Protein Alignment brm and LOC100145162

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001265364.2
• Gene: LOC100145162 / 100145162
• XenbaseID: XB-GENE-29077487
• Length: 2919
• Species: Xenopus tropicalis
• Alignment Length: 2607
• Identity: 461/2607 - (17%)
• Similarity: 779/2607 - (29%)
• Gaps: 1188/2607 - (45%)

  Fly     4 PSPANSPMPPPQAPSPMAPP--------SQSPAPSPHSPYPHQQPG--------------PLQGP 46
            ||||.|..|...:|:|.:|.        |::|.|..:.....|..|              |:..|
 Frog    33 PSPAQSFTPTVSSPAPQSPSYQIQHLIMSRNPMPGQNVNITLQNVGPVVAGGQQITLTSLPISSP 97

  Fly    47 PPPG-----HPGAYGH---------------------------PMQH------------------ 61
            ..||     .|..:.|                           |:|.
 Frog    98 ASPGFQFNTQPRRFEHGSPSYIQVTSPVSQQVQTQSSTQPNTVPIQALQGVRTGTSSASLGMCSQ 162

  Fly    62 ------------------GPPGQGP---------------------------PGHHM-------- 73
                              ||...|.                           |.|.:
 Frog   163 SPTRGFVDAGLLVRQLSLGPSNTGTFVIQEGSGLTQIAQSAQVHLSPGTPTVPAHSLLHSNSQAV 227

  Fly    74 -PPHHQGMIFSKGPHMGMQMPPT-------------------------------GPNMS-----P 101
             |.|..|...|....:.:|.|.|                               ||.:|     .
 Frog   228 GPVHQFGSQSSVAGSVNVQSPSTPSHLTTNLSQQLSSIIQGQIIQQQQQQQLLHGPQVSRTFSFD 292

  Fly   102 YQTHGM----------------PPNAPTQ----------PCIVSPGGPPGGPPPPERSSQENLHA 140
            ..:.||                .|.:|:|          |...:||                 ..
 Frog   293 RTSSGMIAGISGNSAFGITSAATPTSPSQVTGPQAFSSLPLTTAPG-----------------TT 340

  Fly   141 LQRAIDSMEE--KGLQEDP---------RYSQLLAMRATSKH--------QHLNGNQVNLL--RT 184
            |::....:||  ...|||.         .:.|:.|::.|...        ||..||.::.|  :.
 Frog   341 LKKQTKKLEEIPPATQEDALLRKLCLDHHHQQMQALKETYTEYLIELFFLQHCQGNMMDFLPFKK 405

  Fly   185 QITAYRLLARNKPISMQMQQ------ALQAAQQQPPPGPPIGPPGAPG-----GPPPGSQHAGQP 238
            :...|:...|...:.:::.:      :.||...|.|..|......||.     ...|..:.:..|
 Frog   406 KRNIYQNFLRQNDLDLEVDEEETEKNSSQAVYVQTPDPPASSVIEAPADMEIQASDPAMKQSQSP 470

  Fly   239 ------PVPPQQQQQPPPSAGTPPQCST-----------------PPASNPYG------PPVPGQ 274
                  |:.|....:....||..|...|                 ..|:.|..      |.:|..
 Frog   471 MVTLGLPLLPPVTARSVMDAGMSPSKQTCTSVANKQNDAAKISMLQNAAGPQSPFRTQLPTMPVS 535

  Fly   275 KMQVAPPPPHMQQGQPLPPQP------PQVGGPPPIQQQ--QPPQQQ-----QQQSQPPPP---- 322
            .:|.|   .|:.|.|.|..:.      .|..|.||:..|  ||.|::     ....|||.|
 Frog   536 SVQTA---MHLAQQQQLITEAHSQTMVKQSSGQPPLHNQSAQPSQEKMVDHFSSLKQPPVPASAS 597

  Fly   323 ----EPHQHQLPNGGKPLSMG------PSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPG-GGP 376
                :..:..:..|.||.|:.      |....|.:..||.:....|....:.|.|:  .|| .||
 Frog   598 KMGSDSVKTAVSVGLKPTSLTSPSPSIPDSVPPAVAVSPKRILSPGASKAVSPASR--SPGLAGP 660

  Fly   377 QRQVPPAGMPMP-KPNRITTVAKPVGLDPITLLQERENRIAARIS-LRMQEL---QRLPATMSED 436
            |.|.|....|:| ...:...|.|||         |:|:.|..||: ||.:.:   :|||
 Frog   661 QSQEPQCLAPVPGDAQQEALVPKPV---------EQESHIHQRIAELRKEGMWSPRRLP------ 710

  Fly   437 LRLQAAIELRAL--RVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEK 499
             |||.....::.  .:|.....:..:|.|             .:|:|:...:.|....|....||
 Frog   711 -RLQEPCRTKSHWDYLLEEMSWMAADFAQ-------------ERLWKQACAKKLVRTAARHCQEK 761

