DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and HFM1

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_011263.2	Gene:	HFM1 / 852641	SGDID:	S000003220	Length:	1187	Species:	Saccharomyces cerevisiae

Alignment Length:	1022	Identity:	275/1022 - (26%)
Similarity:	449/1022 - (43%)	Gaps:	194/1022 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 EEGEARGSKRGKG----DAEDGGAAAAGQVAGVRQLL--ELEEMAFTQGSHFMANKRCQLPDGSY 435
            :|.|......|:|    |.:|..:..|.......:|.  :||                |.||...
Yeast    57 DENETEEIFEGRGLQFFDKDDNFSITADDTQVTSKLFDHDLE----------------QTPDEEA 105

  Fly   436 RKQRKGYEEVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENML 500
            :|.:|      |...|     :.::......||...:.||: |...|::||..:.:..:|:||.:
Yeast   106 KKPKK------VTIRK-----SAKKCLSTTILPDSFRGVFK-FTEFNKMQSEAFPSIYESNENCI 158

  Fly   501 LCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLT 565
            :.:|||:|||.:..|.::|.| |..|.|    ..:.||||:||.|||..||..|:.....  ||:
Yeast   159 ISSPTGSGKTVLFELAILRLI-KETNSD----TNNTKIIYIAPTKSLCYEMYKNWFPSFV--NLS 216

  Fly   566 VSELTGDHQ-LTREQIAATQVIVCTPEKWDIITRKGGE--RTFVSLVRLVIIDEIHLLHDERGPV 627
            |..||.|.. |..|:.....:|:.||||||::||:..:  |.| .||:||::||||.:.::||..
Yeast   217 VGMLTSDTSFLETEKAKKCNIIITTPEKWDLLTRRWSDYSRLF-ELVKLVLVDEIHTIKEKRGAS 280

  Fly   628 LEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPD--KGLFYFDNSYRPVSLEQQYI 690
            ||.::.|    :.|..:.:|.|.||||:||.:|:|.:|:...:  ..:..||.|||.|.|.:...
Yeast   281 LEVILTR----MNTMCQNIRFVALSATVPNIEDLALWLKTNNELPANILSFDESYRQVQLTKFVY 341

  Fly   691 GVTE--KKALKRFQVMNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLK 753
            |.:.  |...::..:.|..:.|...:||....||:|..:|..|..||:              ||.
Yeast   342 GYSFNCKNDFQKDAIYNSKLIEIIEKHADNRPVLIFCPTRASTISTAK--------------FLL 392

  Fly   754 EGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWG 818
            ......:..:.......:..|.|.:..|.|.||||::..|||.||..|....|.:|.||:|||.|
Yeast   393 NNHIFSKSKKRCNHNPSDKILNECMQQGIAFHHAGISLEDRTAVEKEFLAGSINILCSTSTLAVG 457

  Fly   819 VNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLL 883
            |||||:.||||||:.:|..:.:  |.|.||||||:|||||||::|.|..:::|:....|.|.:|:
Yeast   458 VNLPAYLVIIKGTKSWNSSEIQ--EYSDLDVLQMIGRAGRPQFETHGCAVIMTDSKMKQTYENLI 520

  Fly   884 NQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYG-----VSHDAI 943
            :....:||.....|.:.|.||..|.||..::.|||||..|:.|:|..:||..|.     ||..::
Yeast   521 HGTDVLESSLHLNLIEHLAAETSLETVYSIETAVNWLRNTFFYVRFGKNPAAYQEVNRYVSFHSV 585

  Fly   944 KADPLLEQHRADLLHTAACCLERSGLIK---YDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLL 1005
            : |..:.|....||.|         |:|   .|...|.::.|..|...:.:|::.|:|..:.. .
Yeast   586 E-DSQINQFCQYLLDT---------LVKVKIIDISNGEYKSTAYGNAMTRHYISFESMKQFIN-A 639

  Fly  1006 KQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPI-PI---------KES--IEEHSAK 1058
            |:.||...:..:.:.|.||..:.||..||    ||.:.:.: |:         |:|  |:..|.|
Yeast   640 KKFLSLQGILNLLATSEEFSVMRVRHNEK----KLFKEINLSPLLKYPFLTEKKQSQIIDRVSQK 700

  Fly  1059 VNVLLQAYISQLKLEGF--------ALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLC 1115
            |::|:|..:..|:...:        .|:.|...:.:...||::.:.:..:.:........||.|.
Yeast   701 VSLLIQYELGGLEFPSYEGASKLHQTLVQDKFLVFRHCFRLLKCMVDTFIEKSDGTSLKNTLFLL 765

  Fly  1116 KMIDRRMWQSMTP--LRQFKKMPDEIAKKLEKKHFPWGRLYDLEPHELGELIRVPKLGKTIHKFV 1178
            :.::...|:: ||  |||.|.:.....::|.:             |.:..|..:..|..|   .:
Yeast   766 RSLNGHCWEN-TPMVLRQLKTIGLVSVRRLIR-------------HGITNLEEMGHLSDT---QI 813

  Fly  1179 HQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHG---QSEGFWVLIEDVDSELILHHEFFL 1240
            ..:..|::...|:      ::.::::.|......|:..   ::|..|
Yeast   814 EYYLNLKIGNGIK------IKNDISLLPCLNIRTKLENCKIENEELW------------------ 854

  Fly  1241 LKQKYSQDEHQLKFFVPVFEPLPPQYFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQ 1305
                       |.|.|.:.....        |..|.|....|.:        |......||:|.:
Yeast   855 -----------LTFKVEISATFK--------SSIWHGQHLSLDI--------ETEKSSGELIDFR 892

  Fly  1306 PLPISALRQPKFESFYSQRFPQFNPIQTQVF---------NAVYNSD 1343
            .|.::.|:.|:.....::..|:...|:..:.         ..||::|
Yeast   893 RLQVNKLQSPRGFRISAKISPKLEKIEFSIHCQEIAGLGKTIVYSTD 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	239/814 (29%)
		DEAD	482..661	CDD:278688	71/181 (39%)
		HELICc	773..859	CDD:197757	46/85 (54%)
		Sec63	982..1285	CDD:280962	59/327 (18%)
		DEXDc	1320..1506	CDD:214692	5/33 (15%)
		DEAD	1329..1495	CDD:278688	4/24 (17%)
		HELICc	1615..1694	CDD:197757
		Sec63	1811..2127	CDD:280962
HFM1	NP_011263.2	BRR2	98..905	CDD:224125	261/945 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810