DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brm and Chd1

DIOPT Version :10

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_031716.2 Gene:Chd1 / 12648 MGIID:88393 Length:1711 Species:Mus musculus


Alignment Length:1345 Identity:372/1345 - (27%)
Similarity:591/1345 - (43%) Gaps:327/1345 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   509 RRQKH------LEFLAAVLQHGKDLREFHRNNK-------AQLARMNKAVMNHHANAEREQKKEQ 560
            :|:||      :....:..|.|.|.......:|       :.....||.......|  |.:.|..
Mouse   139 KRKKHNDEDWQMSGSGSPSQSGSDSESEEERDKSSCDGTESDYEPKNKVRSRKPQN--RSKSKNG 201

  Fly   561 ERIEKERMRRLMA---EDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEE 622
            ::|..::.|::.:   ||:|.|..  |::..:|.|             |..|...:|::||...:
Mouse   202 KKILGQKKRQIDSSEDEDDEDYDN--DKRSSRRQA-------------TVNVSYKEDEEMKTDSD 251

  Fly   623 E-----GKRLIQFKKELLMSGEYIGID-----EGSIVADMRVHVVEQCTG--------KKLTGDD 669
            :     |:.:.|.:.|...:.|.: :|     :|:..|...::.|| ..|        .|..|| 
Mouse   252 DLLEVCGEDVPQPEDEEFETIERV-MDCRVGRKGATGATTTIYAVE-ADGDPNAGFERNKEPGD- 313

  Fly   670 APMLKHLHRWLNMHPGWDWI----DDEEDSCGSN-------DDHKPKVEE--------------- 708
               :::|.:|    .||..|    :.||.....|       |::|.|.:|               
Mouse   314 ---IQYLIKW----KGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEY 371

  Fly   709 ---QPTATEDATDKAQ------ATGNDEDAKDL-----------ITKAKVED------------D 741
               |...|:|...:.|      |..|.:.|..|           .::...||            |
Mouse   372 YNCQQELTDDLHKQYQIVERIIAHSNQKSAAGLPDYYCKWQGLPYSECSWEDGALISKKFQTCID 436

  Fly   742 EYRTEEQ---TYYSIAHTIHEK----VVEQASIMVNG----TLKEYQIKGLEWLVSLYNNNLNGI 795
            ||.:..|   |.:.....:.::    .:::....:.|    .|::||:.||.||...:....:.|
Mouse   437 EYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCI 501

  Fly   796 LADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR 860
            |||||||||||||||.:.||....::.||:|::||||||.:|..|.:.||..:..|.|.|....|
Mouse   502 LADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSR 566

  Fly   861 RLLQN------QMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTH 919
            .:::.      |.:..|||:||||||.::||||.|..:.|.::.:||.||:||....|.:.| ..
Mouse   567 NMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTL-ID 630

  Fly   920 YIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILII 984
            :.:.:|||:|||||||.|.|||:||:|::|..|.|...||:       ..|:..|..       .
Mouse   631 FKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEE-------EHGKGREYG-------Y 681

  Fly   985 RRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGV-LLTDGSEKGKHGK 1048
            ..|||.|.||||||:||:||..||.|||.|::.:|||||:..||.:.::.. .|:.||      |
Mouse   682 ASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGS------K 740

  Fly  1049 GGAKALMNTIVQLRKLCNHPFMFQ-------HIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRI 1106
            |.....:|.:::|:|.|||.::.:       :.:::...|           |.|.|||..|||::
Mouse   741 GSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQH-----------LIRSSGKLILLDKL 794

  Fly  1107 LPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFL 1171
            |.:|:...:|||:|.||.:.:.|:.:||.:|||.:.||||:.|.|.|.:.|..|||:||:.|.||
Mouse   795 LIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFL 859

  Fly  1172 LSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAA 1236
            |||||||||:||.:|||||||||||||..|||||.|||||||:.:|.:.||:|..||||.||..|
Mouse   860 LSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERA 924

