DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and emb1507

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_001185050.1	Gene:	emb1507 / 838690	AraportID:	AT1G20960	Length:	2171	Species:	Arabidopsis thaliana

Alignment Length:	2189	Identity:	1244/2189 - (56%)
Similarity:	1614/2189 - (73%)	Gaps:	79/2189 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADAAARQLQYEYKANSNLVLQADVRLIERPR-RDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTE 65
            |:|.||..||||:|||:|||..|    .||| ..|.|||..:|.||:|....|||..:.:|::.|
plant     8 AEAHARFKQYEYRANSSLVLTTD----NRPRDTHEPTGEPETLWGKIDPRSFGDRVAKGRPQELE 68

  Fly    66 E--RKVKRQKRDEA-------QYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQ 121
            :  :|.|:::||..       |....|::..::|::..|    .||:|||:|||..||.:|..||
plant    69 DKLKKSKKKERDVVDDMVNIRQSKRRRLREESVLTDTDD----AVYQPKTKETRAAYEAMLGLIQ 129

  Fly   122 EALGDQPRDILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDF--GS 184
            :.||.||..|:.|||||||||||||..::.|:|.:|:.||..:.:..|..||::||.||||  |.
plant   130 KQLGGQPPSIVSGAADEILAVLKNDAFRNPEKKMEIEKLLNKIENHEFDQLVSIGKLITDFQEGG 194

  Fly   185 DAVNALTAAPNNEEQIDETYGINVQFEESE---EESDNDMYGEIRDDDAQDEGEEARIDHTLHAE 246
            |:..   ...|::|.:|:..|:.|:|||:|   ||||.||   :.:||.:::.|..|.. .:..:
plant   195 DSGG---GRANDDEGLDDDLGVAVEFEENEEDDEESDPDM---VEEDDDEEDDEPTRTG-GMQVD 252

  Fly   247 NLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYK---DAMVSQSKAADVLKILKDAADDRDCE 308
            ...|:|.|.:..:..:|:..|||||||||.:|:.|:   |....|..|.::||||.: .|||..|
plant   253 AGINDEDAGDANEGTNLNVQDIDAYWLQRKISQAYEQQIDPQQCQVLAEELLKILAE-GDDRVVE 316

  Fly   309 NQLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRIREKMRG-NSALAKILRQLDTGK 372
            ::|::.|.|:.|..:|.|..||..|::||.||.|:...||.||.|:||| ...|..|:.||...:
plant   317 DKLLMHLQYEKFSLVKFLLRNRLKVVWCTRLARAEDQEERNRIEEEMRGLGPELTAIVEQLHATR 381

  Fly   373 --SEDQEEG-------EARGSK--------RGKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGS 420
              ::::||.       |||..|        ||:.|..|.. :.:|.|.|.||:|:||.:||.||.
plant   382 ATAKEREENLQKSINEEARRLKDETGGDGGRGRRDVADRD-SESGWVKGQRQMLDLESLAFDQGG 445

  Fly   421 HFMANKRCQLPDGSYRKQRKGYEEVHVP-ALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRI 484
            ..||||:|.||.||||...|||:||||| ..|.|  |.||:|..:.::|.:.||.|:|.:.|||:
plant   446 LLMANKKCDLPPGSYRSHGKGYDEVHVPWVSKKV--DRNEKLVKITEMPDWAQPAFKGMQQLNRV 508

  Fly   485 QSRLYKAALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQ 549
            ||::|..||...||:||||||||||||||:||:::::..:.|.|||.|..|:||:||||||:||.
plant   509 QSKVYDTALFKAENILLCAPTGAGKTNVAMLTILQQLEMNRNTDGTYNHGDYKIVYVAPMKALVA 573

  Fly   550 EMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVII 614
            |:|||...||..|.:.|.||:||..||..:|..||:||.|||||||||||.|:||:..||||:||
plant   574 EVVGNLSNRLKDYGVIVRELSGDQSLTGREIEETQIIVTTPEKWDIITRKSGDRTYTQLVRLLII 638

  Fly   615 DEIHLLHDERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNS 679
            ||||||||.||||||::||||:|.||||:|.:||||||||||||:|||.||||...||||.||.|
plant   639 DEIHLLHDNRGPVLESIVARTLRQIETTKENIRLVGLSATLPNYEDVALFLRVDLKKGLFKFDRS 703

  Fly   680 YRPVSLEQQYIGVTEKKALKRFQVMNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLE 744
            ||||.|.|||||::.||.|:|||:||::.|:|.:..||::|||:||||||||.|||||:||..:.
plant   704 YRPVPLHQQYIGISVKKPLQRFQLMNDLCYQKVLAGAGKHQVLIFVHSRKETSKTARAIRDTAMA 768

