DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brm and Chd2

DIOPT Version :10

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_001074814.2 Gene:Chd2 / 244059 MGIID:2448567 Length:1827 Species:Mus musculus


Alignment Length:1433 Identity:387/1433 - (27%)
Similarity:611/1433 - (42%) Gaps:383/1433 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 KRQGLREARATEKL-------EKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNN--KAQLA 539
            ||:|.|:.:..||.       |::|...||.:..||          .||..|...|..  |.|:.
Mouse   138 KRRGQRQLKKQEKWKQDPSEDEQEQGTSAESEAEQK----------KGKARRPVPRRTVPKPQVK 192

  Fly   540 RMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEY--- 601
            :..|        .:|.::|:||..:.:      .:|:|..::...::..|.:::  .:.|::   
Mouse   193 KQPK--------IQRGKRKKQESSDDD------DDDDEAPKRQTRRRAAKNVSY--KEDDDFETD 241

  Fly   602 ISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLT 666
            ..:|.:|..:..|:|....|...|.|          ...:| .:|:..|...|:.||      ..
Mouse   242 SDDLIEMTGEGGDEQQDNSETIEKVL----------DSRLG-KKGATGASTTVYAVE------AN 289

  Fly   667 GD---------DAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQA 722
            ||         :...:::|.:|    .||.:|....:|                  ||:..:.:.
Mouse   290 GDPSDDFDTEREEGEVQYLIKW----KGWSYIHSTWES------------------EDSLQQQKV 332

  Fly   723 TG---------NDEDAKDLITKAKVEDDEY-------RTEEQTYYSI------------------ 753
            .|         .:::.|..:.|...||.||       .:|....|.|                  
Mouse   333 KGLKKLENFKKKEDEVKQWLGKVSPEDVEYFSCQQELASELNKQYQIVERVIAVKTSKSTLGQTD 397

  Fly   754 --AH-----------------------------------------TIHE------------KVVE 763
              ||                                         :.|.            |.::
Mouse   398 FPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNSKTIPTRECKALK 462

  Fly   764 QASIMV------------NGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLM 816
            |....|            :..|::||::||.||...:..:.:.||||||||||||||||.::||.
Mouse   463 QRPRFVALKKQPAYLGGESLELRDYQLEGLNWLAHSWCKSNSVILADEMGLGKTIQTISFLSYLF 527

  Fly   817 DRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ------NQMRATKFNVL 875
            .:.::.||:||:||||||.:|..|||.|||.:.||.|.|....|..::      :|.:..|||.|
Mouse   528 HQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNAL 592

  Fly   876 LTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPEL 940
            :||||.::|||.||..|.|.::.:||.||:||....|.:.| ..:.:.:|||:|||||||.|.||
Mouse   593 ITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTL-IDFKSNHRLLITGTPLQNSLKEL 656

  Fly   941 WALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEH 1005
            |:||:|::|..|:....||:       ..|:..|...:.       |||||.||||||:||:||.
Mouse   657 WSLLHFIMPEKFEFWEDFEE-------DHGKGRENGYQS-------LHKVLEPFLLRRVKKDVEK 707

  Fly  1006 QLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFM 1070
            .||.|||.|::.:|||||:..|     |.:|..:.....|..:|.....:|.:::|:|.|||.::
Mouse   708 SLPAKVEQILRVEMSALQKQYY-----KWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYL 767

  Fly  1071 FQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLG 1135
            .:..|:.  :...|..|:.  .|.|.|||..|||::|.:|:...:|||:|.||.:.:.|:.:||.
Mouse   768 IKAPEDS--ERESGQEVLQ--SLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLT 828

  Fly  1136 WRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQ 1200
            .:.:.:.||||:.|.|.|.:.|..|||.||:.|.|||||||||||:||.:|||||||||||||..
Mouse   829 IKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQN 893

  Fly  1201 DLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ------AGMFDQKSTGS 1259
            |||||.|||||||:.:|.:.||:|..:|||.|:..|:.|:.:|..|||      ..:.:..|..|
Mouse   894 DLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTVLENNSGRS 958