  Fly  1237 RYKLNMDEKVIQ-----------AGMFDQKSTGSERQQF-------LQTILHQDDNEEEEENEVP 1283
            :.|:.:|..|||           .|.....||...:::.       .:.:..:.:.||:|..|:.
Mouse   925 KKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQEPQEMD 989

  Fly  1284 DDEMINMMIARSEE--------------EIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLT 1334
            .||::........|              ::..|..||    ::|.|:.|.|.....|..:|:...
Mouse   990 IDEILKRAETHENEPGPLSVGDELLSQFKVANFSNMD----EDDIELEPERNSKNWEEIIPEEQR 1050

  Fly  1335 KDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRK 1399
            :..:|.|| ..:.:|..:|.|.....|::.:              :|:|            .||.
Mouse  1051 RRLEEEER-QKELEEIYMLPRMRNCAKQISF--------------NGSE------------GRRS 1088

  Fly  1400 RKNRKEESDDDSLILKRRR-----------RQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMK 1453
            |..|...||.|| |.:|:|           |:|:...|..::.:.:.:..|       ...|..:
Mouse  1089 RSRRYSGSDSDS-ISERKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK-------FGGPLER 1145

  Fly  1454 LPSRQRLPDYYEIIKRPVDIKKILQRIED-CKYA-------------DLNELEKDFMQLCQNAQI 1504
            |.:..|  |...:.|...|::::.:.:.: |..|             .|.:::....:: ...|:
Mouse  1146 LDAIAR--DAELVDKSETDLRRLGELVHNGCVKALKDSSSGTERAGGRLGKVKGPTFRI-SGVQV 1207

  Fly  1505 YNEEASLIYLDS-IALQKVFVG---ARQRITAAADAAAVAAGDNTGE-----------AHGNGGS 1554
             |.:..:.:.|. |.|.|....   .|::.|......|.....:.|:           .:|.|..
Mouse  1208 -NAKLVIAHEDELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSW 1271

  Fly  1555 DNSDNDDD---------DGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGA 1610
            :....|.|         |..|.....:::.|.:...:|:   |::.||...|...       .||
Mouse  1272 EMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKL---LSRDLAKREAQRL-------CGA 1326

  Fly  1611 ATTSKKQTRRKRSQKKYTI-----------------SDDDDDDMD 1638
            ..:.:::||.|:|:...:|                 ||:|||.::
Mouse  1327 GGSKRRKTRAKKSKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLN 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 173..202 CDD:462622
Pro-rich <247..401 CDD:464580
PTZ00121 <477..651 CDD:173412 32/167 (19%)
HSA 501..573 CDD:214727 14/76 (18%)
BRK 650..691 CDD:462196 12/52 (23%)
PLN03142 739..>1368 CDD:215601 253/697 (36%)
Bromo_SNF2L2 1425..1530 CDD:99947 18/122 (15%)
Chd1NP_031716.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..250 26/127 (20%)
CD1_tandem_CHD1-2_like 268..352 CDD:349313 19/93 (20%)
CD2_tandem_CHD1-2_like 385..441 CDD:349308 10/55 (18%)
DEAD-like_helicase_N 458..695 CDD:475120 99/251 (39%)
PLN03142 462..>998 CDD:215601 229/567 (40%)
DEAH box 612..615 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1119 13/67 (19%)
CDH1_2_SANT_HL1 1122..1208 CDD:477096 12/96 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1322..1407 12/57 (21%)
DUF4208 1408..1498 CDD:464035
CHD1 helical C-terminal domain (CHCT). /evidence=ECO:0000250|UniProtKB:O14646 1409..1511
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1503..1588
PHA03420 1591..>1691 CDD:177648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1657
3 X 5 AA repeats of H-S-D-H-R 1629..1645
HisXaaSer_A3 <1632..1659 CDD:439608
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1670..1711
Blue background indicates that the domain is not in the aligned region.

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