  Fly   500 QQKLEAERKR----RQKHLEFLAAVLQHGKDLREFHRN-NKAQLARMNKAVMNHHANAEREQKKE 559
            ||| :|..|:    |.:.:.:|||     ::::.|..| .:....::...:......|...|||.
 Frog   762 QQK-DARAKKEDEDRLRRIAWLAA-----REIQYFWSNIEQVVEIKLQVELQEKMKRAFSAQKKL 820

  Fly   560 QERIEKERMRRLMAEDEEGYRKLIDQKKDKRLA-----FLLSQTDEYISNLTQMVKQHKDDQMKK 619
            .:.:|.:::        :...|:||.....::|     :|.:..  |:.|:
 Frog   821 HKGVEPKKL--------DAQNKVIDIVYQVKIAVCACTYLFTML--YVPNV-------------- 861

  Fly   620 KEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHP 684
                   |::.||:..:||                                         .|::|
 Frog   862 -------LLRAKKDQAISG-----------------------------------------TNINP 878

  Fly   685 GWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQT 749
            ....:::.|::..::.:.|..:..:...|.:.:: ....|..:..:|:...|
 Frog   879 ESSRVENNENAVKADGNQKAVISIEALLTIEGSN-TTPLGARKHCRDIAEVA------------- 929

  Fly   750 YYSIAHTIHEKVVEQASIMV--------NGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTI 806
              :.|..:..:...:.|.:|        :|||:|||..|:||||..|..|||||||||.||||.|
 Frog   930 --AAAELLLPRGSSRISCLVKTSQLPLLHGTLREYQQVGVEWLVKQYKKNLNGILADETGLGKNI 992

  Fly   807 QTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGS-PQGRRLLQNQMRAT 870
            |.|:|.::|...:.|.|||||:.....:..|.||.::|.||:.::.|.|| .:.||..|......
 Frog   993 QVIALFSHLASNEGVWGPYLIVARSCKILKWELELKRWCPALKILLYFGSQSELRRKRQTWNEPN 1057

  Fly   871 KFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQ-----VLNTHYIAPYRLLLTG 930
            .|||.:|:|:...|......|::|||:::||.|::||    :|:     :||..  :..||||..
 Frog  1058 NFNVCITSYKQFFKSHKAFKKMRWKYLVLDEVHQIKN----MTEMHWEAILNLP--SQRRLLLRD 1116

  Fly   931 TPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEE-----TILIIRRLHKV 990
            .||.:...|||.:::||:|.:.::...|             .|..|:::     ||.|  |||:.
 Frog  1117 NPLPHTWKELWTMVHFLIPGLSRAYLDF-------------PVNENDQDHDYRHTISI--RLHRS 1166

  Fly   991 LRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALM 1055
            .:||:|||.|::||.||..|.|:::||.:|..||.||     :.|::..|::....| |...:::
 Frog  1167 TQPFILRRSKRDVERQLTKKSEHVLKCQLSNRQRALY-----EDVMMQPGTQDALKG-GHFVSVL 1225

  Fly  1056 NTIVQLRKLCNH-----------PFMFQHIEEKYCD----------------------------- 1080
            :.::||:::|||           .:.|:.|:.|...
 Frog  1226 HVLMQLQRICNHTELVDPRLKHSSYAFKAIKYKTASLILRALLRDPWKNVELASLNLIGMENNMT 1290

  Fly  1081 ----------------------------------------------------------------- 1080
                                                                             
 Frog  1291 RFEAQVLPKQKVTRKLIQEIYNSPNPPVRPSRVKIKPSRLFEPVLYGQKPEGRTVTFPSAPQTRT 1355

  Fly  1081 ----------------------------------------------------------------- 1080
                                                                             
 Frog  1356 VTQTTATVSQQGQVRRSPVTTPAVPQGAKAPATQGHTPPVQVGAPRPQAPAAFATAAPVRQLSQP 1420

  Fly  1081 ------------------------------HTGG------------------------------- 1084
                                          .|||
 Frog  1421 PQQNIPSPRLVLSSQARLPTGELVKIAQLASTGGAQGRVAQPETPVTLQFQGNKFTLSQSQLRQL 1485

  Fly  1085 --------HG----VVSGPDLY------------------------------------------- 1094
                    ||    :||.|..|
 Frog  1486 TAGQPLQLHGNVLQIVSAPGQYLRPQGSVVLPTMPQGTTTNTVRSQNPVGAPLPSTVSSTGLVAG 1550

  Fly  1095 --------------------------------RV------------------------------- 1096
                                            ||
 Frog  1551 RNVQTCSTTADSVPKSNQAVVSPAQESAEEKQRVIKERLDRLFFCNELRCARAPIYGTDLLSFCS 1615

  Fly  1097 ----------------------------------------------------------------- 1096
                                                                             
 Frog  1616 LNSPGAWPPSQGTVWSWTGSVNCFLSSHSPENSSDLLRHLIPSHDQQKASLEPLAKSALCVVPPV 1680

  Fly  1097 ----------------------------------------------------------SGKFELL 1103
                                                                      |||.|.|
 Frog  1681 VAATPVLMVPNPPPAYIHSLKRLEHGLRDQLAPVLCELRERTTPHCLPFPDLKLIQADSGKLEAL 1745

