Protein Alignment brm and ssl-1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001255179.1
• Gene: ssl-1 / 190954
• WormBaseID: WBGene00007027
• Length: 2395
• Species: Caenorhabditis elegans
• Alignment Length: 1796
• Identity: 412/1796 - (22%)
• Similarity: 620/1796 - (34%)
• Gaps: 726/1796 - (40%)

  Fly   295 PPQVGGPPPIQQ-QQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRG 358
            ||....|||||: .||.:.:.:.|:                    |.:..||
 Worm   155 PPTPAPPPPIQKTMQPIEVKIEDSE--------------------GSNTAQP------------- 186

  Fly   359 TLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARIS-LR 422
                    |.:|..|||.                 |.|.:..         :||..:.|||: ||
 Worm   187 --------SVLPSCGGGE-----------------TNVERAA---------KREAHVLARIAELR 217

  Fly   423 MQEL---QRLPAT-------------------MSEDLRLQAAIELRALRVLNFQRQLRMEFVQCT 465
            ...|   .|||..                   |:.|.|.:...:.:..:|:       ...:...
 Worm   218 KNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVI-------AHAIAKQ 275

  Fly   466 RRDTTLETALNIKLYKRTKRQGLREAR---------------ATEK---LEKQQKLEAE-RKRRQ 511
            .||..:|       .:|...:.::|.|               :|:|   :..::.||:. ||.|.
 Worm   276 HRDKQIE-------IERAAEREIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEVLESRLRKARN 333

  Fly   512 KHLEF-------LAAVLQHG----------------KDLREFHRNNKAQLARMNKAVMNHHANAE 553
            |||.|       ::.::|.|                || .||........:...:.:    ||||
 Worm   334 KHLMFVIGQVDEMSNIVQEGLVSSSKSPSIASDRDDKD-EEFKAPGSDSESDDEQTI----ANAE 393

  Fly   554 REQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYIS--NLTQMVKQHKD-D 615
            :.||||..|.|.:.::.....|.:.              ||.:...||:.  .|||     :| :
 Worm   394 KSQKKEDVRQEVDALQNEATVDMDD--------------FLYTLPPEYLKAYGLTQ-----EDLE 439

  Fly   616 QMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWL 680
            :||:::.|                                  ||...|:..||:...:
 Worm   440 EMKREKLE----------------------------------EQKARKEACGDNEEKM------- 463

  Fly   681 NMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDE-----DAKDLITKAKVED 740
                       |.|...|:|..||.........|...|.....||.:     :..|.: |...:|
 Worm   464 -----------EIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDGNGDGHGVLENVDYV-KLNSQD 516

  Fly   741 DEYRTEEQTYYSIAHTIHE--------------KVVEQASIMVNGTLKEYQIKGLEWLVSLYNNN 791
            .:.|.:|     :|:...|              :|......::.|.|:|||:.||:|:|:||..|
 Worm   517 SDERQQE-----LANIAEEALKFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKN 576

  Fly   792 LNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGS 856
            ||||||||||||||||||||:.::...:.:.||:||:||.|.:.||.:||:||.||:.:::|.|:
 Worm   577 LNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGT 641

  Fly   857 PQGR-RLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQ-VLNTH 919
            .:.| ...:..|:...|:|.:|:|:.|.:|.....:..|:|:|:||...:||...:..| :||..
 Worm   642 AKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVR 706

  Fly   920 YIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILII 984
              |..|||||||||||.|.|||:|::||:|:||.|...|:.||:.|.  || .:|.|.|....:|
 Worm   707 --ARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPL--TG-MMEGNMEFNAPLI 766

  Fly   985 RRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKG 1049
            .|||||||||:|||||||||.|||:|.|:|:.|.:|..||.||....|:      .|.|.....|
 Worm   767 GRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSR------RSTKENLKSG 825

  Fly  1050 GAKALMNTIVQLRKLCNHPFMFQ------------------------------------------ 1072
            ...:::|.::||||.||||.:|:
 Worm   826 NMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDVPARLFEISQQDPSSSSASQIPEIFN 890

  Fly  1073 -------------------------------------------------HIEEK----------- 1077
                                                             |.||.
 Worm   891 LSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFNRTAFVAKNPHTEESEDEGVMRSRVL 955

