Protein Alignment brm and ercc6l

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_002936822.1
• Gene: ercc6l / 100135235
• XenbaseID: XB-GENE-988849
• Length: 1361
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 308/1160 - (26%)
• Similarity: 487/1160 - (41%)
• Gaps: 294/1160 - (25%)

  Fly   691 DEEDSCGSN---DDHKPKVE-EQPTATEDATDKAQ---ATGNDEDAKDLITKA-----------K 737
            :|..|.|||   |.|:.:|| ||....|....||:   .:||.|.|.....||           :
 Frog     4 EERPSTGSNEPGDLHRSRVEPEQVERYELYVKKAKQEATSGNLEKAIKFFVKASEIHPSDKIHRR 68

  Fly   738 VEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVN---GTLKEYQIKGLEWLVSLY-NNNLNGILAD 798
            :|..:...||......|......|:.....:.|   ..|.|:|.:|:.:|.||| :....|||||
 Frog    69 IEKLKEALEELDLQEDADDDFVDVLNSGLTIYNELYNKLFEHQKEGVAFLYSLYRDGRKGGILAD 133

  Fly   799 EMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLL 863
            :||||||||.|..::.:.| .:::...|:::|.:.:.|||.||:||.|.:.|..:.|:.:..|..
 Frog   134 DMGLGKTIQVIGFLSGMFD-SELIKYVLLVMPTTLISNWVKEFQKWTPGLRVAEFHGTSKKERTR 197

  Fly   864 QNQMRATKFNVLLTTYEYVIKDKAVLA-----KIQWKYMIIDEGHRMKNHHCKLTQVLNTHYI-A 922
            ..:.......:::|||:.:|.:...||     :.:|.|:|:||.|::|....|..:  :.|.| |
 Frog   198 NLEKIQRMSGIIITTYQMLINNWQQLATYNGREFEWDYIILDEAHKIKTSSTKTAK--SCHSIPA 260

  Fly   923 PYRLLLTGTPLQNKLPELWALLNFLLP-SIFKSCSTFEQWFNAPF-------ATTGEK---VELN 976
            ..|:||||||:||.|.|:|||.:|... ::..:..||:..:..|.       ||.|||   ::::
 Frog   261 KNRILLTGTPIQNNLREMWALYDFACQGTLLGTSKTFKMEYENPITRAREKDATPGEKALGLKIS 325

  Fly   977 EEETILIIRRLHKVLRPFLLRRLKKEVEHQ------------------LPDKVEYIIKCDMSALQ 1023
            |        .|.|:::|:.|||.|.:|:::                  |..|.::|:...:|.:|
 Frog   326 E--------NLMKIIQPYFLRRTKSDVQNKKTERTRAQDTSQGPSMPSLTRKNDFIVWVYLSTIQ 382

  Fly  1024 RVLYKHM----QSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQ---------HIE 1075
            ..:|:..    |.|.:|:|..|         ..|.:|.   |:|||:||.:..         ..:
 Frog   383 EDVYRKFISLDQIKELLMTTRS---------PLAELNI---LKKLCDHPRLLSARACIQLGLEGD 435

  Fly  1076 EKYCDHTGGHGVVSGPD------LYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYL 1134
            :.:.:..|.|.:|:..|      |...|||..||..:|.|||...||.|:|.|..:.:.:|:..|
 Frog   436 DYHSNEEGDHELVTKFDHLSDEILIEESGKLLLLIDLLHKLKEEGHRTLVFSQSRKMLDMIDRIL 500

  Fly  1135 GWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPH 1199
            ..:.|..:|:|||....:|.:.:..|.: .::..|.||:|:.||:||.|..||.|||||..|||.
 Frog   501 QNKNFKVMRIDGTVALPEREKRISIFQS-NNNYSVLLLTTQVGGVGLTLTAADRVVIFDPSWNPA 564

