Protein Alignment brm and chd-1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_491994.2
• Gene: chd-1 / 172432
• WormBaseID: WBGene00010369
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1167
• Identity: 343/1167 - (29%)
• Similarity: 514/1167 - (44%)
• Gaps: 300/1167 - (25%)

  Fly   531 HRNNKAQLARMNKAVMNHH----------------ANAEREQKKEQERIEKERMRRLMAEDEEGY 579
            :.||:...|...|.:.|.:                .|:|..|..|.:..::.:.||.:.
 Worm    79 NNNNRGMDAETRKLLENENYFRRSKRSKRQDDSPSDNSEESQSSEDDWDDRRKPRRTVT------ 137

  Fly   580 RKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGID 644
            :|::.|.| |.::.:..::   :.......:::.||.:...:     ::::.:|..:..
 Worm   138 KKVVKQTK-KAVSVVKRKS---VKGNVNYAEKNSDDDIDDDD-----VLEWDEEPAVPA------ 187

  Fly   645 EGSIVADMRV-------HVVEQCTGKKLT----------GDDAPMLKHLHR-------WLNMHPG 685
            ||..:....|       |.|...||...|          .|..|..|...:       |.::|..
 Worm   188 EGPAILTETVERVIKWRHGVPGATGSATTCYNIADKGDPNDQIPGDKTEQQFFVKWTGWSHLHNT 252

  Fly   686 WD----------------------------W---IDDE------------EDSCGSNDDHKPKVE 707
            |:                            |   .|.|            |:.|   :::| |||
 Worm   253 WESENSLALMNAKGLKKVQNYVKKQKEVEMWKRSADKEYIEFFECEQQMAEELC---EEYK-KVE 313

  Fly   708 E---QPTATEDATDKAQATGNDEDAKDLI-------TKAKVEDDEYRTEEQ--TYYSIAHTIH-- 758
            .   ..|:.:.|.|.:.||      :.||       :....||::....||  .||   |.|.
 Worm   314 RVVAHQTSRDRAADGSMAT------EYLIKWSGLPYSDCTWEDEKMVAPEQIKAYY---HRIENL 369

  Fly   759 ----------------EKVVEQASIM-VNG----TLKEYQIKGLEWLVSLYNNNLNGILADEMGL 802
                            ||.......: .:|    .|::||::||.|:|..:....:.||||||||
 Worm   370 KSPNKNSNVLRKRPKFEKFESMPDFLKTDGESTHKLRDYQLEGLNWMVYAWCKGNSSILADEMGL 434

  Fly   803 GKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQ- 866
            |||||:|||:..|..|..:.||||::|||||:..|..||.:|||.:.:|.|.|....|.:::..
 Worm   435 GKTIQSISLLASLFHRYDLAGPYLVVVPLSTMAAWQKEFAQWAPEMNLVVYMGDVVSRDMIRQYE 499

  Fly   867 -----MRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRL 926
                 .:..|.|.:|||||.::||||.|:.|.|..:::||.||:||....|.:.| |.:...::|
 Worm   500 WFVGGTKKMKINAILTTYEILLKDKAFLSSIDWAALLVDEAHRLKNDESLLYKSL-TQFRFNHKL 563

  Fly   927 LLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVL 991
            |:|||||||.|.||||||:|::|..|.....||...|          |.|.:.    |..|||.|
 Worm   564 LITGTPLQNSLKELWALLHFIMPEKFDCWEEFETAHN----------ESNHKG----ISALHKKL 614

  Fly   992 RPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMN 1056
            .||||||:||:||..||.|.|.|::.||:|.|:..||.:.:|..     .|..|..||.....:|
 Worm   615 EPFLLRRVKKDVEKSLPPKTEQILRVDMTAHQKQFYKWILTKNY-----RELSKGVKGSINGFVN 674

  Fly  1057 TIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFC 1121
            .:::|:|.|||..:.:..:..|.|..|     ....|.:.|||..|||::|.:||...||||:|.
 Worm   675 LVMELKKCCNHASLTRQYDHIYDDAQG-----RLQQLLKSSGKLILLDKLLCRLKDKGHRVLIFS 734

  Fly  1122 QMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTA 1186
            ||...:.|:::||..|:|...||||:.:|:.|.:.|..:||.||..|.|||||||||||:||.||
 Worm   735 QMVMMLDILQEYLQLRRFPSQRLDGSMRADLRKQALDHYNAPGSTDFAFLLSTRAGGLGINLATA 799

  Fly  1187 DTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ--- 1248
            |||:||||||||..||||..|||||||...|.:.||:|..||||.|:..|:.||.:|..|||
 Worm   800 DTVIIFDSDWNPQNDLQAMSRAHRIGQTKTVNIYRLVTKGSVEEEIVERAKRKLVLDHLVIQRMD 864

  Fly  1249 ---AGMFDQKSTGS-----ERQQ------FLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEI 1299
               ..:..:.:|.|     ::|:      |....|.::...||:|.||..|.::
 Worm   865 TTGKTVLSKNATASGSVPFDKQELSAILKFGAVELFKEKEGEEQEPEVDIDRIL----------- 918

  Fly  1300 EIFKRMDAERKKEDEEIHPGRERL---------IDESE-----LPDW--LTKDDD-----EVERF 1343
                 |.||.::.:||:....|.|         |||.:     ..:|  :..::|     |.||.
 Worm   919 -----MGAETREAEEEVMKENELLSSFKYANFAIDEEKDIAAATDEWAAIIPEEDRNRILEEERM 978

  Fly  1344 HYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRK------- 1401
                .|...:....||||:.  ...:.|.      |||   |::|||||:.:|::|:.
 Worm   979 ----KELAEMNLAPRQRKQP--IPQVVED------DDG---DDDEEEDDTGKKKKKKAVGNFTIP 1028

  Fly  1402 ----------------NRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEP 1450
                            ||.||...|:         .|::.|..:|.|::          .:|||.
 Worm  1029 EIKRFIKSFRKFSMPLNRLEEIAQDA---------ELEEHSTDEMKKLV----------ESLSEA 1074

  Fly  1451 FMK----LPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEE 1508
            ..|    ..|.::..|.........||::.. :...|. .:|.::|:...:|....:|...|
 Worm  1075 CKKAADEFDSNEKNGDAGAAESEKKDIERKF-KFHTCD-VNLKQIERSHAELKPLHEILKSE 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	20/135 (15%)
		HSA	501..573	CDD:214727	11/57 (19%)
		BRK	650..691	CDD:462196	13/95 (14%)
		PLN03142	739..>1368	CDD:215601	260/697 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	17/88 (19%)
chd-1	NP_491994.2	CD1_tandem_CHD1-2_like	194..275	CDD:349313	12/80 (15%)
		CD2_tandem	308..363	CDD:349306	15/61 (25%)
		PLN03142	404..1245	CDD:215601	284/808 (35%)
		DUF4208	1298..1367	CDD:464035