DRSC/TRiP Functional Genomics Resources

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Protein Alignment brm and CHD1

DIOPT Version :10

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_001351042.1 Gene:CHD1 / 1105 HGNCID:1915 Length:1798 Species:Homo sapiens


Alignment Length:1380 Identity:369/1380 - (26%)
Similarity:606/1380 - (43%) Gaps:340/1380 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 YKRTKRQGLREARATEKLEKQQKLEAERKRRQK---HLEFLAAVLQHGKDLREFHRNNKAQLARM 541
            ::.:...|..|..::.:.......|.:||:.:.   .:....:..|.|.|........|:.   .
Human   114 HQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSS---C 175

  Fly   542 NKAVMNHHANAEREQKKEQERIEKERMRRLMA------------EDEEGYRKLIDQKKDKRLAFL 594
            ::...::....:.:.:|.|.|.:.:..::::.            :|||.|..  |::..:|.|  
Human   176 DETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDN--DKRSSRRQA-- 236

  Fly   595 LSQTDEYISNLTQMVKQHKDDQMKKKEEE-----GKRLIQFKKELLMSGEYIGID---------E 645
                       |..|...:|::||...::     |:.:.|.::|     |:..|:         :
Human   237 -----------TVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEE-----EFETIERFMDCRIGRK 285

  Fly   646 GSIVADMRVHVVEQCTGKKLTG----DDAPMLKHLHRWLNMHPGWDWI----DDEEDSCGSN--- 699
            |:..|...::.|| ..|....|    .:...:::|.:|    .||..|    :.||.....|   
Human   286 GATGATTTIYAVE-ADGDPNAGFEKNKEPGEIQYLIKW----KGWSHIHNTWETEETLKQQNVRG 345

  Fly   700 ----DDHKPKVEE------------------QPTATED--------------ATDKAQATGND-- 726
                |::|.|.:|                  |...|:|              :..|:.|...|  
Human   346 MKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYY 410

  Fly   727 -------------EDAKDLITKAKVEDDEYRTEEQ---TYYSIAHTIHEK----VVEQASIMVNG 771
                         ||...:..|.:...|||.:..|   |.:.....:.::    .:::....:.|
Human   411 CKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGG 475

  Fly   772 ----TLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLS 832
                .|::||:.||.||...:....:.||||||||||||||||.:.||....::.||:|::||||
Human   476 HEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS 540

  Fly   833 TLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ------NQMRATKFNVLLTTYEYVIKDKAVLAK 891
            ||.:|..|.:.||..:..|.|.|....|.:::      :|.:..|||:||||||.::||||.|..
Human   541 TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGG 605

  Fly   892 IQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCS 956
            :.|.::.:||.||:||....|.:.| ..:.:.:|||:|||||||.|.|||:||:|::|..|.|..
Human   606 LNWAFIGVDEAHRLKNDDSLLYKTL-IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWE 669

  Fly   957 TFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSA 1021
            .||:       ..|:..|..       ...|||.|.||||||:||:||..||.|||.|::.:|||
Human   670 DFEE-------EHGKGREYG-------YASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA 720

  Fly  1022 LQRVLYKHMQSKGV-LLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQ-------HIEEKY 1078
            ||:..||.:.::.. .|:.||      ||.....:|.:::|:|.|||.::.:       :.:::.
Human   721 LQKQYYKWILTRNYKALSKGS------KGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEA 779

  Fly  1079 CDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLR 1143
            ..|           |.|.|||..|||::|.:|:...:|||:|.||.:.:.|:.:||.:|||.:.|
Human   780 LQH-----------LIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQR 833

  Fly  1144 LDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRA 1208
            |||:.|.|.|.:.|..|||:||:.|.|||||||||||:||.:|||||||||||||..|||||.||
Human   834 LDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARA 898

  Fly  1209 HRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ-----------AGMFDQKSTGSERQ 1262
            |||||:.:|.:.||:|..||||.||..|:.|:.:|..|||           .|.....||...::
Human   899 HRIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKE 963

  Fly  1263 QF-------LQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPG- 1319
            :.       .:.:..:.:.||:|..|:..||::                    ::.|..|..|| 
Human   964 ELSAILKFGAEELFKEPEGEEQEPQEMDIDEIL--------------------KRAETHENEPGP 1008

  Fly  1320 ---RERLIDESELPDWLTKDDDEV----ERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWL-- 1375
               .:.|:.:.::.::...|:|::    ||....::|  |:....|:|.|.:......|:.::  
Human  1009 LTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEE--IIPEDQRRRLEEEERQKELEEIYMLP 1071

  Fly  1376 ------KAID-DGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLI-----LKRRR-----RQNLD 1423
                  |.|. :|:|            .||.|..|...||.||:.     .||.|     |:|:.
Human  1072 RMRNCAKQISFNGSE------------GRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIK 1124

  Fly  1424 KRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKI--------LQRI 1480
            ..|..::.:.:.:..|       ...|..:|.:..|  |...:.|...|::::        ::.:
Human  1125 GFSDAEIRRFIKSYKK-------FGGPLERLDAIAR--DAELVDKSETDLRRLGELVHNGCIKAL 1180

  Fly  1481 EDCKYAD------LNELEKDFMQLC---QNAQ--IYNEEASLIYLDSIALQKVFVG---ARQRIT 1531
            :|.....      |.:::....::.   .||:  |.:||      :.|.|.|....   .|::.|
Human  1181 KDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEE------ELIPLHKSIPSDPEERKQYT 1239

  Fly  1532 AAADAAAVAAGDNTGE-----------AHGNGGSDNSDNDDD---------DGGDDGSDDEEIAT 1576
            ......|.....:.|:           .:|.|..:....|.|         |..|.....:::.|
Human  1240 IPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQT 1304

  Fly  1577 TSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTI-------SD--- 1631
            .:...:|:   |::.||...|.         |||.::.:::.|.|:::...:|       ||   
Human  1305 RADYLIKL---LSRDLAKKEAL---------SGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSP 1357

  Fly  1632 ------DDDDDMDXL 1640
                  |:|||.| :
Human  1358 LPSEKSDEDDDKDEI 1372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 173..202 CDD:462622
Pro-rich <247..401 CDD:464580
PTZ00121 <477..651 CDD:173412 30/199 (15%)
HSA 501..573 CDD:214727 10/74 (14%)
BRK 650..691 CDD:462196 10/48 (21%)
PLN03142 739..>1368 CDD:215601 248/679 (37%)
Bromo_SNF2L2 1425..1530 CDD:99947 19/126 (15%)
CHD1NP_001351042.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..252 24/155 (15%)
CD1_tandem_CHD1-2_like 276..354 CDD:349313 15/82 (18%)
CD2_tandem_CHD1-2_like 387..443 CDD:349308 9/55 (16%)
DEAD-like_helicase_N 460..697 CDD:475120 99/251 (39%)
PLN03142 464..>1000 CDD:215601 229/587 (39%)
DEAH box 614..617 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1080..1120 14/51 (27%)
CDH1_2_SANT_HL1 1124..1210 CDD:477096 10/94 (11%)
DUF4208 1496..1586 CDD:464035
U2AF_lg 1640..>1734 CDD:273727
U2AF_lg 1688..>1797 CDD:273727
HisXaaSer_A3 <1719..1750 CDD:439608
Blue background indicates that the domain is not in the aligned region.

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