  Fly   745 QDTLGSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVL 809
            .|||..||||.|.:.:||.:..:.|||::||::|||||||||||::|.||.:||.||:..|:|||
plant   769 NDTLSRFLKEDSVTRDVLHSHEDIVKNSDLKDILPYGFAIHHAGLSRGDREIVETLFSQGHVQVL 833

  Fly   810 VSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHS 874
            ||||||||||||||||||||||||||||||.|:|||.|||:||||||||||||..||||:||.:|
plant   834 VSTATLAWGVNLPAHTVIIKGTQVYNPEKGAWMELSPLDVMQMLGRAGRPQYDQHGEGIIITGYS 898

  Fly   875 ELQFYLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVS 939
            |||:||||:|:||||||||||||.|.|||||||||||:.::|.:|||||||||||:|||||||::
plant   899 ELQYYLSLMNEQLPIESQFISKLADQLNAEIVLGTVQNAREACHWLGYTYLYIRMVRNPTLYGLA 963

  Fly   940 HDAIKADPLLEQHRADLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQL 1004
            .||:..|.:||:.||||:|:||..|:::.|:|||||:|:|||||||||||:||:||.|:.|||:.
plant   964 PDALAKDVVLEERRADLIHSAATILDKNNLVKYDRKSGYFQVTDLGRIASYYYITHGTIATYNEH 1028

  Fly  1005 LKQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYISQ 1069
            ||.|:.:|:|:|:||||.||::::||::||:||.||::||||||||::||.|||:||||||||||
plant  1029 LKPTMGDIDLYRLFSLSDEFKYVTVRQDEKMELAKLLDRVPIPIKETLEEPSAKINVLLQAYISQ 1093

  Fly  1070 LKLEGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKK 1134
            |||||.:|.||||:|||||.||:||::||||.|||||||:|.|.|.||:.:|||...||||||..
plant  1094 LKLEGLSLTSDMVYITQSAGRLVRALYEIVLKRGWAQLAEKALNLSKMVGKRMWSVQTPLRQFHG 1158

  Fly  1135 MPDEIAKKLEKKHFPWGRLYDLEPHELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLR 1199
            :.::|..:||||...|.|.|||...|||||||.||:||.:|||:|||||:.||.|:|||||..|.
plant  1159 LSNDILMQLEKKDLVWERYYDLSAQELGELIRSPKMGKPLHKFIHQFPKVTLSAHVQPITRTVLN 1223

  Fly  1200 VELTITPDFQWDEKVHGQSEGFWVLIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPP 1264
            ||||:||||.||||:|...|.||:::||.|.|.|||||:||||::|..::|.|.|.||:||||||
plant  1224 VELTVTPDFLWDEKIHKYVEPFWIIVEDNDGEKILHHEYFLLKKQYIDEDHTLHFTVPIFEPLPP 1288

  Fly  1265 QYFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFN 1329
            |||:|:|||:|:|:||.|||||||||||||..||||||||||||::|||.|.:|..| |.|..||
plant  1289 QYFVRVVSDKWLGSETVLPVSFRHLILPEKYPPPTELLDLQPLPVTALRNPNYEILY-QDFKHFN 1352

  Fly  1330 PIQTQVFNAVYNSDENVFVGAPTGSGKMTIAEFAIMRLFTTQSDA--RCVYLVSEEALADLVFAD 1392
            |:|||||..:||:::||.|.|||||||...|||||:|......||  |.||:...||:|...|..
plant  1353 PVQTQVFTVLYNTNDNVLVAAPTGSGKTICAEFAILRNHHEGPDATMRVVYIAPLEAIAKEQFRI 1417

  Fly  1393 WHSKFG-SLDIKVVKLTGETGTDLKLIAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQ 1456
            |..||| .|.::||:|||||..||||:.|||::|:|.:|||.|||||||||.||.|:|||||||.
plant  1418 WEGKFGKGLGLRVVELTGETALDLKLLEKGQIIISTPEKWDALSRRWKQRKYVQQVSLFIVDELH 1482

  Fly  1457 LVGGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIP 1521
            |:||:.|||||::.|||||||||:..:|||||||.||.:|:|:.:|:|.:.:..|||.|.|||:|
plant  1483 LIGGQHGPVLEVIVSRMRYISSQVINKIRIVALSTSLANAKDLGEWIGASSHGLFNFPPGVRPVP 1547

  Fly  1522 LELHIQGYNVTHNATRIATMSKPVYNAILKYSAH-KPVIVFVSSRKQARLTAIDVLTYAASD-LQ 1584
            ||:||||.:::....|:..|:||.|.||::::.: ||.||||.:||..||||:|::.|:..| .|
plant  1548 LEIHIQGVDISSFEARMQAMTKPTYTAIVQHAKNKKPAIVFVPTRKHVRLTAVDLMAYSHMDNPQ 1612