  Fly  1078 ---------------------------YC----------------DHTG--------GHGVVSGP 1091
                                       .|                |.:|        |.|||...
 Worm   956 PKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNMANVGRGVVRLD 1020

  Fly  1092 DLYRVS----------------------------------------------------------- 1097
            |..|:|
 Worm  1021 DSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVALVR 1085

  Fly  1098 ----------------------------------------------------------------- 1097
                                                                             
 Worm  1086 EEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLSNI 1150

  Fly  1098 -------------------------------------GKFELLDRILPKLKATNHRVLLFCQMTQ 1125
                                                 ||.:.|..:|.:|....||.|:|.||::
 Worm  1151 ELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSK 1215

  Fly  1126 CMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVV 1190
            .:.:::.:|....:.|.||||||..|.|..::.:||| ...||.|:||||:||:|:||..||||:
 Worm  1216 MLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNA-DPKVFCFILSTRSGGVGVNLTGADTVI 1279

  Fly  1191 IFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVI-QAGMFDQ 1254
            .:||||||..|.|||||.|||||...|.:.||::..::||.||..|..|..:.|..| :||...:
 Worm  1280 FYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDEAGFTPE 1344

  Fly  1255 --KSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDE-EI 1316
              |.:.|.|..|        |.|..|...|.|     :....||:|:|:     |..|.||| ::
 Worm  1345 FFKQSDSIRDLF--------DGENVEVTAVAD-----VATTMSEKEMEV-----AMAKCEDEADV 1391

  Fly  1317 HPGRERL---------IDESELPDWLTKDDDE---------------VERFHYQYDEDTILGRGS 1357
            :..:..:         .||..||.......||               :||:...:.|........
 Worm  1392 NAAKIAVAEANVDNAEFDEKSLPPMSNLQGDEEADEKYMELIQQLKPIERYAINFLETQYKPEFE 1456

  Fly  1358 RQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNL 1422
            .:.||.:.......:||.|.::|.|..|.:                    |.|||:|.
 Worm  1457 EECKEAEALIDQKREEWDKNLNDTAVIDLD--------------------DSDSLLLN------- 1494

  Fly  1423 DKRSKKQMHKIMSAV--IKHNQDGRTLSE--PFMKLPSRQ--------RLPDYYEIIKRPVDIKK 1475
            |..:....::..|.:  ||...:   |.:  |....||..        |:.|         |...
 Worm  1495 DPSTSADFYQSSSLLDEIKFYDE---LDDIMPIWLPPSPPDSDADFDLRMED---------DCLD 1547

  Fly  1476 ILQRIEDCKYADLNEL---------EKDFMQLCQNAQIYNEEASLIYLDSI--ALQKVFVGARQR 1529
            ::..||....|.|.::         ||...|...||  :|:..|....:|:  |:.|.....:..
 Worm  1548 LMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNA--FNDILSAKEKESVYDAVNKCLQMPQSE 1610

  Fly  1530 ITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLAS 1594
            ...|..||:.|..:     |.:...|::..|                         .|:..||
 Worm  1611 AITAESAASPAYTE-----HSSFSMDDTSQD-------------------------AKIEPSL-- 1643

  Fly  1595 APATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDD 1635
                 |::....::...||:..|.::::.|:|.:....:|:
 Worm  1644 -----TENQQPTTTATTTTTVPQQQQQQQQQKSSKKKRNDN 1679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	20/106 (19%)
		PTZ00121	<477..651	CDD:173412	42/218 (19%)
		HSA	501..573	CDD:214727	25/95 (26%)
		BRK	650..691	CDD:462196	5/40 (13%)
		PLN03142	739..>1368	CDD:215601	262/986 (27%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/127 (19%)
ssl-1	NP_001255179.1	HSA	231..295	CDD:462194	9/77 (12%)
		PLN03142	372..>851	CDD:215601	191/570 (34%)
		DEXQc_SRCAP	558..780	CDD:350761	109/226 (48%)
		SF2_C_SNF	1183..1312	CDD:350180	59/129 (46%)
		Med15	1978..>2359	CDD:312941