Protein Alignment brm and Mi-2

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_061510532.1
• Gene: Mi-2 / 1280662
• VectorBaseID: AGAMI1_012829
• Length: 2152
• Species: Anopheles gambiae
• Alignment Length: 1279
• Identity: 373/1279 - (29%)
• Similarity: 573/1279 - (44%)
• Gaps: 303/1279 - (23%)

  Fly   579 YRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKE-EEGKRLIQFKKELLMSGEYIG 642
            |.:..|.::..:|...|.:.|.....:.:|  :..:.|:.:.| ||.......|.|.||
Mosquito   617 YTRKNDMEEPPKLEEALDEEDNRYKRIQRM--RETNCQLNETELEEKYYRYGVKPEWLM------ 673

  Fly   643 IDEGSIVADMRVH-VVEQCT---GKKLTGDDAPMLKHLHRWLNMHPGWD---WIDDEEDSCGSND 700
                       || |:...|   |:.|         :|.:|..:  .:|   |.|:|:|..|...
Mosquito   674 -----------VHRVINHRTMRDGRTL---------YLVKWREL--SYDQATWEDEEDDIAGLKM 716

  Fly   701 DHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHT--------- 756
            ..:..::.:...::|.  ....:|....:|....|.:....|...||:|.....:|
Mosquito   717 AIEYYLDLRANCSQDI--GGSGSGGSGSSKKNKKKGRRRLRELEEEERTAGVKRYTPPPEKPTTD 779

  Fly   757 IHEKVVEQASIM--VNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRK 819
            :..|...|...:  ....|..||::|:.||...:.|..:.||||||||||||||.:.:..|....
Mosquito   780 LKRKFEVQPPYLDETGMRLHPYQLEGINWLRYSWANGTDTILADEMGLGKTIQTATFLYSLYKEG 844

  Fly   820 KVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ----------------NQMR 868
            ...||:|:.|||||:.||..|||.|||....::|.|..:.|.:::                :::|
Mosquito   845 HCRGPFLVAVPLSTIINWEREFETWAPDFYCITYVGDKESRAVIRENELSFEEGAVRGGKASRIR 909

  Fly   869 AT--KFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGT 931
            |:  |||||||:||.:..|.|.|..|.|..:::||.||:|::..|..:|||.:.|| |:||||||
Mosquito   910 ASSIKFNVLLTSYELISIDAACLGSIDWSVLVVDEAHRLKSNQSKFFKVLNAYNIA-YKLLLTGT 973

  Fly   932 PLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLL 996
            ||||.|.||:.|||||..|.|...:.|:..|          .::::||.   ::|||::|.|.:|
Mosquito   974 PLQNNLEELFHLLNFLNKSKFNELAEFQNEF----------ADISKEEQ---VKRLHEMLGPHML 1025

  Fly   997 RRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK-GKHGKGGAKALMNTIVQ 1060
            ||||.:|...:|.|.|:|::.::|.||:..||:      :||...|. ...|.|||.:|:|.::.
Mosquito  1026 RRLKADVLKNMPTKSEFIVRVELSPLQKKYYKY------ILTRNYEALNPKGGGGACSLINIMMD 1084

  Fly  1061 LRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQ 1125
            |:|.||||::|....|:.....||:..:.  .|.:.:||..||:::|..||:..||||:|.|||:
Mosquito  1085 LKKCCNHPYLFAAAAEEAQLGPGGNYELQ--SLTKAAGKLVLLEKMLRLLKSQGHRVLIFSQMTK 1147

  Fly  1126 CMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVV 1190
            .:.|:||:|....:.|.|:||......|.|.:.:|||.|:..|.|||||||||||:||.|||||:
Mosquito  1148 MLDILEDFLEGLGYKYERIDGGITGSIRQEAIDRFNAPGAPQFCFLLSTRAGGLGINLATADTVI 1212

