Protein Alignment brm and Chd3

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_017169944.1
• Gene: Chd3 / 216848
• MGIID: 1344395
• Length: 2111
• Species: Mus musculus
• Alignment Length: 1827
• Identity: 461/1827 - (25%)
• Similarity: 723/1827 - (39%)
• Gaps: 462/1827 - (25%)

  Fly    21 APPSQSPAPSPHSPYPHQQPGPLQGPPPPGH------PGAYG-HPMQHGPPGQ--GPPGHHMPPH 76
            :|||....|.|        |.||..||||..      |.|.| ...:.||..|  ..||   .|.
Mouse    65 SPPSCHLFPPP--------PPPLPPPPPPDKDDIRLLPSALGVKKRKRGPKKQKENKPG---KPR 118

  Fly    77 HQGMIFSK-----------------GPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPP 124
            .:..:.|:                 |...|     |||.....:.|.......|:.  ...|...
Mouse   119 KRKKLDSEEEFGSERDEYREKSESGGSEYG-----TGPGRKRRRKHREKKEKKTKR--RKRGEGD 176

  Fly   125 GGPPPPERSSQENLHALQRAIDSMEEKGLQED-------PRYSQLLAMRATSKHQHLNGNQVNLL 182
            ||....|:.|...| .|...::.:|....:||       ..:||.:......|:..:   .::.:
Mouse   177 GGHKQVEQKSSATL-LLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI---PMSKM 237

  Fly   183 RTQITA-YRLLARNKP-------ISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPP 239
            .|.:.| :|..:.|.|       ::.....|..|..:|.........|.||.||||..      |
Mouse   238 MTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPPAL------P 296

  Fly   240 VPPQQQQQPPPSAGTPPQCSTPPASNP------YGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQV 298
            .||..:.||||..    :..|.....|      ..|.||..:.::        :|:.:.|...::
Mouse   297 PPPAPEIQPPPIR----RAKTKEGKGPGHKRRNKSPRVPDGRKKL--------RGKKMAPLKIKL 349

  Fly   299 G---------GPPPIQQQQPPQQQQQQSQPPPPEPHQHQ-LPNG---GKPLSMGPSG-------G 343
            |         |....|.::..:.:.::|.......|... .|:|   .|.|..|..|       |
Mouse   350 GLLGGKRKKAGSCAFQSEEGHEPEAEESDLDSGSVHSASGWPDGPVRAKKLKRGRPGRKKKKVLG 414

  Fly   344 QPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKP-----VGLD 403
            .|.:..   :.:|.|.........:|.|.||                ..|.....|     |.||
Mouse   415 CPAVTG---EEEVDGYETDHQDYCEVCQQGG----------------EIILCDTCPRAYHLVCLD 460

  Fly   404 PITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRD 468
            |                    ||.|.|                         :.:.....|
Mouse   461 P--------------------ELDRAP-------------------------EGKWSCPHC---- 476

  Fly   469 TTLETALNIKLYKRTKRQGLR-EARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHR 532
                           :::|:: ||:..|:..:::..|.|::....|:|:.......|
Mouse   477 ---------------EKEGVQWEAKEEEEEYEEEGEEGEKEEEDDHMEYCRVCKDGG-------- 518

  Fly   533 NNKAQLARMNKAVMNHH-----------ANAEREQKKEQERIEKERMRRLM-------------A 573
                :|...:..:.::|           .|.|....:....:.|.|:::::             .
Mouse   519 ----ELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP 579

  Fly   574 EDEEGY------RKLIDQKKDKRLAFL---------LSQTDEYISNLTQMVK----QHKDDQMK- 618
            :..:|.      |.|  |.:.:|..|:         .|...|....:..:|.    |.|:|..:
Mouse   580 QQADGNPDVPPPRPL--QGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEP 642

  Fly   619 ------KKEEEGKRLIQFKKELLMSGEYIGIDE-----GSIVADMRVH-VVEQCTGKKLTGDDAP 671
                  ..|::||.    .|..:....|..::|     |.....|.|| ::.....||  |:
Mouse   643 PPLDYGSGEDDGKS----DKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSMDKK--GN--- 698

  Fly   672 MLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPK--------VEEQPTATEDATDKAQATGNDED 728
             ..:|.:|.::.......:::|.:....||||..        :.|.|........|.:....|..
Mouse   699 -YHYLVKWKDLPYDQSTWEEDEMNIPEYDDHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGP 762

  Fly   729 AKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLN 793
                 ..:...|...:.|.|..:..|              ..|||..||::||.||...:....:
Mouse   763 -----PSSPTNDPTVKYETQPRFITA--------------TGGTLHMYQLEGLNWLRFSWAQGTD 808

  Fly   794 GILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQ 858
            .|||||||||||||||..:..|.......||:|:..||||:.||..||:.|||...||:|.|...
Mouse   809 TILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKD 873

