Protein Alignment brm and Hel89B

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_321235.5
• Gene: Hel89B / 1281292
• VectorBaseID: AGAMI1_004308
• Length: 2067
• Species: Anopheles gambiae
• Alignment Length: 596
• Identity: 192/596 - (32%)
• Similarity: 298/596 - (50%)
• Gaps: 80/596 - (13%)

  Fly   731 DLITKAKVEDD---EYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNL 792
            |.:.:.|::|.   ||....:|...:          :..:.:|..|:.||..|:.||..|....|
Mosquito  1427 DDLRQRKMKDRRFLEYLFSPKTIPDV----------ELPVKINAELRSYQQSGVNWLWFLNRYKL 1481

  Fly   793 NGILADEMGLGKTIQTISLVT-----YLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPA--VGV 850
            :|||.|:||||||:|.|.::.     ..:||.....|.::|.|.:...:||.|.||:.|:  :..
Mosquito  1482 HGILCDDMGLGKTLQAICILAADHHQRSLDRGCAQLPSIVICPPTLTGHWVYEVEKFLPSRFLRP 1546

  Fly   851 VSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQV 915
            :.|.|.|..|..|:.::..  :|:::.:|:.|.||....:.:.|.|.|:||||.:||...|.::.
Mosquito  1547 LHYVGLPGNREQLRQKLGT--YNLIVASYDIVRKDIEFFSSVNWNYCILDEGHIIKNGRTKSSKA 1609

  Fly   916 LNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAP-FATTGEKVELNEEE 979
            :. ..:|.:||:|:|||:||.:.|||:|.:||:|....:...|...|:.| .|:...|....|:|
Mosquito  1610 IK-QLVANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFSTRFSRPILASRDPKSSPKEQE 1673

  Fly   980 T-ILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYK-----HMQSKGVL-- 1036
            . .|.:..||:.:.||||||:|::|...||.|:...:.|::|.||..||:     |:.|..:.
Mosquito  1674 AGALAMEALHRQVLPFLLRRVKEDVLTDLPPKITQDLLCELSPLQERLYEDFSRMHLHSSDIREC 1738

  Fly  1037 --LTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGK 1099
              ..||...|...|  ...:...:..|:.:||||.:...              .|.|:...:.|:
Mosquito  1739 LENIDGQMAGPANK--KTHVFQALRYLQNVCNHPKLVLS--------------PSHPEYQMIVGE 1787

  Fly  1100 F----ELLDRI-----LPKLK--------ATN-------HRVLLFCQMTQCMTIIEDYLGWRQF- 1139
            |    ..:|.|     ||.||        .||       ||.|:|||:...:.|:|:.|..:..
Mosquito  1788 FTRNGSSMDDIEHSAKLPVLKQLLLDCGIGTNEDVSVNQHRALIFCQLKAMLDIVENDLLKKHLP 1852

  Fly  1140 --GYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDL 1202
              .||||||:.....|..::.|||...| :.|.||:|:.|||||||..||||:..:.||||.:||
Mosquito  1853 AVSYLRLDGSVPPSTRHHIVTKFNGDPS-IDVLLLTTQVGGLGLNLTGADTVIFVEHDWNPMKDL 1916

  Fly  1203 QAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQT 1267
            ||.||||||||:..|.|.||:|..|:||:|:...::||.....|:........:.|::  |.|..
Mosquito  1917 QAMDRAHRIGQKKVVNVYRLITRKSLEEKIMGLQKFKLLTANTVVSDENASMDTMGTD--QLLDL 1979

  Fly  1268 ILHQDDNEEEE 1278
            ....||:.:::
Mosquito  1980 FTLADDSGKQQ 1990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601	190/588 (32%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Hel89B	XP_321235.5	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		DUF3535	715..1242	CDD:463447
		HepA	<1453..1962	CDD:440319	181/528 (34%)