  Fly  1191 IFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQK 1255
            |:|||||||.|:||..|||||||.|:|.:.|.:|.||||||:...|:.|:.:...|::.|| ..|
Mosquito  1213 IYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGM-GGK 1276

  Fly  1256 STGSERQQFLQTILH-------QDDNEEEEENEVPDDEMINMMIARSEEEIE-----------IF 1302
            .|...:|: |..||.       ::|.::||.... ||:.:..::.||.:.:|           .|
Mosquito  1277 GTNFTKQE-LDDILRFGTEELFKEDGKDEEAIHY-DDKAVAELLDRSNKGVEEKENWANEYLSSF 1339

  Fly  1303 KRMDAERKKEDEEIHPGRERLIDESELPD---WLTKDDDEVERFHY-QYDED--TILGRGSRQRK 1361
            | :.:...|||.|.....|.:..|:|..|   |:     ::.|.|| |:.||  ..||:|.|.||
Mosquito  1340 K-VASYSTKEDVEEEAETEVIKQEAENSDPAYWV-----KLLRHHYEQHQEDLSRTLGKGKRVRK 1398

  Fly  1362 EVDYTDS--------LTEKEWLKAIDD-------GAEFDEEEEEDDSK----RKRRKRKNRKEES 1407
            :|:|||.        ..:..|.:.:.|       ||. ||:.:|||.:    |:.|:|..|||..
Mosquito  1399 QVNYTDGGVIQADPVKEDSTWQENVSDYNNSDYSGAS-DEDRDEDDEESELGRRSRRRIERKEAE 1462

  Fly  1408 DDDSLI--LKRRRRQNLDKR--SKKQMHKIMSAVIK---------HNQ----DGRTLSEPFMK-- 1453
            .|:..:  |..|...|::..  :.:|....::|:::         |:|    |.|..||...|
Mosquito  1463 RDNRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFHSQWLVRDLRGKSERIFKAY 1527

  Fly  1454 ----------------------LP----SRQRLPDYYEIIKRPVDIKKILQRIEDCK-YADLNEL 1491
                                  :|    |||.:.....::..   |:|.:|..|... |..:.||
Mosquito  1528 VSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSL---IRKKVQEFEHINGYYSMPEL 1589

  Fly  1492 EKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGAR---QRITAAADAAAVAAGD---------- 1543
            .|   :.|:..:|           ::|.... |||.   :..:..|.|||.|:|:
Mosquito  1590 IK---RPCEPVKI-----------AVAAPAA-VGAAPGGEGTSGTAGAAAPASGETSKSATTSTS 1639

  Fly  1544 -------------------------NTGEAHGNGGSDNSDND---------------------DD 1562
                                     .:||...:||......|                     .:
Mosquito  1640 ATPATSAAPSPAPNASASGDKEEEQQSGEKATDGGDKEKPTDGGSGTTPAEEGEKAAEVKKEVKE 1704

  Fly  1563 DGGDDGSD-------------------DEEIAT----------TSAAAVKMKLKLNKSLASAPAT 1598
            :|.||.:|                   ||.:.|          ....|:.:|....:..|.||..
Mosquito  1705 EGADDATDKKPTGDNKKDESSGEVTAKDEPMDTDGEKKDDKQPAGEEAIDLKSVKTEEDAVAPKK 1769

  Fly  1599 PTQSSSNVS------SGAATTSKKQTRRKRSQKKYTISDDDDDD 1636
            ........|      .|||.:|.::.::...:.|....::||||
Mosquito  1770 EAGDEKEKSEEKKPADGAAKSSAEEAKKAPVEAKKEAEEEDDDD 1813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	14/72 (19%)
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196	10/47 (21%)
		PLN03142	739..>1368	CDD:215601	261/682 (38%)
		Bromo_SNF2L2	1425..1530	CDD:99947	27/151 (18%)
Mi-2	XP_061510532.1	None