DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and BRR2

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_011099.1	Gene:	BRR2 / 856919	SGDID:	S000000974	Length:	2163	Species:	Saccharomyces cerevisiae

Alignment Length:	2200	Identity:	882/2200 - (40%)
Similarity:	1314/2200 - (59%)	Gaps:	134/2200 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YEYKANSNLVLQADVRLI---ERPRRDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTEERKVKRQ 72
            |.|...||.||:.|.|.:   :.|:||....:..|:.|::....||........:..:|..|..:
Yeast    17 YRYDEMSNKVLKVDKRFMNTSQNPQRDAEISQPKSMSGRISAKDMGQGLCNNINKGLKENDVAVE 81

  Fly    73 KRDEAQYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQEALG-DQPRDILCGAA 136
            |..::....:..:..|:|:...|  ..:.|.||.....:|||.:|.::.|.|| |.|.|::.|.|
Yeast    82 KTGKSASLKKIQQHNTILNSSSD--FRLHYYPKDPSNVETYEQILQWVTEVLGNDIPHDLIIGTA 144

  Fly   137 DEILAVLK-NDRLKD---RERKKDIDSLLGAVTDE-RFALLVNLGKKITDFGSDAVNA---LTAA 193
            |..:..|| |:..:|   .|||:.|...||...|. :|..||.|.|.|||:.:...|:   ..|.
Yeast   145 DIFIRQLKENEENEDGNIEERKEKIQHELGINIDSLKFNELVKLMKNITDYETHPDNSNKQAVAI 209

  Fly   194 PNNEEQIDETYGINVQFEESEEESDND--MYGEIRDDDAQDEGEEARIDHTLHAENLANEEAANN 256
            ..::|:.||        ||..|.|:|.  :.|||.|:  :|:.||...:.........|:.|..|
Yeast   210 LADDEKSDE--------EEVTEMSNNANVLGGEINDN--EDDDEEYDYNDVEVNSKKKNKRALPN 264

  Fly   257 VKKE------------RSLHPLDIDAYWLQRCLSK--FYKDAMVSQSKAADVLKILKDAA----D 303
            ::.:            .|:....||.::|||.|..  .|||..|.|..:.   |||.|..    :
Yeast   265 IENDIIKLSDSKTSNIESVPIYSIDEFFLQRKLRSELGYKDTSVIQDLSE---KILNDIETLEHN 326

  Fly   304 DRDCENQLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRIREKM--RGNSALAK--- 363
            ....|.:||.||.::.....:.:..||..:.:...||.: |::|...:.|||  :|.:.|.:
Yeast   327 PVALEQKLVDLLKFENISLAEFILKNRSTIFWGIRLAKS-TENEIPNLIEKMVAKGLNDLVEQYK 390

  Fly   364 ------ILRQLDTGKSEDQEEGEARGSKRGKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHF 422
                  ..|:||:|..:.| ..||:.:|...              ..:..:::||::.|.:.|..
Yeast   391 FRETTHSKRELDSGDDQPQ-SSEAKRTKFSN--------------PAIPPVIDLEKIKFDESSKL 440

  Fly   423 MANKRCQLPDGSYRKQRKGYEEVHVPA-LKPVPFDANEELQPVDKLPKYVQPVFEGFKT--LNRI 484
            |...:..||:||:::.:..|:|:|:|| .|||   .:.||:.:..||.:.|..|...:|  ||.|
Yeast   441 MTVTKVSLPEGSFKRVKPQYDEIHIPAPSKPV---IDYELKEITSLPDWCQEAFPSSETTSLNPI 502

  Fly   485 QSRLYKAALDSDENMLLCAPTGAGKTNVALLTMMREIGKHIN-EDGTINAQDFKIIYVAPMKSLV 548
            ||:::.||.:.|.|||:|||||:||||:||||:::.:..|.| :...:|...|||:|:||:|:||
Yeast   503 QSKVFHAAFEGDSNMLICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALV 567

  Fly   549 QEMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVI 613
            ||.|..|.||||...:.|:|||||.:|:|:||..|||:|.|||||||.||.......|.||||:|
Yeast   568 QEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLI 632

  Fly   614 IDEIHLLHDERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDN 678
            |||||||||:||||||::||||....:..||..|::|||||||||:||..|||| |.:||||||:
Yeast   633 IDEIHLLHDDRGPVLESIVARTFWASKYGQEYPRIIGLSATLPNYEDVGRFLRV-PKEGLFYFDS 696

  Fly   679 SYRPVSLEQQYIGVTEKKALKRFQVMNEIVYEKTMEHAGR-NQVLVFVHSRKETGKTARAVRDMC 742
            |:||..|.||:.|:.|:.:||:.:.||:..|||.:|.... ||::|||||||||.:||..:::..
Yeast   697 SFRPCPLSQQFCGIKERNSLKKLKAMNDACYEKVLESINEGNQIIVFVHSRKETSRTATWLKNKF 761