  Fly  1260 ERQQF------------LQTILHQDDNEEEEENEVPDDEMINMMIAR--------SEEEIEIFKR 1304
            ....|            .:.:..:.:.||.|..|:..||::.:...|        ::|.:..||.
Mouse   959 NSNPFNKEELTAILKFGAEDLFKEIEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKV 1023

  Fly  1305 MDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILG--RGSRQRKEVDYTD 1367
            .:....:::||:.....:..||. :|:...|..:|.|| ..:.:|..:|.  |.|.::.:.:.:|
Mouse  1024 ANFATMEDEEELEERPHKDWDEI-IPEEQRKKVEEEER-QKELEEIYMLPRIRSSTKKAQTNDSD 1086

  Fly  1368 SLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKN--RKE--ESDDDS-------------LILK 1415
            |.||.:........:|.:.::.:||.|.|||.|..  ||:  |...|:             |.|:
Mouse  1087 SDTESKRQAQRSSASESETDDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLE 1151

  Fly  1416 R-----RRRQNLD------KRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKR 1469
            |     |..:.:|      ||..:.:|....:.::..::....|....|.|.::|.|. .:|...
Mouse  1152 RLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYEEQLKESTSEGKGPGKRRGPT-IKISGV 1215

  Fly  1470 PVDIKKILQRIEDCKYADLN-----ELEKDFMQLCQ----------------------------N 1501
            .|::|.|:|..|:.:....:     |.:|.:...|:                            |
Mouse  1216 QVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGN 1280

  Fly  1502 AQIYNEEASLIYLDSI--------------------ALQKVFVGARQRITAAADAAAVAAGDNT- 1545
            .::...:..|...|.|                    .|:.:..|..::.|       ||:|:.. 
Mouse  1281 WELIKTDPELKLTDKILPVETDKKPQGKQLQTRVDYLLKLLRKGLEKKGT-------VASGEEAK 1338

  Fly  1546 -----------------GEAHG--NGGSDNSDNDDDDG--GDDGSDDEEIATTSAAAVKMKLKLN 1589
                             .:.||  .....:|||..::|  .|||.:      .|....|.|.|.|
Mouse  1339 LKKRKPRVKKENKAPRLKDEHGLEPASPRHSDNPSEEGEVKDDGLE------KSPTKKKQKKKEN 1397

  Fly  1590 KSLASAPATPTQSSSNVSSGAATTSKKQ----------TRRKRSQ---------KKYTISDDDDD 1635
            |.....|.:..:..........:..||:          ::.||||         :...|.:|:||
Mouse  1398 KENKEKPVSSRKDREGDKERKKSKDKKEKVKGGDGKSSSKSKRSQGPVHITAGSEPVPIGEDEDD 1462

  Fly  1636 DMD 1638
            |:|
Mouse  1463 DLD 1465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 173..202 CDD:462622
Pro-rich <247..401 CDD:464580
PTZ00121 <477..651 CDD:173412 36/178 (20%)
HSA 501..573 CDD:214727 16/73 (22%)
BRK 650..691 CDD:462196 11/49 (22%)
PLN03142 739..>1368 CDD:215601 258/754 (34%)
Bromo_SNF2L2 1425..1530 CDD:99947 22/157 (14%)
Chd2NP_001074814.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..264 32/151 (21%)
CD1_tandem_CHD1-2_like 259..343 CDD:349313 20/122 (16%)
CD2_tandem_CHD1-2_like 376..447 CDD:349308 5/70 (7%)
DEXHc_CHD2 464..700 CDD:350812 104/250 (42%)
PLN03142 468..>1021 CDD:215601 231/576 (40%)
DEAH box 617..620 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1124 25/95 (26%)
CDH1_2_SANT_HL1 1130..1218 CDD:465731 15/88 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1329..1465 31/148 (21%)
CHD1 helical C-terminal domain (CHCT). /evidence=ECO:0000250|UniProtKB:O14646 1464..1566 1/2 (50%)
DUF4208 1471..1553 CDD:464035
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1638
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1827
Blue background indicates that the domain is not in the aligned region.

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