Protein Alignment brm and chd3

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_002940874.3
• Gene: chd3 / 100216299
• XenbaseID: XB-GENE-1008908
• Length: 2036
• Species: Xenopus tropicalis
• Alignment Length: 1489
• Identity: 392/1489 - (26%)
• Similarity: 618/1489 - (41%)
• Gaps: 370/1489 - (24%)

  Fly   354 PQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKP--VGLDPITLLQERENRIA 416
            |......|.:|......:.|.||..:         ||.:...||:|  ||           .:..
 Frog   279 PTTATVTPALPMRRAKTKEGKGPGHK---------KPYKSPRVAEPKKVG-----------KKKM 323

  Fly   417 ARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYK 481
            |.:.:|:..::|...:.||::.:..|.:|....|.:          .....|::          .
 Frog   324 APLKIRLAGMKRKAGSSSEEIDVGEASDLENSSVHS----------SSAPSDSS----------G 368

  Fly   482 RTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDL-------REFH---RNNKA 536
            |.||:..|.||..:|:..::.:.|.......|.:: ..|.|.|.::       |.:|   ...:.
 Frog   369 RVKRKRGRPARKKKKVAVEEGVSAGEGYETDHQDY-CEVCQQGGEIILCDTCPRAYHLVCLEPEL 432

  Fly   537 QLARMNKAVMNHHANAERE----QKKEQERIEKERMRRLMAEDEEGYRKLIDQKKD--KRLAFLL 595
            :.|...|....|   .|:|    :.||.|..|.|..:|...|:|:.:.:.....||  :.|....
 Frog   433 ERAPQGKWSCPH---CEKEGVQWEAKELEEEEMEEPKRERREEEDDHMEFCRVCKDGGELLCCDA 494

  Fly   596 SQTDEYISNLTQMVKQ--HKD--------DQMKKK--------------------------EEEG 624
            ..:..:|..|...:..  |.:        .|:|.|                          :||.
 Frog   495 CVSSYHIHCLNPPLPDIPHGEWLCPRCTCPQLKGKVQKILHWRWGVPPEGVPLPQPLDGAQDEEP 559

  Fly   625 KRLIQFKKELLMSGEYIGIDEGSI--VADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMH--PG 685
            .|.:|.:.|.....::.|:.....  :.::::.:..           ..|.::..|..:|.  |.
 Frog   560 PRALQGRSEREFFVKWAGMSYWHCCWITELQLEIFH-----------TVMYRNFQRKNDMDEPPP 613

  Fly   686 WDW--IDDEEDSCGSNDDHKPKVEEQ-------------PTATEDATDKAQATGN---------- 725
            :|:  .:||..|..|.|.....:||:             ......:.||   .||
 Frog   614 FDYGSGEDEGKSEKSKDAEYSDLEERFYRYGIKPEWMSIQRIINHSLDK---RGNYHYLVKWRDL 675

  Fly   726 -------DEDAKDLITKAKVEDDEY---------------------RTEEQTYYSIAHTIHEKVV 762
                   :|||      .|:.|.||                     :.:.|...|..|.:....:
 Frog   676 SYDQSTWEEDA------MKLPDYEYHKPLYWRHRQLMMGDSACCPQKYKRQHKESYLHGVPSSPI 734

  Fly   763 EQASI----------MVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMD 817
            ...::          ...|||..||::||.||...:....:.|||||||||||||||..:..|..
 Frog   735 NDPTVKYDTQPQFVSSTGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYK 799

  Fly   818 RKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQN----------------- 865
            .....||:|:..||||:.||..||:.|||...||:|.|....|.:::.
 Frog   800 EGHTQGPFLVSAPLSTIINWEREFQMWAPDFYVVTYTGDKDSRSVIRENEFSYQDNVMKGGKKAF 864

  Fly   866 QMRA---TKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLL 927
            :|:|   .||:||||:||.|..|:|.|..|:|..:::||.||:||:..|..:|||.:.| .|:||
 Frog   865 KMKAQAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYQI-DYKLL 928

  Fly   928 LTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLR 992
            ||||||||.|.||:.|||||.|..|.:...|.:.|          .::::|:.   |::||.:|.
 Frog   929 LTGTPLQNNLEELFHLLNFLTPERFNNLDGFLEEF----------ADISKEDQ---IKKLHDLLG 980

  Fly   993 PFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK-GKHGKGGAKALMN 1056
            |.||||:|.:|...:|.|.|.|::.::|.:|:..||      .:||...|. ...|.|...:|:|
 Frog   981 PHLLRRMKADVFKNMPAKTELIVRVELSPMQKKYYK------FILTRNFEALNSRGGGNQVSLLN 1039