  Fly   743 LEQDTLGSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQ 807
            .|::......|..:.|.::|:|||..|.:..|::|:..|...||||:||.||:|.||||||..:|
Yeast   762 AEENITHKLTKNDAGSKQILKTEAANVLDPSLRKLIESGIGTHHAGLTRSDRSLSEDLFADGLLQ 826

  Fly   808 VLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITN 872
            |||.||||||||||||||||||||.||:||||.|.:||..||||||||||||:|||.||||:||:
Yeast   827 VLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQMLGRAGRPRYDTFGEGIIITD 891

  Fly   873 HSELQFYLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYG 937
            .|.:|:|||:|||||||||||:|||.|.||||:|.|.::...||||||.|||||:|||.:|.||.
Yeast   892 QSNVQYYLSVLNQQLPIESQFVSKLVDNLNAEVVAGNIKCRNDAVNWLAYTYLYVRMLASPMLYK 956

  Fly   938 VSHDAIKADPLLEQHRADLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYN 1002
            |..  |.:|..|::.|..|:|:|.|.|:...|:.||.:....:.||||.|||.:|:.|.:|..||
Yeast   957 VPD--ISSDGQLKKFRESLVHSALCILKEQELVLYDAENDVIEATDLGNIASSFYINHASMDVYN 1019

  Fly  1003 QLLKQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYI 1067
            :.|.:..::|:|||:||:|.||:::|||.|||.||::|:|:.||||:|.|::..||||||||:|.
Yeast  1020 RELDEHTTQIDLFRIFSMSEEFKYVSVRYEEKRELKQLLEKAPIPIREDIDDPLAKVNVLLQSYF 1084

  Fly  1068 SQLKLEGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQF 1132
            ||||.|||||.||:|||.|:|.||:||:|||.|.|||.......|.|||....:||.:..|||||
Yeast  1085 SQLKFEGFALNSDIVFIHQNAGRLLRAMFEICLKRGWGHPTRMLLNLCKSATTKMWPTNCPLRQF 1149

  Fly  1133 KKMPDEIAKKLEKKHFPWGRLYDLE-PHELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRG 1196
            |..|.|:.|:||....|||....|| |.|:|..||..|.||.::..:.:|||:.::.:.|||||.
Yeast  1150 KTCPVEVIKRLEASTVPWGDYLQLETPAEVGRAIRSEKYGKQVYDLLKRFPKMSVTCNAQPITRS 1214

  Fly  1197 TLRVELTITPDFQWDEKVHGQSEGFWVLIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFE- 1260
            .:|..:.|..|:.||..|||..|.|.:::||.|.:.||:::...:.......|..|.|...:.:
Yeast  1215 VMRFNIEIIADWIWDMNVHGSLEPFLLMLEDTDGDSILYYDVLFITPDIVGHEFTLSFTYELKQH 1279

  Fly  1261 ---PLPPQYFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQPLPISALRQPKFESFYS 1322
               .|||.:||.::|:.|..:|.::||||....||:|..|||.||:...:..|.|....|...:
Yeast  1280 NQNNLPPNFFLTLISENWWHSEFEIPVSFNGFKLPKKFPPPTPLLENISISTSELGNDDFSEVF- 1343

  Fly  1323 QRFPQFNPIQTQVFNAVYNSDENVFVGAPTGSGKMTIAEFAIMRLFTTQSDARCVYLVSEEALAD 1387
             .|..||.||:|||.::|||:::||||:..|:||..:||.|::..: .|:..|.||:.......|
Yeast  1344 -EFKTFNKIQSQVFESLYNSNDSVFVGSGKGTGKTAMAELALLNHW-RQNKGRAVYINPSGEKID 1406

  Fly  1388 LVFADWHSKFGSL-DIKVV-KLTGETGTDLKLIAKGQLVITTADKWDVLSRRWKQRKNVQLVNLF 1450
            .:.:||:.:|..| ..|:: ||..:...:|||:||..:::.|..::::|||||:||||:|.:.|.
Yeast  1407 FLLSDWNKRFSHLAGGKIINKLGNDPSLNLKLLAKSHVLLATPVQFELLSRRWRQRKNIQSLELM 1471

  Fly  1451 IVDEL-QLVGGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQWLGCNPNATFNFH 1514
            |.|:. ::..|..|.|.|.:.|||.:|::|:||:||.|.||..|.:|||..:|.|...:..:||.
Yeast  1472 IYDDAHEISQGVYGAVYETLISRMIFIATQLEKKIRFVCLSNCLANARDFGEWAGMTKSNIYNFS 1536

  Fly  1515 PSVRPIPLELHIQGYNVTHNATRIATMSKPVYNAILKYSAHK-PVIVFVSSRKQARLTAIDVLTY 1578
            ||.|..|||::||.:....:.:...:|.:..:.|....:.:: ...||:.|||       |.:..
Yeast  1537 PSERIEPLEINIQSFKDVEHISFNFSMLQMAFEASAAAAGNRNSSSVFLPSRK-------DCMEV 1594