  Fly   859 GRRLLQ--------NQMRA------------TKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGH 903
            .|.:::        |.::.            .||:||||:||.:..|:|.|..|:|..:::||.|
Mouse   874 SRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAH 938

  Fly   904 RMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFAT 968
            |:||:..|..:|||.:.| .::||||||||||.|.||:.|||||.|..|.:...|.:.|
Mouse   939 RLKNNQSKFFRVLNGYKI-DHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF------ 996

  Fly   969 TGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSK 1033
                .::::|:.   |::||.:|.|.:|||||.:|...:|.|.|.|::.::|.:|:..||:
Mouse   997 ----ADISKEDQ---IKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKY---- 1050

  Fly  1034 GVLLTDGSEK-GKHGKGGAKALMNTIVQLRKLCNHPFMF--QHIEEKYCDHTGGHGVVSGPDLYR 1095
              :||...|. ...|.|...:|:|.::.|:|.||||::|  ..:|.....    .|...|..|.:
Mouse  1051 --ILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLP----SGAYEGGALIK 1109

  Fly  1096 VSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKF 1160
            .|||..||.::|.|||...||||:|.|||:.:.::||:|.:..:.|.|:||......|.|.:.:|
Mouse  1110 SSGKLLLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRF 1174

  Fly  1161 NAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTV 1225
            ||.|:..|.|||||||||||:||.|||||:|||||||||.|:||..|||||||.|:|.:.|.:|.
Mouse  1175 NAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTR 1239

  Fly  1226 NSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTI-------LHQDDNE---EEEEN 1280
            .||||||...|:.|:.:...|::.|:  ....||..:|.|..|       |.:|:||   :||::
Mouse  1240 ASVEERITQVAKRKMMLTHLVVRPGL--GSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDS 1302

  Fly  1281 EV--PDDEMINMMIARSE------------EEIEIFKRMDAERKKED--EEIHPGRERLIDESEL 1329
            .|  .|:|.|..::.|::            |.:..||......::||  |||.  ||.:..|..:
Mouse  1303 SVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIE--REIIKQEENV 1365

  Fly  1330 -PDWLTKDDDEVERFHYQYDEDTI---LGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEF---DEE 1387
             ||:..|    :.|.||:..::.:   ||:|.|.||:|:|.|:..|.:     |:.:|:   .||
Mouse  1366 DPDYWEK----LLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQ-----DNQSEYSVGSEE 1421

  Fly  1388 EEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMS--AVIKHNQDGRTLSEP 1450
            |:||..:|...:|::            ||:.|...||.....:.::..  .|:..|...|   :.
Mouse  1422 EDEDFDERPEGRRQS------------KRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQR---KA 1471

  Fly  1451 FMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDF--------MQLCQNAQIYNE 1507
            |:....|..:|        |.|.......:.|.:    .:.||:|        ..||:.    ..
Mouse  1472 FLNAVMRWGMP--------PQDAFTTQWLVRDLR----GKTEKEFKAYVSLFMRHLCEP----GA 1520

  Fly  1508 EASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDE 1572
            :.|..:.|.:..:.:   :||::.......::.........|.||....               .
Mouse  1521 DGSETFADGVPREGL---SRQQVLTRIGVMSLVKKKVQEFEHINGRWSM---------------P 1567

  Fly  1573 EIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQT---RRKRSQKKYTISDDDD 1634
            |:....:|..|...:.:....::|.||..|::|    :..|||..|   ..|....:..:..||.
Mouse  1568 ELMPDPSAESKRSSRASSPTKTSPTTPEASTTN----SPCTSKPATPAPSEKGDGVRTPLDKDDT 1628

  Fly  1635 DDMDXLP 1641
            ::.:..|
Mouse  1629 ENQEEKP 1635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	5/36 (14%)
		Pro-rich	<247..401	CDD:464580	32/184 (17%)
		PTZ00121	<477..651	CDD:173412	34/229 (15%)
		HSA	501..573	CDD:214727	11/95 (12%)
		BRK	650..691	CDD:462196	8/41 (20%)
		PLN03142	739..>1368	CDD:215601	256/681 (38%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/114 (16%)
Chd3	XP_017169944.1	CHDNT	200..253	CDD:462357	10/55 (18%)
		PHD1_CHD_II	434..476	CDD:277006	14/102 (14%)
		PHD2_CHD_II	510..552	CDD:277007	5/53 (9%)
		CD1_tandem_CHD3-4_like	557..635	CDD:349314	11/79 (14%)
		CD2_tandem_CHD3-4_like	680..734	CDD:349309	13/59 (22%)
		PLN03142	771..>1325	CDD:215601	230/593 (39%)
		DEXHc_CHD3	788..1019	CDD:350813	96/244 (39%)
		DUF1087	<1366..1409	CDD:461922	16/46 (35%)
		CHDII_SANT-like	1430..1569	CDD:461920	27/187 (14%)
		PHA03169	1589..>1759	CDD:223003	13/51 (25%)
		CHDCT2	1791..1917	CDD:462358