Protein Alignment brm and chd1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_031749152.1
• Gene: chd1 / 100485675
• XenbaseID: XB-GENE-960477
• Length: 1797
• Species: Xenopus tropicalis
• Alignment Length: 1312
• Identity: 362/1312 - (27%)
• Similarity: 570/1312 - (43%)
• Gaps: 317/1312 - (24%)

  Fly   532 RNNKAQLARMNKAVMNHHANAEREQKKEQERIE-------KERMRRLMAEDEEGYRKLIDQKKDK 589
            :|.|:|    |::.:.:...:..::|::.:..:       .:|:.|..|.....|::..:.|.|
 Frog   192 KNKKSQ----NRSKVKNGKTSAGQKKRDADSSDDDYDDDYNKRVSRRQATVNVSYKEDEEMKTD- 251

  Fly   590 RLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRV 654
                    :|:.:..:.:.|.|.::|:.:..|.            :|...: | .:|:......:
 Frog   252 --------SDDLLEVIGEDVPQPEEDEFETIER------------VMDSRF-G-RKGATGGTTTI 294

  Fly   655 HVVE-------QCTGKKLTGDDAPMLKHLHRWLNMHPGWDWID--DEEDSCGSN--DDHKPKVEE 708
            :.||       .....|..|:...:|| ...|.::|..|:..|  .:::..|..  |::|.|.:|
 Frog   295 YAVEADGDPNANFNETKEAGETQYLLK-WKGWSSIHNTWETEDTLKQQNVKGMKKLDNYKKKEQE 358

  Fly   709 -----QPTATED---------------------------ATDKAQATGND--------------- 726
                 :..:.||                           :..|:.|...|
 Frog   359 KKRWLKAASPEDIEYYNCQQELIDDLHKQYQIVERIIAHSNQKSAAGYPDYFCKWQGLPYSECSW 423

  Fly   727 EDAKDLITKAKVEDDEYRTEEQTYYSIAHTI---HEKVVEQASIMV---------NGT----LKE 775
            ||...:..|.:...|||.:..|     :.||   ..||::|....|         .|.    |::
 Frog   424 EDGALIAKKFQARIDEYISRNQ-----SKTIPFKECKVLKQRPRFVALKKQPSYIGGNKQLELRD 483

  Fly   776 YQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLE 840
            ||:.||.||...:....:.||||||||||||||||.:.||....::.||:|::||||||.:|..|
 Frog   484 YQLDGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQRE 548

  Fly   841 FEKWAPAVGVVSYKGSPQGRRLLQN------QMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMII 899
            .:.|||.:..|.|.|....|.:::.      |.:..|.||||||||.::|||:.|..:.|.::.:
 Frog   549 IQIWAPLMNAVVYLGDINSRNMIRTHEWMHPQTKRLKLNVLLTTYEILLKDKSFLGGVNWAFIGV 613

  Fly   900 DEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNA 964
            ||.||:||....|.:.| ..:.:.:|||:|||||||.|.|||:||:|::|..|.|...||:
 Frog   614 DEAHRLKNDDSLLYKTL-IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEE---- 673

  Fly   965 PFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKH 1029
               ..|:..|..       ...|||.|.||||||:||:||..||.|||.|::.:|||.|:..||.
 Frog   674 ---EHGKGREYG-------YASLHKELEPFLLRRVKKDVEKSLPAKVEQILRVEMSASQKQYYKW 728

  Fly  1030 MQSKGV-LLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEE-------KYCDHTGGHG 1086
            :.::.. .|:.||      ||.....:|.:::|:|.|||.::.:..||       :...|
 Frog   729 ILTRNYKALSKGS------KGSTSGFLNIMMELKKCCNHCYLIKPPEENEFYNRQEALQH----- 782

  Fly  1087 VVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAE 1151
                  |.|.|||..|||::|.:|:...:|||:|.||.:.:.|:.:||..|||.:.||||:.|.|
 Frog   783 ------LIRSSGKLILLDKLLVRLRERGNRVLIFSQMVRMLDILAEYLKSRQFPFQRLDGSIKGE 841

