DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10516 and SPSB4

DIOPT Version :9

Sequence 1:	NP_648819.2	Gene:	CG10516 / 39738	FlyBaseID:	FBgn0036549	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_543138.1	Gene:	SPSB4 / 92369	HGNCID:	30630	Length:	273	Species:	Homo sapiens

Alignment Length:	227	Identity:	61/227 - (26%)
Similarity:	102/227 - (44%)	Gaps:	37/227 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 WHATDES-DAVVTDRD-IIF--HPTYSQGTAIVRGEQALKTNMVHFWEMRVITTLAGTDVMFGIG 113
            |:..|.| :..|.|.| :.|  ||. :|.|..:||:.. ....:|.|::.......||..:.|:.
Human    56 WNPEDRSLNVFVKDDDRLTFHRHPV-AQSTDGIRGKVG-HARGLHAWQINWPARQRGTHAVVGVA 118

  Fly   114 TESVNLGQFKFHFVSALGTNAQSWGFSYS-GRIQHCGELLP---Y------GQKFSQGCLIGVCL 168
            |....|  ....:.:.:|::|:|||:... .|:.|.|:..|   |      .:.|:....:.|.|
Human   119 TARAPL--HSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVL 181

  Fly   169 DRTRGHLEFYLNRRSLGVAYTNVPTDPDVKIYPMVCST--AAKSVIRLIN-CTSQPVTL------ 224
            |...|.|.|.::.:.||||:..:   ...|:||:|.:.  ..:..:|.|| ...:|:.|
Human   182 DMDEGTLSFIVDGQYLGVAFRGL---KGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRR 243

  Fly   225 QLRSFQALSRQPLKLAELRQMP---GLKGIMQ 253
            .:||  ||.||  :|.::..:|   .||..:|
Human   244 SIRS--ALGRQ--RLQDISSLPLPQSLKNYLQ 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10516	NP_648819.2	SPRY_SOCS3	51..233	CDD:293936	53/202 (26%)
SPSB4	NP_543138.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		SPRY_SOCS1-2-4	54..227	CDD:293963	46/177 (26%)
		SOCS	232..273	CDD:383010	13/44 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810