Protein Alignment brm and kis

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_061512916.1
• Gene: kis / 1277495
• VectorBaseID: AGAMI1_002666
• Length: 6890
• Species: Anopheles gambiae
• Alignment Length: 1827
• Identity: 447/1827 - (24%)
• Similarity: 714/1827 - (39%)
• Gaps: 430/1827 - (23%)

  Fly    12 PPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP--GAYGHPMQHGPPGQGPPGHHMP 74
            |.|:.|:    .|:|...|..|..|..:.|..........|  |......:.|.......|....
Mosquito  1950 PEPETPT----KSKSKKSSKKSKEPGSEGGSSSSSRNRSRPSGGGSSSSRRSGGSKSSGGGSKSR 2010

  Fly    75 PHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPP------PERS 133
            .....||.::....|..:..|                           ||..|||      .:|.
Mosquito  2011 SRRSRMIVTESDGEGDDLLST---------------------------PPPSPPPDMEADSSKRR 2048

  Fly   134 SQENLHALQRAIDSM-----EEKGLQEDPRYSQLLAMRATSKHQHLNG---NQVNLLRTQITAYR 190
            |..|....:...|.|     :|.|:...       |...:.|.:..:|   .:..|..|::.
Mosquito  2049 SARNTQRKKYVDDVMLRFSDDESGMMSP-------APSGSRKDRRSDGGSDRKEGLAPTEVA--- 2103

  Fly   191 LLARNKPISMQMQQALQAAQQQPPPGPPIGPPG-APGGPPPGSQHAG-QPPVPPQQQQQPPPSA- 252
             ||..:            |......|...|..| |......||:.|| :..|...:..:..|.|
Mosquito  2104 -LAGGE------------AGAVAADGSVAGVAGEASSVVGTGSEQAGDENKVSTSEGAKAAPEAV 2155

  Fly   253 -----GTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQG-QPLPPQPPQVGGPPPIQQQQP-- 309
                 |.|...|:.|.:|........:...|......:::| :.|.|.||    |||.:::.|
Mosquito  2156 ELGPDGKPIDDSSKPNANYVYVNTSEEDSMVVQYVLAVRKGRRELKPDPP----PPPPKEKTPEP 2216

  Fly   310 ---PQQQQQQSQPPPPEPHQHQLPNG-------------GKPL------------------SMGP 340
               ..::..:|:|...|.....:.:|             ||.|                  :.|.
Mosquito  2217 AEGSAEEAVKSEPKEGEEKAAAVGDGSETTAAEATVKEEGKELKEVSEDGEDKKKEAEDVDASGE 2281

  Fly   341 SGGQPLIPSS-----PMQ--PQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAK 398
            ...:...|::     ||:  .:.:.|...:.|.|.....|..|:::.........:....|...:
Mosquito  2282 VADKEAAPTTTATDVPMETSEETKSTEEKISPESDTANTGAEPEQKPSAEDASKAEEKMETDEQE 2346

  Fly   399 PVGL--DPITLLQERENRIAARISLRMQELQ-RLP----ATMSEDLRLQAAIELRALRVLNFQRQ 456
            .||:  :..|..:|:|.......|..:.:.| :.|    ||..|.:...|            :..
Mosquito  2347 SVGVAAEKDTPAEEKEGEEKKEASADVDQQQVKEPVADAATAKESMETDA------------EEP 2399

  Fly   457 LRMEFVQCTRRDTTL-----ETALNIKLYKRTKRQGLREARATEK----LEKQQKLEAERKRRQK 512
            .:.|.|.....|.|.     |.|:..|..:...:.   ||.|||.    :||.: :|.|.:..:|
Mosquito  2400 PKTESVNTAAEDKTAEQPNGEPAVEEKPARVADKP---EAEATEATADGVEKME-VEGESEGTEK 2460

