Protein Alignment brm and CHD3

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_005256484.1
• Gene: CHD3 / 1107
• HGNCID: 1918
• Length: 2115
• Species: Homo sapiens
• Alignment Length: 1839
• Identity: 470/1839 - (25%)
• Similarity: 720/1839 - (39%)
• Gaps: 479/1839 - (26%)

  Fly     3 SPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGH------PGAYG-HPMQ 60
            || |.....|||..|.|..||     |.|              ||||..      |.|.| ...:
Human    66 SP-PGCHLFPPPPPPPPPLPP-----PPP--------------PPPPDKDDIRLLPSALGVKKRK 110

  Fly    61 HGPPGQ-----GPP------------GHHMPPHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMP 108
            .||..|     |.|            |.....:.: ...|.|...|     |||.....:.|...
Human   111 RGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYRE-KSESGGSEYG-----TGPGRKRRRKHREK 169

  Fly   109 PNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQED-------PRYSQLLAMR 166
            ....|:.  ...|...||....|:.|...| .|...::.:|....:||       ..:||.:...
Human   170 KEKKTKR--RKKGEGDGGQKQVEQKSSATL-LLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPL 231

  Fly   167 ATSKHQHLNGNQVNLLRTQITA-YRLLARNKP-------ISMQMQQALQAAQQQPPPGPPIGPPG 223
            ...|:..:   .::.:.|.:.| :|..:.|.|       ::.....|..|..:|.........|.
Human   232 IAKKNPKI---PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPI 293

  Fly   224 APGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNP------YGPPVP-------GQK 275
            ||.|||      ..|| ||....||||..    :..|.....|      ..|.||       |:|
Human   294 APSGPP------ALPP-PPAADIQPPPIR----RAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKK 347

  Fly   276 MQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNG------GK 334
            |            .||..:...:||    ::::......|..:.|.||..:..|.:|      |:
Human   348 M------------APLKIKLGLLGG----KRKKGGSYVFQSDEGPEPEAEESDLDSGSVHSASGR 396

  Fly   335 P--------LSMGPSG-------GQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAG 384
            |        |..|..|       |.|.:..   :.:|.|.........:|.|.||
Human   397 PDGPVRTKKLKRGRPGRKKKKVLGCPAVAG---EEEVDGYETDHQDYCEVCQQGG---------- 448

  Fly   385 MPMPKPNRITTVAKP-----VGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIE 444
                  ..|.....|     |.|||                    ||.|.|
Human   449 ------EIILCDTCPRAYHLVCLDP--------------------ELDRAP-------------- 473

  Fly   445 LRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLR-EAR-ATEKLEKQQKLEAER 507
                       :.:.....|                   :::|:: ||: ..|:.|::.:.|.|:
Human   474 -----------EGKWSCPHC-------------------EKEGVQWEAKEEEEEYEEEGEEEGEK 508

  Fly   508 KRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHH-----------ANAEREQKKEQE 561
            :....|:|:.......|            :|...:..:.::|           .|.|....:...
Human   509 EEEDDHMEYCRVCKDGG------------ELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTC 561

  Fly   562 RIEKERMRRLM-------------AEDEEGY------RKLIDQKKDKRLAFL---------LSQT 598
            .:.|.|:::::             .:..:|.      |.|  |.:.:|..|:         .|..
Human   562 PVLKGRVQKILHWRWGEPPVAVPAPQQADGNPDVPPPRPL--QGRSEREFFVKWVGLSYWHCSWA 624

  Fly   599 DEYISNLTQMVK----QHKDDQMK-------KKEEEGKRLIQFKKELLMSGEYIGIDE-----GS 647
            .|....:..:|.    |.|:|..:       ..|::||.    .|..:....|..::|     |.
Human   625 KELQLEIFHLVMYRNYQRKNDMDEPPPLDYGSGEDDGKS----DKRKVKDPHYAEMEEKYYRFGI 685

  Fly   648 IVADMRVH-VVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPK------ 705
            ....|.|| ::.....||  |:    ..:|.:|.::.......:::|.:....::||..
Human   686 KPEWMTVHRIINHSVDKK--GN----YHYLVKWRDLPYDQSTWEEDEMNIPEYEEHKQSYWRHRE 744

  Fly   706 --VEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIM 768
              :.|.|........|.:....|..     ..:...|...:.|.|..:..|
Human   745 LIMGEDPAQPRKYKKKKKELQGDGP-----PSSPTNDPTVKYETQPRFITA-------------- 790

  Fly   769 VNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLST 833
            ..|||..||::||.||...:....:.|||||||||||||||..:..|.......||:|:..||||
Human   791 TGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLST 855

  Fly   834 LPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMRA------------TKFNVLLTT 878
            :.||..||:.|||...||:|.|....|.:::        |.::.            .||:||||:
Human   856 IINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTS 920