  Fly  1585 PNRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDL 1649
            ...|...:.|::.||:|::.::||||||..|:.|||||||:.|..:|.|||::|.:||.|:|..|
plant  1613 SPDFLLGKLEELDPFVEQIREETLKETLCHGIGYLHEGLSSLDQEIVTQLFEAGRIQVCVMSSSL 1677

  Fly  1650 CWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFK 1714
            |||..::||||::|.||:|:|:.:|:.|||:.|:|||:|||:||..|...|||:.|.:.:|:::|
plant  1678 CWGTPLTAHLVVVMGTQYYDGRENSHSDYPVPDLLQMMGRASRPLLDNAGKCVIFCHAPRKEYYK 1742

  Fly  1715 KFINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRH 1779
            ||:.|..|:||.|.|.:||:||||||...|||||||||||||||:||||.|||||||||||:|||
plant  1743 KFLYEAFPVESQLQHFLHDNFNAEVVAGVIENKQDAVDYLTWTFMYRRLPQNPNYYNLQGVSHRH 1807

  Fly  1780 LSDHLSELVENTLSDLEQSKCISVEDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGL 1844
            |||||||||||||||||.||||.|||:|:..||||||||:||||:|||||.||..|:||||::||
plant  1808 LSDHLSELVENTLSDLEASKCIEVEDEMELSPLNLGMIASYYYISYTTIERFSSLLSSKTKMKGL 1872

  Fly  1845 LEIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLG 1909
            |||::||:||:.:.:|..||..:|    ||.|......|. ||..|||:|.|.|||||.||..:|
plant  1873 LEILTSASEYDMIPIRPGEEDTVR----RLINHQRFSFEN-PKCTDPHVKANALLQAHFSRQNIG 1932

  Fly  1910 PELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFSPEI 1974
            ..|..|...:|..|.||:||.|||:||||||:.|:.|||::|||||.||.:||.|.|||||:.::
plant  1933 GNLAMDQRDVLLSATRLLQAMVDVISSNGWLNLALLAMEVSQMVTQGMWERDSMLLQLPHFTKDL 1997

  Fly  1975 VKRCTE---KKIETVFDIMELEDEDRTRLLQLSDLQMADVARFCNRYPNIELNYEVVDKDRINSG 2036
            .|||.|   |.||||||::|:|||:|..||::||.|:.|:||||||:|||:|.||:|..:.:|.|
plant  1998 AKRCQENPGKNIETVFDLVEMEDEERQELLKMSDAQLLDIARFCNRFPNIDLTYEIVGSEEVNPG 2062

  Fly  2037 STVNVVVQLEREDE---VTGPVIAPFFPQKREEGWWVVIGDPKTNSLLSIKRLTLQQKAKVKLDF 2098
            ..|.:.|.|||:.|   ..|||.:..:|:.:|||||:|:||.|||.||:|||::||:|.||||||
plant  2063 KEVTLQVMLERDMEGRTEVGPVDSLRYPKTKEEGWWLVVGDTKTNQLLAIKRVSLQRKVKVKLDF 2127

  Fly  2099 VAPS-PGKHDYTLYYMSDSYLGCDQEYKFSIEV-----GDFQSE 2136
            .||| ||:..||||:|.||||||||||.||::|     ||...|
plant  2128 TAPSEPGEKSYTLYFMCDSYLGCDQEYSFSVDVKGSGAGDRMEE 2171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	510/774 (66%)
		DEAD	482..661	CDD:278688	116/178 (65%)
		HELICc	773..859	CDD:197757	68/85 (80%)
		Sec63	982..1285	CDD:280962	195/302 (65%)
		DEXDc	1320..1506	CDD:214692	111/188 (59%)
		DEAD	1329..1495	CDD:278688	103/168 (61%)
		HELICc	1615..1694	CDD:197757	43/78 (55%)
		Sec63	1811..2127	CDD:280962	184/322 (57%)
emb1507	NP_001185050.1	BRR2	469..1265	CDD:224125	521/797 (65%)
		DEAD	506..685	CDD:278688	116/178 (65%)
		HELICc	802..883	CDD:197757	66/80 (83%)
		Sec63	1006..1309	CDD:280962	195/302 (65%)
		DEXDc	1348..1547	CDD:214692	116/198 (59%)
		DEAD	1352..1525	CDD:278688	104/172 (60%)
		HELICc	1572..1732	CDD:238034	78/159 (49%)
		SEC63	1836..2159	CDD:214744	186/327 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	425	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	2194	1.000	Inparanoid score	I2
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		otm2764
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2806
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840