  Fly   513 HLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEE 577
            ..|        |.|.       .|.:.:...|     ...|...:|..|.::||.......|
Mosquito  2461 KPE--------GDDA-------AADVVKKESA-----EGGESTDEKSSEAVKKEEGESASTE--- 2502

  Fly   578 GYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQH-----KDDQMKKKEEEGKRLIQF-KKELLM 636
                 .|:||.:.:..   ..:||..........|     :|:.:|..:..|.::.:| .|:...
Mosquito  2503 -----TDEKKPEPVYI---DVEEYFVKYRNFSYLHCEWRTEDELLKGDKRVGNKIKRFLMKQQQQ 2559

  Fly   637 SGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKH-LHRWLNM---HPGWDWIDDEEDSCG 697
            ...:..:||.....|. |.|.......:|..|:...:|| |.:|.::   ...|: ::|:.|...
Mosquito  2560 LNIFESLDEEPFNPDF-VEVDRVLDVSELVDDEGKTVKHYLVKWKSLPYEDSTWE-LEDDVDQLK 2622

  Fly   698 SNDDHK-----PKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTI 757
            ....:|     ||.|.:                        ||.:...|:::.
Mosquito  2623 IEQYYKFNKIPPKSEWK------------------------TKKRPHPDQWKA------------ 2651

  Fly   758 HEKVVEQASIMVNGTLKEYQIKGLEWL-VSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKV 821
               :.|..:......|:.||::||.|| .|.|..| |.|||||||||||||:::.|..:.: ..:
Mosquito  2652 ---LPESPTFKGGNKLRPYQLEGLNWLRYSWYKGN-NCILADEMGLGKTIQSLTFVNSVYE-YGI 2711

  Fly   822 MGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQ------------MRATKFNV 874
            .||:|:|.||||:|||..|||.|. .:.|:.|.||...|:::|:.            ...|||||
Mosquito  2712 RGPFLVIAPLSTIPNWQREFEGWT-EMNVIVYHGSATSRQMIQDYEVHYRTETGKLIRDITKFNV 2775

  Fly   875 LLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPE 939
            |:||:|.::.|...|....|:..:|||.||:||.:|||.:.|....: .:|:||:||||||.:.|
Mosquito  2776 LITTFEMIVTDYQDLKNFTWRACVIDEAHRLKNRNCKLLEGLRQLNL-EHRVLLSGTPLQNNVNE 2839

  Fly   940 LWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVE 1004
            |::|||||.||.|.....|.:.|.:          |..|..:|   :|..:|:|.:|||||.:||
Mosquito  2840 LFSLLNFLEPSQFACSEEFLREFGS----------LKTESEVL---KLQALLKPMMLRRLKDDVE 2891

  Fly  1005 HQLPDKVEYIIKCDMSALQRVLYKHM--QSKGVLLTDGSEKGKHGKGGAKA----LMNTIVQLRK 1063
            ..|..|.|.|::.:::.:|:..|:.:  |:...|:          ||...|    ||||:::|||
Mosquito  2892 KSLAPKEETIVEVELTNIQKKYYRGILEQNFSFLM----------KGTTSANIPNLMNTMMELRK 2946

  Fly  1064 LCNHPFMFQHIEEK-YCDHTGGHG----------VVSGPDLYRVSGKFELLDRILPKLKATNHRV 1117
            .|.||::....|:: ..|:...||          :||       |||..|:|::||||:|..|||
Mosquito  2947 CCIHPYLLNGAEDQIQYDYRQQHGEDAESYYKNLIVS-------SGKMVLIDKLLPKLRANGHRV 3004

  Fly  1118 LLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLN 1182
            |:|.||.:|:.|:||||.::::.:.|:||..:...|...:.:::...||.|||||.|:|||||:|
Mosquito  3005 LIFSQMVRCLDILEDYLMYKKYPFERIDGRIRGNLRQAAIDRYSKPDSDRFVFLLCTKAGGLGIN 3069

