DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and pqn-15

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001367558.1	Gene:	pqn-15 / 180705	WormBaseID:	WBGene00004106	Length:	2171	Species:	Caenorhabditis elegans

Alignment Length:	1838	Identity:	653/1838 - (35%)
Similarity:	883/1838 - (48%)	Gaps:	515/1838 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PANSPMPPPQAPSPM-APPSQ---------------SPAPSPHSPYPHQQ--------------- 39
            |.:.|....|.||.| .||.|               :.:|....|..|||
Worm   271 PPSQPHYIQQGPSSMNTPPQQQMRMQQIQQNNQNMNNGSPHQQQPLQHQQMQQNAPNMNMPPQQQ 335

  Fly    40 -------PGPLQGP---PPPGHPGAYGHPMQHGPPGQGPPGHHMPPHHQGMIFSKGPHMGMQMPP 94
                   |..|||.   |||.|......|::.....|.|....:||.......|:..|..||..|
Worm   336 IRIQQQEPQMLQGQTNGPPPPHQQQQQQPVRVAQVAQQPQNMQIPPRQMTPQQSQSIHGSMQNSP 400

  Fly    95 TGP----NMSP---YQTH--------GMPPNAPTQPCIVSPG-------------------GPPG 125
            ..|    |::|   .|.|        |.|.:....|.:..||                   ....
Worm   401 QNPQMRMNLAPPQQQQQHHQNQPPMQGNPQSDRQMPQMQQPGRQIHPNIKRQPQHQMQQNRSMQQ 465

  Fly   126 GPPPPERSSQENLHALQRAIDSMEEKGLQEDPR-------------YSQLL-------------- 163
            ||..|:....:.::..|...|.|.::.|||.|:             .||::
Worm   466 GPHNPQNIPDQMMNMQQMQQDPMSQQPLQESPQPNLHLQHHQTPPMQSQMMQPVVTDNFEPDNDQ 530

  Fly   164 AMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQ---MQQALQAAQQQPPPGPPIGPPGAP 225
            .:|...:|..:||.|..|:..|    |...:.|..:.|   |||..|...|:.......|||...
Worm   531 TIRINGEHAIINGMQYKLVPQQ----RQQNQQKMPNQQGQPMQQVHQGGHQEEGFQQQHGPPNNQ 591

  Fly   226 G-GPPPGSQHAGQPPVPPQQQQ-----QPPPSAGTPPQCSTPPASNPYGPPVPGQKMQ------- 277
            | ...|..|:....|:..||||     ||..|.......:.....|...||:..|:.|
Worm   592 GQNQQPPMQNQQNIPIQHQQQQQNMMNQPMQSNNNQNMANIQNQQNLQNPPIIQQQQQQQIPPAK 656

  Fly   278 VAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPP----------PPE------PHQ 326
            |||.|.:  :|:..|.|.|    ||||||..........|..|          .|.      ..|
Worm   657 VAPKPRY--RGKKNPAQEP----PPPIQQTNAEDLNNSMSGLPMGAKGERKVMAPSLTTNTFHQQ 715

  Fly   327 HQLPNGGKPLSMGP--------SGGQPLIPSSPMQPQVRGTLPGMPPGSQVP------------- 370
            .|.|||..|.:.||        :||.|     |.|.:|       .||..||
Worm   716 QQAPNGLPPNNAGPMIQQGKNIAGGYP-----PNQNKV-------TPGKNVPKNQQQSRPQQANG 768

  Fly   371 -----------QPGGGPQRQVPPAG---------------------------------------- 384
                       ||....||  |||.
Worm   769 KVQAKSSPDLSQPSTSKQR--PPANKADMTVIRDAIVSHVKGSRKMTPEYIEYVCEELNRLMREL 831

  Fly   385 -----------------------------MP--MPKPNRITTVAKPVGLDPITLLQERENRIAAR 418
                                         :|  :|.|.|.....:.:|.:|:.  :..|:| |||
Worm   832 EKADMKTDRRYISVRKLLALIQEEKLTIIIPPRIPMPARYPPTEESLGDEPVD--ETVEDR-AAR 893

  Fly   419 ISLRMQ--------------------ELQRLPA--------------------TMSEDLRLQAAI 443
            ....||                    ::.|..|                    |..|:.:.:|.|
Worm   894 YDDYMQVLANAYPLNTWDSNFMKIDDDIIRKEALHYRDQDMKNREMYLKENLHTFPEERQTKAKI 958

  Fly   444 ELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERK 508
            |...|.:|:||.:||.:.:..|......:..:|....:|||.:.|:|.:     ....:...|::
Worm   959 EYLGLSLLDFQTELRKKVLATTVLVPPNDFLINPWSIRRTKYEYLQELK-----RHPDRAILEKR 1018

  Fly   509 RRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMA 573
            |:..:..||.::.:|.::.:|||:.|.....::.|::..:..|..:...:|:.:.||.|:::|:.
Worm  1019 RKVTNFHFLQSLTKHAREFKEFHKRNMLNHTKVRKSMQQYITNENKRIAREEMKNEKNRIQKLIQ 1083

  Fly   574 EDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSG 638
            |||||||.::|:|||:||.:||.|||:||.:|..::||.::
Worm  1084 EDEEGYRAMLDEKKDQRLVYLLEQTDDYIKSLCDLLKQQQN------------------------ 1124

  Fly   639 EYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHK 703
                ...||:...                                   .:|..|.|.....|..|
Worm  1125 ----ATAGSLATK-----------------------------------SYIRKEYDGVAEEDKVK 1150