  Fly  1104 DRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVF 1168
            ..:|.||::...|||:|.||...:.|:|.:|.:....:||:|....:|...:|::.|| :...:|
 Frog  1746 AVLLRKLRSEGRRVLIFSQMLLMLDILELFLDFHSLTFLRIDDNANSEQCQDLMKTFN-RDQRIF 1809

  Fly  1169 VFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERIL 1233
            ..||||....||.....||||:.:|||.||..|.:.|.....:|:..::.|.||::.||:||::|
 Frog  1810 SVLLSTHIPNLGAYQVEADTVIFYDSDLNPVMDGKTQSWCDLVGRSKDIHVYRLVSANSIEEKLL 1874

  Fly  1234 ----------AAAR---YKLN-MDEKVIQAGMFD----QKSTGSERQQFLQTILHQDDN------ 1274
                      .||:   |.|. :.::.||. :|:    .:.:|.:.::|:  :|.|:.:
 Frog  1875 RNGTKDLIREVAAQGSDYSLAFLTQQTIQE-LFEVCSPLEDSGVKAEEFV--LLSQEPSPSDTIT 1936

  Fly  1275 ------------EEEEENE-----VPDD--------------------------EMINMMIARSE 1296
                        |.|..||     |.:|                          |::.:|...:.
 Frog  1937 AKVAKPFVEALVEIEHINEDITDPVEEDGPNANTGISHAVNGEPVGLSEPSQFQELVELMQQLTP 2001

  Fly  1297 EE------IEIF--KRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTIL 1353
            .|      :|:|  :|.:|..:..:|:::..: |..|...|.:  .|:.:||:   ::.:|:.:|
 Frog  2002 IEKYALHYLELFHIQRAEAHDECTEEKLNAAK-REWDSKHLRE--LKEREEVQ---WEAEEEELL 2060

  Fly  1354 GRGSRQRKEVDY----TDSLTE--KEWLKAIDDGAEFDEEEEED-----------------DSK- 1394
            .........:|:    ||..||  ..|....      ..::|.|                 :||
 Frog  2061 TYTREDAYNMDFIYDGTDGQTELMPVWTPPT------PPQDENDIYIDSVMCLMYDTNPIVESKL 2119

  Fly  1395 -----RKRRKRK--------NRKEESDDDSLI-------------LKRRR-----RQNLDKRSKK 1428
                 ||.|||.        .:|:....:|::             ||.|:     ::|:..:.:.
 Frog  2120 PPVYMRKERKRHKTDPTAAGRKKKMRHGESVVPPRSLFDRAVPNPLKVRKEGKEQKKNILLKQQT 2184

  Fly  1429 QMHKIMSAVIKH-------------NQDGRTLS--EPFMKLP------SRQRLPDYYEIIKRPVD 1472
            |..|.:..:||.             ::|...|.  :..::||      |....|: ::::...|:
 Frog  2185 QFAKPLPTLIKPVMESGPDNPEWLISEDWALLQTVKQLLELPLNLSVISPAHTPN-WDLVSDVVN 2248

  Fly  1473 -IKKILQRIEDC--KYADL----NELEKDFMQLCQNAQIYNEEA----SLIYLDSIALQKVFVGA 1526
             ..:|.:..:.|  :|.::    .|.:.:..:..:.:|||.::.    |.::.....|.|:..|.
 Frog  2249 SCSRIYRSSKQCRSRYENVIIPREEGKSENTKPLRTSQIYAQDEGMTHSQLFATRFELMKIIAGK 2313

  Fly  1527 R-------------------------------------QRITAAADAAAVAAGDNTGEAHGNGGS 1554
            |                                     |..:..||..|........:|.....|
 Frog  2314 RSQPSKPVLGGNPFQKNPKHASVLAESGINYDKPLPPTQVASLRADRIAKEKKALVEQARAQQQS 2378

  Fly  1555 DNSDNDDDDGGDD----------GSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQ--SSSNVS 1607
            ..|.......|..          .|..:::|.|.:..|   ::..:.:..||:|.|.  ||..:.
 Frog  2379 GPSQQQPQQNGQQPAQTATVQPVQSQTQQLAVTQSQVV---VQQQQQVTKAPSTNTTPISSPALL 2440

  Fly  1608 SGAATTS 1614
            :||..|:
 Frog  2441 TGAIKTT 2447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	6/30 (20%)
		Pro-rich	<247..401	CDD:464580	49/205 (24%)
		PTZ00121	<477..651	CDD:173412	34/183 (19%)
		HSA	501..573	CDD:214727	15/76 (20%)
		BRK	650..691	CDD:462196	2/40 (5%)
		PLN03142	739..>1368	CDD:215601	218/1198 (18%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/173 (14%)
LOC100145162	NP_001265364.2	EP400_N	1..431	CDD:434938	61/414 (15%)
		PRK12323	<508..>688	CDD:481241	47/193 (24%)
		HSA	710..780	CDD:214727	19/90 (21%)
		DEAD-like_helicase_N	959..1174	CDD:475120	88/235 (37%)
		PHA03378	<1316..1542	CDD:223065	9/225 (4%)
		SF2_C_SNF	1733..1864	CDD:350180	45/131 (34%)