  Fly  1200 QDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQF 1264
            .|.||.|||:||||:..|.:.||:|..:|||:|.....:|    |.:|      :::||.::..|
 Frog   565 TDAQAVDRAYRIGQQENVVIYRLITCGTVEEKIYRRQIFK----ESLI------RQTTGDKKNPF 619

  Fly  1265 -------LQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKE---DEEI--- 1316
                   |:.:...:|..                  .|..:|::.....||||.:   ||.|
 Frog   620 RYFSKQELKELFSLEDTR------------------TSSTQIQLQNMHAAERKTDTRLDEHIAYL 666

  Fly  1317 HP------GRERLIDESELPDWLTKDDDEVERFHYQYDEDTI-----LGRGSRQRKE--VDYTDS 1368
            |.      ....|:..:||.   :::|:|.|..|.||.|..:     |.:...|..|  :|....
 Frog   667 HTLQIFGISDHDLVYANELS---SQEDNEYEDEHGQYIEQRVQKAHELVQMESQLNEQLMDQIRK 728

  Fly  1369 LTEKEWLKAI-----------------------------DDGAEF----------DEEEEED--- 1391
            .||..|::.|                             ||..|.          |...|||
 Frog   729 STEGAWVRQISTAPEKPKKTSLPREKQYSSPPVTVDLTEDDVGEVSCHMTSLIINDSSGEEDVDL 793

  Fly  1392 DSKRKRRKRKNRKEESDDDS------LILKRRRRQNLDKRSKKQMHKIM--SAVIKHNQDGRTLS 1448
            .:.....|..|....|.|.|      |.|:...:|:.:|...||...|:  |:||:.:.|..|
 Frog   794 PAAPFSIKPLNGNSHSGDTSHAAEKPLKLENSLQQSHEKIFDKQEEIIVSDSSVIETDDDRNT-- 856

  Fly  1449 EPFMKLPSRQRLPDYYEIIK-------RPVDIKKILQRIEDCK---YADLNELEKDFMQLCQNAQ 1503
             |.:|....:..|...|.|.       .|:.|..:  ..|.||   ::..|..| :|.|.|....
 Frog   857 -PSLKGDWSKPSPPVTEHISYSHPAEGEPIPIWHV--EPEVCKKLRHSFGNRTE-EFQQSCVTDT 917

  Fly  1504 IYNE--EAS-------------LIYLDSI------ALQKVFVGARQRITAAADAAAVA----AGD 1543
            ..|:  |||             |:..||:      |..:...||.: |:||||..|:.    :.:
 Frog   918 DMNDGLEASLSASKSHLPCDFNLVLDDSMERDECNASMEGLEGAME-ISAAADKNAILVLEDSVE 981

  Fly  1544 NTGEAHGNGGSDNSDNDD----------------------------DDGGDDGSDDEEIATTSAA 1580
            ||.:.:|...|..|:|.|                            ::..:|.|.:..|:.||..
 Frog   982 NTSQRNGLEISMVSENGDMVVLDSSMANTSQRNVLGTSNKGAMLVLENSTEDISQEGNISETSMK 1046

  Fly  1581 AVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDD 1635
            ..:.|..||:|:.:|.......|                 |:..|:|.:..::|:
 Frog  1047 LEQEKKNLNESMETADVHIKDCS-----------------KQDFKEYPLEGEEDE 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196	308/1160 (27%)
		PLN03142	739..>1368	CDD:215601	207/712 (29%)
		Bromo_SNF2L2	1425..1530	CDD:99947	33/137 (24%)
ercc6l	XP_002936822.1	LapB	<21..123	CDD:442196	26/101 (26%)
		HepA	<106..613	CDD:440319	172/540 (32%)
		DEXHc_ERCC6L	107..339	CDD:350759	81/242 (33%)
		MPH1	<482..753	CDD:440728	86/302 (28%)
		Spy	1305..>1359	CDD:443119