  Fly   704 PKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIM 768
                       ...|||:   ||:|..:..||..:||         ||:.||.:.|::.||..:|
Worm  1151 -----------SILDKAR---NDDDEYENKTKMNIED---------YYTTAHGVREEIKEQHFMM 1192

  Fly   769 VNGT----LKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIV 829
            ..|.    ||.||||||||:|||:|||||||||||||||||||||:.:||||:.||..||:|:||
Worm  1193 GGGNPSLKLKPYQIKGLEWMVSLFNNNLNGILADEMGLGKTIQTIAFITYLMEIKKTSGPFLVIV 1257

  Fly   830 PLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQW 894
            ||||:|||..||:|||..|.:::|||..:.|::.:..:::.||||||||:||||::||:|.|::|
Worm  1258 PLSTVPNWQNEFDKWAANVHLIAYKGPKETRKVFEPIIKSGKFNVLLTTFEYVIREKALLGKLRW 1322

  Fly   895 KYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE 959
            ||||||||||:||.|||||::|||.:....|||:||||||||||||||||||||||||.||||||
Worm  1323 KYMIIDEGHRLKNQHCKLTEMLNTRFQCQRRLLITGTPLQNKLPELWALLNFLLPSIFSSCSTFE 1387

  Fly   960 QWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQR 1024
            ||||||||||||||||.:|||:|||||||||||||||||||||||.:||||:|::::|||||||:
Worm  1388 QWFNAPFATTGEKVELTQEETMLIIRRLHKVLRPFLLRRLKKEVESELPDKMEFVVRCDMSALQK 1452

  Fly  1025 VLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVS 1089
            ||||||| ||:|| ||..     ..|:|:|.||::.|||||||||:|:::||. |.:......:|
Worm  1453 VLYKHMQ-KGLLL-DGKT-----NTGSKSLRNTMIHLRKLCNHPFLFENVEES-CRNFWDARFIS 1509

  Fly  1090 GPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRG 1154
            ..||||||||.|||.||||||:||.||||:|.|||..|||:||:|......||||||:||.::||
Worm  1510 AVDLYRVSGKLELLSRILPKLQATGHRVLMFFQMTSMMTIVEDFLAGGTIQYLRLDGSTKPDERG 1574

  Fly  1155 ELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRV 1219
            .||.||||..|:.|:|:||||||||||||||||||:|||||||||||:|||||||||||:.||||
Worm  1575 ALLDKFNAPNSEYFLFMLSTRAGGLGLNLQTADTVIIFDSDWNPHQDMQAQDRAHRIGQKAEVRV 1639

  Fly  1220 LRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPD 1284
            .||:|.|||||:||||||||||:||||||||.||.:|||:||::.|:.|: :.:||.||:.|||:
Worm  1640 FRLITANSVEEKILAAARYKLNVDEKVIQAGKFDNRSTGAERREILENII-KTENESEEDEEVPN 1703

  Fly  1285 DEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDE 1349
            ||.||.:::|||||.|:|::||.|| .|:|:....:.||:.|.|:|..:.:..||.:......:|
Worm  1704 DEDINDILSRSEEEFELFQKMDQER-FENEQAQKAKPRLVGEDEIPRDILRAADETDYIEKAKEE 1767

  Fly  1350 DTILGR--------GSRQ-RKEVDYT-DSLTEKEWLKAIDDGAEFDEE-------EEE------- 1390
                ||        |||: |:||||: |::::.::|:.:     |||:       |||
Worm  1768 ----GRVPYLEVMPGSRRTRREVDYSADTMSDDKFLEKL-----FDEDDTTSARTEEEPNPAQPG 1823

  Fly  1391 -----------------------------------------DDSKRKRRKRKNRKEESDDDSLIL 1414
                                                     |:.|||.    ||.|...||:.:.
Worm  1824 PSSVSISLESSCDTQKDIKVDDVPAPPLTFKVPRLTIKLGGDEKKRKH----NRSESDSDDNSLK 1884

  Fly  1415 KRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVD--IKKIL 1477
            |.::.:..|...:|:..|                   .|...:::..|..:.:||.::  |:||
Worm  1885 KEKKHRKEDHPKEKEKEK-------------------KKEKEQEKSTDSEKDLKRKIEAPIEKI- 1929

  Fly  1478 QRIE-----DCKYADLNE 1490
             ||:     ..||..:||
Worm  1930 -RIKFSGEPSEKYRKINE 1946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	8/32 (25%)
		Drf_FH1	251..390	CDD:283903	50/264 (19%)
		HSA	501..573	CDD:214727	16/71 (23%)
		BRK	649..693	CDD:197800	1/43 (2%)
		PHA02934	687..>824	CDD:165245	64/140 (46%)
		SNF2_N	776..1071	CDD:278600	211/294 (72%)
		DEXDc	793..932	CDD:238005	87/138 (63%)
		Helicase_C	1097..1212	CDD:278689	84/114 (74%)
		SnAC	1304..1375	CDD:291293	25/80 (31%)
		Bromo_SNF2L2	1425..1530	CDD:99947	15/73 (21%)
pqn-15	NP_001367558.1	Med15	<1..>288	CDD:312941	6/16 (38%)
		Med15	183..>573	CDD:312941	67/305 (22%)
		HSA	1011..1083	CDD:214727	16/71 (23%)
		PLN03142	1062..>1726	CDD:215601	422/758 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	433	1.000	Domainoid score	I292
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920