  Fly  1579 AASDLQPNR-----FFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEGLSASDHRLVEQLFDSG 1638
            |::.::.::     ..:.|||.|.|::|::||..|:..|..||..|::|::::|.|:|::|::.|
Yeast  1595 ASAFMKFSKAIEWDMLNVEEEQIVPYIEKLTDGHLRAPLKHGVGILYKGMASNDERIVKRLYEYG 1659

  Fly  1639 AVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMIGRANRPNEDADAKCVL 1703
            ||.|.:||:| |...:.....|||:.|..|:|..|.|..|.|.::|:|:|.|: .|:....|.::
Yeast  1660 AVSVLLISKD-CSAFACKTDEVIILGTNLYDGAEHKYMPYTINELLEMVGLAS-GNDSMAGKVLI 1722

  Fly  1704 MCQSSKKDFFKKFINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRLTQNPN 1768
            :...:.|.::|||:.||||.||:|.:.:||..|.|:....|::|||.||:.|:::.|||:..||:
Yeast  1723 LTSHNMKAYYKKFLIEPLPTESYLQYIIHDTLNNEIANSIIQSKQDCVDWFTYSYFYRRIHVNPS 1787

  Fly  1769 YYNLQGVTHRHLSDHLSELVENTLSDLEQSKCISVE-------------DDMDT---LPLNLGMI 1817
            ||.::..:...:|..||.|||..|:||.:|..|.::             ||..|   ..|:.|:|
Yeast  1788 YYGVRDTSPHGISVFLSNLVETCLNDLVESSFIEIDDTEAEVTAEVNGGDDEATEIISTLSNGLI 1852

  Fly  1818 AAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTGPN 1882
            |::|.:::.||:.|..||::.:.::.:|.::|:|.|:|.|.:|..:..:|..||:|||  |..|.
Yeast  1853 ASHYGVSFFTIQSFVSSLSNTSTLKNMLYVLSTAVEFESVPLRKGDRALLVKLSKRLP--LRFPE 1915

  Fly  1883 ETAPKFNDPHIKTNLLLQAHLSRLQLGPELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVAAM 1947
            .|:.  .....|..|||||:.|||:|..:.|.|.:.||.|.:.||...||:||:||:|: |..||
Yeast  1916 HTSS--GSVSFKVFLLLQAYFSRLELPVDFQNDLKDILEKVVPLINVVVDILSANGYLN-ATTAM 1977

  Fly  1948 ELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKKIETVFDIMELEDEDRTRLLQLSDLQMADVA 2012
            :||||:.|.:|..|:.|:|:|||:.:|:::|.|..:|||:|||.||||:|..:|.|:|.|:|.||
Yeast  1978 DLAQMLIQGVWDVDNPLRQIPHFNNKILEKCKEINVETVYDIMALEDEERDEILTLTDSQLAQVA 2042

  Fly  2013 RFCNRYPNIELNYEVVDKDRINSGSTVNVVVQLEREDEVTG-PVIAPFFPQKREEGWWVVIGDPK 2076
            .|.|.|||:||.|.:.:.|.:.||....:.:||.|:.|... .|.:..:|..:.|.||:|:|:..
Yeast  2043 AFVNNYPNVELTYSLNNSDSLISGVKQKITIQLTRDVEPENLQVTSEKYPFDKLESWWLVLGEVS 2107

  Fly  2077 TNSLLSIKRLTLQQKA-KVKLDFVAPSPGKHDYTLYYMSDSYLGCDQEYKFSIEV 2130
            ...|.:||::||.::. :.:|:|..|:.|||:.|::.:.||||..|:|..|.|.|
Yeast  2108 KKELYAIKKVTLNKETQQYELEFDTPTSGKHNLTIWCVCDSYLDADKELSFEINV 2162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	414/779 (53%)
		DEAD	482..661	CDD:278688	103/179 (58%)
		HELICc	773..859	CDD:197757	61/85 (72%)
		Sec63	982..1285	CDD:280962	139/307 (45%)
		DEXDc	1320..1506	CDD:214692	74/188 (39%)
		DEAD	1329..1495	CDD:278688	67/168 (40%)
		HELICc	1615..1694	CDD:197757	30/78 (38%)
		Sec63	1811..2127	CDD:280962	126/317 (40%)
BRR2	NP_011099.1	Helicase_PWI	281..389	CDD:407980	32/111 (29%)
		BRR2	462..1263	CDD:224125	423/806 (52%)
		BRR2	1314..>1953	CDD:224125	228/654 (35%)
		DEXHc_Brr2_2	1345..1536	CDD:350779	75/191 (39%)
		SEC63	1843..2161	CDD:214744	127/322 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	1460	1.000	Inparanoid score	I11
Isobase	1	0.950	-	0	Normalized mean entropy	S560
OMA	1	1.010	-	-		QHG54133
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto99279
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R148
SonicParanoid	1	1.000	-	-		X2806
TreeFam	1	0.960	-	-
	15	14.810