  Fly   879 YEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWAL 943
            ||.:..|:|.|..|:|..:::||.||:||:..|..:|||.:.| .::||||||||||.|.||:.|
Human   921 YELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKI-DHKLLLTGTPLQNNLEELFHL 984

  Fly   944 LNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLP 1008
            ||||.|..|.:...|.:.|          .::::|:.   |::||.:|.|.:|||||.:|...:|
Human   985 LNFLTPERFNNLEGFLEEF----------ADISKEDQ---IKKLHDLLGPHMLRRLKADVFKNMP 1036

  Fly  1009 DKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK-GKHGKGGAKALMNTIVQLRKLCNHPFMF- 1071
            .|.|.|::.::|.:|:..||:      :||...|. ...|.|...:|:|.::.|:|.||||::|
Human  1037 AKTELIVRVELSPMQKKYYKY------ILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFP 1095

  Fly  1072 -QHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLG 1135
             ..:|.....    .|...|..|.:.|||..||.::|.|||...||||:|.|||:.:.::||:|.
Human  1096 VAAMESPKLP----SGAYEGGALIKSSGKLMLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLD 1156

  Fly  1136 WRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQ 1200
            :..:.|.|:||......|.|.:.:|||.|:..|.|||||||||||:||.|||||:|||||||||.
Human  1157 YEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHN 1221

  Fly  1201 DLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFL 1265
            |:||..|||||||.|:|.:.|.:|..||||||...|:.|:.:...|::.|:  ....||..:|.|
Human  1222 DIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGL--GSKAGSMSKQEL 1284

  Fly  1266 QTI-------LHQDDNE---EEEENEV--PDDEMINMMIARSE------------EEIEIFKRMD 1306
            ..|       |.:|:||   :||::.|  .|:|.|..::.|::            |.:..||...
Human  1285 DDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQ 1349

  Fly  1307 AERKKED--EEIHPGRERLIDESEL-PDWLTKDDDEVERFHYQYDEDTI---LGRGSRQRKEVDY 1365
            ...::||  |||.  ||.:..|..: ||:..|    :.|.||:..::.:   ||:|.|.||:|:|
Human  1350 YVVREEDKIEEIE--REIIKQEENVDPDYWEK----LLRHHYEQQQEDLARNLGKGKRVRKQVNY 1408

  Fly  1366 TDSLTEKEWLKAIDDGAEF---DEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSK 1427
            .|:..|.:     |:.:|:   .|||:||..:|...:|::            ||:.|...||...
Human  1409 NDAAQEDQ-----DNQSEYSVGSEEEDEDFDERPEGRRQS------------KRQLRNEKDKPLP 1456

  Fly  1428 KQMHKIMS--AVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNE 1490
            ..:.::..  .|:..|...|   :.|:....|..:|        |.|.......:.|.:    .:
Human  1457 PLLARVGGNIEVLGFNTRQR---KAFLNAVMRWGMP--------PQDAFTTQWLVRDLR----GK 1506

  Fly  1491 LEKDF--------MQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGE 1547
            .||:|        ..||:.    ..:.|..:.|.:..:.:   :||::.......::........
Human  1507 TEKEFKAYVSLFMRHLCEP----GADGSETFADGVPREGL---SRQQVLTRIGVMSLVKKKVQEF 1564

  Fly  1548 AHGNGGSDNSDNDDDDGGDD------GSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNV 1606
            .|.||.....:...|...|.      .|..:...||..|:.     .|....|.||||..|..
Human  1565 EHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASA-----TNSPCTSKPATPAPSEK-- 1622

  Fly  1607 SSGAATTSKKQTRRKRSQK 1625
            ..|..|..:|:....:.:|
Human  1623 GEGIRTPLEKEEAENQEEK 1641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	5/36 (14%)
		Pro-rich	<247..401	CDD:464580	37/192 (19%)
		PTZ00121	<477..651	CDD:173412	35/230 (15%)
		HSA	501..573	CDD:214727	11/95 (12%)
		BRK	650..691	CDD:462196	8/41 (20%)
		PLN03142	739..>1368	CDD:215601	256/681 (38%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/114 (16%)
CHD3	XP_005256484.1	CHDNT	207..260	CDD:462357	10/55 (18%)
		PHD1_CHD_II	440..482	CDD:277006	14/102 (14%)
		PHD2_CHD_II	517..559	CDD:277007	5/53 (9%)
		CD1_tandem_CHD3-4_like	564..642	CDD:349314	11/79 (14%)
		CD2_tandem_CHD3-4_like	687..741	CDD:349309	11/59 (19%)
		PLN03142	778..>1332	CDD:215601	230/593 (39%)
		DEXHc_CHD3	795..1026	CDD:350813	96/244 (39%)
		DUF1087	<1373..1416	CDD:461922	16/46 (35%)
		CHDII_SANT-like	1437..1576	CDD:461920	27/172 (16%)
		PHA03418	1578..>1727	CDD:177646	17/71 (24%)
		CHDCT2	1797..1923	CDD:462358