAHRIHEE-VEQPKIFVGGTLKDYQLKGLEWMLSLYNNNLNGILADEMGLGKTIQTIAFITYL 911

  Fly   816 MDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYE 880
            :::|...||:|||||||||.||::|||||||:|..::|||.||.|:.||:|:|::.|||||||:|
pombe   912 IEKKNQQGPFLIIVPLSTLTNWIMEFEKWAPSVKKIAYKGPPQLRKTLQSQIRSSNFNVLLTTFE 976

  Fly   881 YVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLN 945
            |:|||:.:|::|:|.:||||||||:||...|||..|:|:|.:.|||:||||||||.|||||||||
pombe   977 YIIKDRPLLSRIKWVHMIIDEGHRIKNTQSKLTSTLSTYYHSQYRLILTGTPLQNNLPELWALLN 1041

  Fly   946 FLLPSIFKSCSTFEQWFNAPFATTG--EKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLP 1008
            |:||.||.|..:|::|||.|||.||  :|:.|||||.:|||:||||||||||.|||||:||.:||
pombe  1042 FVLPKIFNSIKSFDEWFNTPFANTGGQDKIGLNEEEALLIIKRLHKVLRPFLFRRLKKDVEKELP 1106

  Fly  1009 DKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQH 1073
            ||||.:|||.:|.||..||:.|:..|:|..||.:    ||.|.|.|.||::||:|:|||||:|:.
pombe  1107 DKVEKVIKCPLSGLQLKLYQQMKKHGMLFVDGEK----GKTGIKGLQNTVMQLKKICNHPFIFED 1167

  Fly  1074 IEEKYCDHTGGHGVVSGPD-LYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWR 1137
            : |:..|.:|     :..| |:|.:|||||||||||||..|.|:.|:|.||||.|||:||||..:
pombe  1168 V-ERAIDPSG-----TNVDLLWRAAGKFELLDRILPKLFLTGHKTLMFFQMTQIMTIMEDYLRSK 1226

  Fly  1138 QFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDL 1202
            .:.||||||:||::||..||.:||...|||::|:||||||||||||||||||:|||:||||||||
pombe  1227 NWKYLRLDGSTKSDDRCSLLAQFNDPKSDVYIFMLSTRAGGLGLNLQTADTVIIFDTDWNPHQDL 1291

  Fly  1203 QAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQT 1267
            |||||||||||..|||:|||:|..|:||.||:.|:|||::|.||||||.||.|||..||:.||::
pombe  1292 QAQDRAHRIGQTKEVRILRLITEKSIEENILSRAQYKLDLDGKVIQAGKFDNKSTPEEREAFLRS 1356

  Fly  1268 ILHQDDNEEEE--ENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIH-PGR--ERLIDES 1327
            :|..|.:::.:  ..|:.||| :|.:|:|::||:.:||::|.||...|  |: .|:  |||:..:
pombe  1357 LLEHDGDDDHDLTYGELQDDE-LNELISRTDEELVLFKKLDKERAATD--IYGKGKPLERLLTVN 1418

  Fly  1328 ELPDWLTKDDDEVERFHYQYD---EDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEE 1389
            ||||:...   ||:.|..|..   ||..|.|..|:|..:.||: ||..| |..:||
pombe  1419 ELPDFYKV---EVDSFAVQSSSELEDQYLERKRRRRNSISYTE-LTLDE-LNTVDD--------- 1469

  Fly  1390 EDDSKRKRRKRKNRKEESDDDSL--------ILKRRRRQNLDKRSKKQMHKIMSAVIK-----HN 1441
            ...:...|::.:.||:.:...||        .|.|..|:|.....:|.:.:....:.:     .:
pombe  1470 PSSTLMPRKRGRPRKKTNSGSSLSTPLSQESSLARSGRKNTPSYKQKALRRYCMEIFERLYNLQS 1534

  Fly  1442 QDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYN 1506
            :|||.::..|:..|:|:..||||.|||||:.:.||.:.|::.:|.|:.||..|||.:..||..||
pombe  1535 EDGRFVNGLFLYPPNRKLYPDYYIIIKRPIALGKIKRNIKNDRYGDVGELIADFMLMFNNAYTYN 1599

  Fly  1507 EEASLIYLDSIALQK 1521
            ||.|::|.|:..::|
pombe  1600 EEHSIVYEDAKLMEK 1614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	5/29 (17%)
		Drf_FH1	251..390	CDD:283903	36/179 (20%)
		HSA	501..573	CDD:214727	24/72 (33%)
		BRK	649..693	CDD:197800	4/43 (9%)
		PHA02934	687..>824	CDD:165245	59/136 (43%)
		SNF2_N	776..1071	CDD:278600	192/296 (65%)
		DEXDc	793..932	CDD:238005	89/138 (64%)
		Helicase_C	1097..1212	CDD:278689	83/114 (73%)
		SnAC	1304..1375	CDD:291293	28/76 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	36/102 (35%)
snf22	NP_588472.2	NHS	216..>396	CDD:291922	36/224 (16%)
		DUF4452	<229..292	CDD:291292	16/107 (15%)
		QLQ	428..463	CDD:214931	8/34 (24%)
		HepA	582..1345	CDD:223627	409/881 (46%)
		HSA	711..775	CDD:284861	20/64 (31%)
		DEXDc	889..1028	CDD:238005	89/138 (64%)
		Helicase_C	1187..1301	CDD:278689	83/113 (73%)
		COG5076	1395..1673	CDD:227408	76/236 (32%)
		SnAC	1398..1463	CDD:291293	26/70 (37%)
		Bromo_SNF2	1518..1620	CDD:99950	35/97 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I115
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	911	1.000	Inparanoid score	I47
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm47338
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X702
TreeFam	1	0.960	-	-
	12	11.820