  Fly  1152 DRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNE 1216
            .|.:.|..|||:||:.|.|||||||||||:||.:|||||||||||||..|||||.|||||||:.:
 Frog   842 VRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQ 906

  Fly  1217 VRVLRLMTVNSVEERILAAARYKLNMDEKVIQ-----------AGMFDQKSTGSERQQF------ 1264
            |.:.||:|..||||.|:..|:.|:.:|..|||           .|.....||...:::.
 Frog   907 VNIYRLVTKGSVEEDIIERAKKKMVLDHLVIQRMDTTGKTVLHTGSTPSSSTPFNKEELAAILKF 971

  Fly  1265 -LQTILHQDDNEEEEENEVPDDEMINMMIAR---------SEEEIEIFKRMDAERKKEDEEIHPG 1319
             .:.:..:.:.||||..|:..||::.....|         .:|.:..||..:....:||:.:.|.
 Frog   972 GAEELFKEPEGEEEEPQEMDIDEILKRAETRENEGGPLTVGDELLSQFKVANFSTMEEDDMVEPN 1036

  Fly  1320 RERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEF 1384
            |:....|..:|....:..:|.|| ..:..|..:|.|.....|:.::              :|:|
 Frog  1037 RDSKSWEDIIPTDQRRRMEEEER-EKELQEIYLLPRMRNCAKQANF--------------NGSE- 1085

  Fly  1385 DEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSE 1449
                       .||.|..|...||.||:..::|.:    ||.:.:      .:.:.|..|
 Frog  1086 -----------GRRSRNRRYSGSDSDSMSDRKRPK----KRGRPR------TIPRENIKG----- 1124

  Fly  1450 PFMKLPSRQRLPDYYEIIKRPVDIKKI---LQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASL 1511
             |.....|:.:..|          ||.   |:|: |....|...::|....|.:..::.:.....
 Frog  1125 -FSDAEIRRFIKSY----------KKFGGPLERL-DAIARDAELVDKSETDLRRLGELIHSGCIK 1177

  Fly  1512 IYLDSIALQKVFVGARQ--------RITAAADAAAVAAG--DNTGEAHGNGGSDNSDN------- 1559
            ...||...::  .|.|:        ||:.....|.:.:.  |.....|.:..||..:.
 Frog  1178 ALKDSSGQER--AGGRRGKMKGPTFRISGVQVNAKLVSSHEDELAPLHKSIPSDPDERKRYVIPC 1240

  Fly  1560 -------DDDDGGDDGSD----DEEIATTSAAAVKMKLKLNKSLASAPATP-------------- 1599
                   |.|.|.:|.|:    ..|....|...:||...||.:....|..|
 Frog  1241 HTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLNLTQKILPDDPDKKPQAKQLQTRAD 1305

  Fly  1600 -----------TQSSSNVSSGAATTSKKQTRRKRSQKKYTI-----------------SDDDDDD 1636
                       .:.:..:||| ..:.:::||.|:|:....:                 |::::|.
 Frog  1306 YLIKLLNKDLLRKEAQRLSSG-GNSKRRKTRAKKSKNVKPVKVEEETKSESSPPSSENSEEEEDQ 1369

  Fly  1637 MDXLPLGVIFKR 1648
            .:.:||....||
 Frog  1370 EETVPLRTNNKR 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	19/125 (15%)
		HSA	501..573	CDD:214727	7/47 (15%)
		BRK	650..691	CDD:462196	10/49 (20%)
		PLN03142	739..>1368	CDD:215601	257/685 (38%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/115 (16%)
chd1	XP_031749152.1	CD1_tandem_CHD1-2_like	270..354	CDD:349313	16/98 (16%)
		CD2_tandem_CHD1-2_like	387..443	CDD:349308	9/55 (16%)
		PLN03142	464..>1000	CDD:215601	231/567 (41%)
		CDH1_2_SANT_HL1	1123..1208	CDD:477096	18/103 (17%)
		DUF4208	1491..1581	CDD:464035
		U2AF_lg	1669..>1778	CDD:273727
		HisXaaSer_A3	<1705..1744	CDD:439608