  Fly  1183 LQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVI 1247
            |..||||:|:||||||..|||||.|.|||||:..|::.||:..|:.|..:...|..||.:|:.|:
Mosquito  3070 LTAADTVIIYDSDWNPQNDLQAQARCHRIGQQKMVKIYRLLCRNTYEREMFDKASLKLGLDKAVL 3134

  Fly  1248 QAGMFDQKSTGSERQ---QFLQTILHQ-------DDNEEEEENEVPDDEMI---NMMIARSEEEI 1299
            |:....|...|::||   :.::.:|.:       ||:..::..|...|.::   ..:|....|:.
Mosquito  3135 QSMNTGQNKDGTQRQLSKKEIEDLLKKGAYGAVMDDDAGDKFCEEDIDSILLRRTQVITMESEKG 3199

  Fly  1300 EIFKRMDAERKKEDEEIHPGRERLIDESELPD----WLTKDDDEVERFHYQYDEDTILGRGSR-- 1358
            ..|.:..........:|:      ||:   ||    |..|.:.:.........||.::....|
Mosquito  3200 STFSKASFAASANRSDIN------IDD---PDFWNKWAKKAEIDPTACEKDETEDLVIAEPRRRT 3255

  Fly  1359 QRKEVDYTDSLTEKEWLKAIDD---GAEFDEEEE-----EDDSKRKR--RKRKNRKEESDDDSLI 1413
            |.|...:.|.:.:      |.|   |.:..:.||     :..|||.|  ::||..:::...|..:
Mosquito  3256 QIKRYGHDDGVMD------ISDESSGEQGSDGEEGGIGLKTRSKRTRGAKERKKLQQQMQHDDYV 3314

  Fly  1414 LKRRRRQNL-----DKRS-----KKQMHKIMSAVIKHNQDGRT--LSEPFMKLPSRQRLPDYYEI 1466
              .|.|:.|     |:.|     :.:..|:...::.|.....|  |.:...|...|:
Mosquito  3315 --PRDRETLAVLGADEVSYGNWARSECFKVEKGLLSHGWARWTEILEQGQFKRGWRE-------- 3369

  Fly  1467 IKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRIT 1531
                       |.:|||        .:..:..|......:|:......|.|...:   |..||..
Mosquito  3370 -----------QDVEDC--------ARVILLYCLERYQGDEKIKNFIWDLITPNE---GGEQREI 3412

  Fly  1532 AAADAA---AVAAGDNTGEAHGNGG----------SDNSDNDDDDGGDDGSD---DEEIATTSAA 1580
            |...:.   .|..|.|   |.|...          |.||.....:||..||.   ....:||.|.
Mosquito  3413 ARNHSGLHNLVPRGRN---AKGRKSTSTCTTPKRDSSNSAATGSNGGGGGSPVIAQPAGSTTPAP 3474

  Fly  1581 AVKMKLKLNKSLASAPATPTQSSSNVSSGA----ATTSKKQTRRKRSQKKYTISDDDDDDMDXLP 1641
            ........|:. ||:.::.|::..:..||:    .||...........:||        |.:.|
Mosquito  3475 QCSGTADANED-ASSNSSGTKAEKSAKSGSDTGGTTTPVSDPHHWSKDEKY--------DTETL- 3529

  Fly  1642 LGVIFKR 1648
            |.:.:|:
Mosquito  3530 LDINYKK 3536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	5/31 (16%)
		Pro-rich	<247..401	CDD:464580	34/203 (17%)
		PTZ00121	<477..651	CDD:173412	35/183 (19%)
		HSA	501..573	CDD:214727	13/71 (18%)
		BRK	650..691	CDD:462196	10/44 (23%)
		PLN03142	739..>1368	CDD:215601	231/677 (34%)
		Bromo_SNF2L2	1425..1530	CDD:99947	17/111 (15%)
kis	XP_061512916.1	None