Protein Alignment brm and Ercc6l

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_666347.2
• Gene: Ercc6l / 236930
• MGIID: 2654144
• Length: 1240
• Species: Mus musculus
• Alignment Length: 1107
• Identity: 278/1107 - (25%)
• Similarity: 455/1107 - (41%)
• Gaps: 268/1107 - (24%)

  Fly   704 PKVEEQPTATEDATDKAQATGNDED-------AKDLITKAKV------------------EDDEY 743
            |::.|..........:|...|:.|:       |||:....||                  :|||:
Mouse    15 PQLAESYLRYVQEAKEAAKNGDLEESLKLFNLAKDIFPTKKVMSRIQKLQEALEQLAEEEDDDEF 79

  Fly   744 RTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLY-NNNLNGILADEMGLGKTIQ 807
            .....:...:...::||            |.|:|.:|:.:|.||| :....|||||:||||||:|
Mouse    80 IDVCSSGLLLYRELYEK------------LFEHQKEGIAFLYSLYKDGRKGGILADDMGLGKTVQ 132

  Fly   808 TISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRR---LLQNQMRA 869
            .|:.::.:.| ..::...|:|:|.:.:..||.||.||.|.:.|.::.||.:..|   |.:.|.|.
Mouse   133 IIAFLSGMFD-ASLVNHVLLIMPTNLINTWVNEFAKWTPGMRVKTFHGSSKSERTRSLTRIQQRN 196

  Fly   870 TKFNVLLTTYEYVIKDKAVLAKIQ-----WKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLT 929
               .|::|||:.::.:...||...     |.|:|:||.|::|:...| :.|......|..|||||
Mouse   197 ---GVVITTYQMLLNNWQQLASFNGQAFVWDYVILDEAHKIKSASTK-SAVCARAIPASNRLLLT 257

  Fly   930 GTPLQNKLPELWALLNFLLP-SIFKSCSTFEQWFNAPF-------ATTGEK---VELNEEETILI 983
            |||:||.|.|||:|.:|... |:..:..||:..:..|.       ||.|||   ::::|
Mouse   258 GTPVQNNLQELWSLFDFACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISE------ 316

  Fly   984 IRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIK---------CDMSALQR-----------VLYK 1028
              .|.::::|:.|||.|:||:.:..|..|..:.         |||.:|.|           .|.:
Mouse   317 --NLMEIIKPYFLRRTKEEVQTKKADNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQE 379

  Fly  1029 HMQSKGVLLTDGSEKGKHGKGGAKALMNT------IVQLRKLCNHP-----------------FM 1070
            .:..|.|.|       .|.|   :.||.|      :..|:|||:||                 |.
Mouse   380 EIYRKFVSL-------DHIK---ELLMETRSPLAELGVLKKLCDHPRLLSARACRLLNLGTATFS 434

  Fly  1071 FQHIEEKYCDHTGGHGVVSGPD--LYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDY 1133
            .|. |.:..|.:..:.:...||  |.:.|||...|..:|.:|:...|:.|:|.|..:.:.|||..
Mouse   435 AQD-ENEQEDVSNMNSIDHLPDKTLIQESGKMIFLMSLLERLQDEGHQTLVFSQSIKILNIIERL 498

  Fly  1134 LGWRQFGYLRLDGT-TKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWN 1197
            |..:.|..||:||| |...:|.:.::.|. :..:..||||:|:.||:||.|..|..|||||..||
Mouse   499 LKNKHFKTLRIDGTVTHLWEREKRIQLFQ-QNKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWN 562

  Fly  1198 PHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQ 1262
            |..|.||.||.:||||:..|.|.||:|..:|||:|.....:|    :.:|      :::||.::.
Mouse   563 PATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFK----DSLI------RQTTGEKKN 617

  Fly  1263 QFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEI--HPGRERLID 1325
            .|    .:....|.:|...|.|       :.:|..:::: :.:.|.:::.||::  |.....|:.
Mouse   618 PF----RYFTKQELKELFTVGD-------LQKSATQMQL-QCLHAAQRRSDEKLDEHIAYLHLLG 670

  Fly  1326 ESELPD---WLTKDDDEVERFHYQYDEDTILGR--------GSRQRKEVDYTDSLTEKEWLKAID 1379
            .:.:.|   ..|:|....|......|...|..|        .|..:..|....:..|:.||||
Mouse   671 IAGISDHDLMFTRDLSVKEELDMLEDSQYIHQRVQKAQFLVESESQNTVQRQTTGIEETWLKA-- 733

  Fly  1380 DGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNL----------------DKRSKK 1428
                     :|..|::|::..:..|.:.....|:.|..:.:.:                :.:...
Mouse   734 ---------QEFPSQQKKKGTEFNKPQPQPSRLLTKPTQVEAISSQMASITICDQSAESEPQEHS 789

  Fly  1429 QMHKIMSAVIKHN----QDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLN 1489
            ::|.:.|....|:    .|..|::.          ||...|.|.. |....:|...:... |:.:
Mouse   790 EVHDVTSLQGSHHFNSTSDAGTIAS----------LPQGAESIGE-VSTDSLLSPAKGFA-AEND 842

  Fly  1490 ELEKDFMQLCQNAQIYNEE-ASLIYL----------------DSIALQKVFVGARQRITAAADAA 1537
            .::|..:|.....:..:|. .|..||                ||:.|......|.:.....:|..
Mouse   843 AMQKKGLQASPGQEAPSENLGSFHYLPRESSKASLGPNLDLQDSVVLYHRSPTANENQNLESDVP 907

  Fly  1538 AVAAGDNTGE-------AHGNGGSDNSDNDD----------------DDGGD----------DGS 1569
            .:...|:..|       |...........||                :|..|          :..
Mouse   908 MIEISDDLSEPPSALQGAQAIEAQLELKEDDPLKSPPQYACDFNLFLEDSADTRQNLSSKFLEHV 972

  Fly  1570 DDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDD 1634
            :.|:...:.||..:.|..|..||.|:|     .|...|...:..:|.:|||       .:|||:|
Mouse   973 EKEKSLQSPAANSRAKSALTLSLDSSP-----KSDEESEVISVKTKSKTRR-------ILSDDED 1025

  Fly  1635 DD 1636
            :|
Mouse  1026 ED 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	207/707 (29%)
		Bromo_SNF2L2	1425..1530	CDD:99947	22/125 (18%)
Ercc6l	NP_666347.2	TPR 1	21..54		6/32 (19%)
		HepA	<96..613	CDD:440319	181/563 (32%)
		DEXHc_ERCC6L	97..329	CDD:350759	84/244 (34%)
		DEAH box	229..232		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..760		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..813		5/34 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..879		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..1085		20/66 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1104..1185
		TPR 2	1191..1224