DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10516 and SPSB2

DIOPT Version :9

Sequence 1:	NP_648819.2	Gene:	CG10516 / 39738	FlyBaseID:	FBgn0036549	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001139788.1	Gene:	SPSB2 / 84727	HGNCID:	29522	Length:	263	Species:	Homo sapiens

Alignment Length:	234	Identity:	55/234 - (23%)
Similarity:	92/234 - (39%)	Gaps:	48/234 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QEACNPGFCDCPFPNSIEVTNHKGHIPDLVRCQCGEDE-----SGNVNAWR---WHATDESDAV- 62
            |.|...|....|.|.::        .||| .|..|.:|     ..::.|.|   |:..|.|:.:
Human     3 QTALAGGSSSTPTPQAL--------YPDL-SCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIE 58

  Fly    63 VTDRDIIF--HPTYSQGTAIVRGEQALKTNMVHFWEMRVITTLAGTDVMFGIGTESVNLGQFKFH 125
            |.:..:.|  .|. :|.|...||::.....: |.||:.......||..:.|:.|....|.  ..|
Human    59 VKEGGLYFERRPV-AQSTDGARGKRGYSRGL-HAWEISWPLEQRGTHAVVGVATALAPLQ--TDH 119

  Fly   126 FVSALGTNAQSWGFSYS-GRIQH--------------CGELLPYGQKFSQGCLIGVCLDRTRGHL 175
            :.:.||:|::|||:... |::.|              .||.|...::      :.|.||...|.|
Human   120 YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPER------LLVVLDMEEGTL 178

  Fly   176 EFYLNRRSLGVAYTNVPTDPDVKIYPMVCSTAAKSVIRL 214
            .:.:....||.|:..:   ....:||.|.:...:..:|:
Human   179 GYAIGGTYLGPAFRGL---KGRTLYPAVSAVWGQCQVRI 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10516	NP_648819.2	SPRY_SOCS3	51..233	CDD:293936	43/185 (23%)
SPSB2	NP_001139788.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		13/53 (25%)
		SPRY_SOCS1-2-4	46..217	CDD:293963	42/182 (23%)
		SOCS_SSB2	222..263	CDD:239689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810