  Fly  1057 TIVQLRKLCNHPFMF--QHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLL 1119
            .::.|:|.||||::|  ..:|.....    .|...|..|.:.|||..||.::|.||....||||:
 Frog  1040 IMMDLKKCCNHPYLFPAASLESPKLP----SGAYEGGSLVKASGKLLLLHKMLRKLNEQGHRVLI 1100

  Fly  1120 FCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQ 1184
            |.|||:.:.|:||:|.:..:.|.|:||......|.|.:.:|||.|:..|.|||||||||||:||.
 Frog  1101 FSQMTKMLDILEDFLDFEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLA 1165

  Fly  1185 TADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQA 1249
            |||||:|:|||||||.|:||..|||||||.|:|.:.|.:|..||||||...|:.|:.:...|::.
 Frog  1166 TADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRP 1230

  Fly  1250 GMFDQKSTGSERQQFLQTIL------------HQDDNEEEEENEV------------------PD 1284
            |:  ....||..:|.|..||            ...||:|::.:.:                  .|
 Frog  1231 GL--GSKAGSMSKQELDDILKFGTEELFKDEIEAGDNKEDDSSVIHYDNGAIDRLLDRNQDVTED 1293

  Fly  1285 DEMINM-----------MIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDD 1338
            .|:.||           .:.|.||::|   .::.|..|::|.:.|..           |     :
 Frog  1294 TEVQNMNEYLSSFKVAQYVVREEEKLE---ELEREVIKQEENVDPDY-----------W-----E 1339

  Fly  1339 EVERFHYQYDEDTI---LGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEF---DEEEEEDDSKR-- 1395
            ::.|.||:..::.:   ||:|.|.||:|:|.|:..|.:     |:.:|:   .|||:||..:|
 Frog  1340 KLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQ-----DNQSEYSVGSEEEDEDFDERAE 1399

  Fly  1396 -KRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQR 1459
             :|:.|:..:.|.|.....|..|...|::             |:..|...|   :.|:....|..
 Frog  1400 GRRQSRRQLRNEKDKPLPPLLARVGGNIE-------------VLGFNTRQR---KAFLNAVMRWG 1448

  Fly  1460 LPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDF--------MQLCQNAQIYNEEASLIYLDS 1516
            :|        |.|.......:.|.:    .:.||:|        ..||:.    ..:.|..:.|.
 Frog  1449 MP--------PQDAFSTHWLVRDLR----GKSEKEFKAYVSLFMRHLCEP----GADGSETFADG 1497

  Fly  1517 IALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIAT-TSAA 1580
            :..:.:   :||::.......::.........|.||.....:...|.     |.|.:::: .|:.
 Frog  1498 VPREGL---SRQQVLTRIGVMSLVKKKIQEFEHINGRWSMPELMPDP-----SLDSKLSSRASSP 1554

  Fly  1581 AVKMKLK------LNKSLASAPATPTQSSSNVSSG-------AATTSKKQTRRKRSQKK 1626
            .||....      .|....|.||||..|....:.|       |....:|:...|.::|:
 Frog  1555 TVKTSTTTPEPSLTNTPCTSKPATPAPSERGENGGTPVDTGEAECKEEKENDLKGTEKR 1613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	11/48 (23%)
		PTZ00121	<477..651	CDD:173412	42/227 (19%)
		HSA	501..573	CDD:214727	18/85 (21%)
		BRK	650..691	CDD:462196	5/44 (11%)
		PLN03142	739..>1368	CDD:215601	252/726 (35%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/112 (16%)
chd3	XP_002940874.3	CHDNT	195..250	CDD:462357
		PHD1_CHD_II	403..445	CDD:277006	8/45 (18%)
		PHD2_CHD_II	479..521	CDD:277007	6/41 (15%)
		CD1_tandem_CHD3-4_like	526..604	CDD:349314	9/88 (10%)
		CD2_tandem_CHD3-4_like	647..701	CDD:349309	11/62 (18%)
		PLN03142	738..>1293	CDD:215601	222/580 (38%)
		DEXHc_CHD3	755..986	CDD:350813	100/244 (41%)
		DUF1087	1327..1377	CDD:461922	17/65 (26%)
		CHDII_SANT-like	1398..1537	CDD:461920	28/173 (16%)
		PspC_subgroup_2	<1535..1750	CDD:468202	18/84 (21%)
		CHDCT2	1781..1926	CDD:462358