DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)72Ab and AT2G42270

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_181756.1	Gene:	AT2G42270 / 818828	AraportID:	AT2G42270	Length:	2172	Species:	Arabidopsis thaliana

Alignment Length:	2187	Identity:	1185/2187 - (54%)
Similarity:	1587/2187 - (72%)	Gaps:	72/2187 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADAAARQLQYEYKANSNLVLQADVRLIERPRRD--EATGEVCSLVGKLDGTRMGDRYQRTKPEKT 64
            |:..||..||.||.||:|||.:|.|     |||  |::||..||.|::|....|||..|.:|.:.
plant     9 AEEQARLKQYGYKVNSSLVLNSDER-----RRDTHESSGEPESLRGRIDPKSFGDRVVRGRPHEL 68

  Fly    65 EERKVKRQKRDEAQYDF--------ERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQ 121
            :||..|.:|:.|...|.        .|::..::|::..|.    ||:|||:|||..:|::|..||
plant    69 DERLNKSKKKKERCDDLVSARESKRVRLREVSVLNDTEDG----VYQPKTKETRVAFEIMLGLIQ 129

  Fly   122 EALGDQPRDILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDF--GS 184
            :.||.||.||:|||||||||||||:.:|:.|:|.:|:.||..:||:.|:..|::||.|||:  |.
plant   130 QQLGGQPLDIVCGAADEILAVLKNESVKNHEKKVEIEKLLNVITDQVFSQFVSIGKLITDYEEGG 194

  Fly   185 DAVNALTAAPNNEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQDEGEEARIDHT--LHAEN 247
            |   :|:...:.:..:|...|:.::.||.::|||.||..:.:|::.:|..|   ::.|  :....
plant   195 D---SLSGKASEDGGLDYDIGVALECEEDDDESDLDMVQDEKDEEDEDVVE---LNKTGVVQVGV 253

  Fly   248 LANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYK---DAMVSQSKAADVLKILKDAADDRDCEN 309
            ..|.|.|...|::.||:.||||||||||.:|:.|:   ||...|..|.::||||.: .:|||.|.
plant   254 AINGEDARQAKEDTSLNVLDIDAYWLQRKISQEYEQKIDAQECQELAEELLKILAE-GNDRDVEI 317

  Fly   310 QLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRIREKMRG-NSALAKILRQLDTGKS 373
            :|:..|.::.|..:|.|..||..|::||.||..:...||.:|.|:|.| .|.||.|:::|...::
plant   318 KLLEHLQFEKFSLVKFLLQNRLKVVWCTRLARGRDQEERNQIEEEMLGLGSELAAIVKELHAKRA 382

  Fly   374 EDQEEGEAR------------------GSKRGKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGS 420
            ..:|..|.|                  ...||..|.:|.. ...|.:.|.||:::||.:||.||.
plant   383 TAKEREEKREKDIKEEAQHLMDDDSGVDGDRGMRDVDDLD-LENGWLKGQRQVMDLESLAFNQGG 446

  Fly   421 HFMANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQ 485
            ....|.:|:|||.|:|.:.|.::|||||.:.. .||:||:|..:..||::.||.|.|.:.|||:|
plant   447 FTRENNKCELPDRSFRIRGKEFDEVHVPWVSK-KFDSNEKLVKISDLPEWAQPAFRGMQQLNRVQ 510

  Fly   486 SRLYKAALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQE 550
            |::|..||...:|:||||||||||||||:||::.::|.::|..||.|..::||:||||||:||.|
plant   511 SKVYGTALFKADNILLCAPTGAGKTNVAVLTILHQLGLNMNPGGTFNHGNYKIVYVAPMKALVAE 575

  Fly   551 MVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIID 615
            :|.:..:||..:.:||.||:||..||.::|..||:||.|||||||||||.|:||:..||||:|||
plant   576 VVDSLSQRLKDFGVTVKELSGDQSLTGQEIKETQIIVTTPEKWDIITRKSGDRTYTQLVRLLIID 640

  Fly   616 EIHLLHDERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSY 680
            |||||.|.||||||::||||:|.||:|:|.:|||||||||||..|||:||||....|||.||.||
plant   641 EIHLLDDNRGPVLESIVARTLRQIESTKEHIRLVGLSATLPNCDDVASFLRVDLKNGLFIFDRSY 705

  Fly   681 RPVSLEQQYIGVTEKKALKRFQVMNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQ 745
            |||.|.|||||:..||.|:|||:||:|.|:|.:..||::|||:||||||||.|||||:||..:..
plant   706 RPVPLGQQYIGINVKKPLRRFQLMNDICYQKVVAVAGKHQVLIFVHSRKETAKTARAIRDTAMAN 770

  Fly   746 DTLGSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLV 810
            |||..||||.|.|.|:|:..|..:||.:|||||||||||||||:||.||.:||:.|...::|||:
plant   771 DTLSRFLKEDSQSREILKCLAGLLKNNDLKELLPYGFAIHHAGLTRTDREIVENQFRWGNLQVLI 835

  Fly   811 STATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSE 875
            |||||||||||||||||||||||||||:|.|:|||.|||:||:|||||||||.:||||:||.:|:
plant   836 STATLAWGVNLPAHTVIIKGTQVYNPERGEWMELSPLDVMQMIGRAGRPQYDQQGEGIIITGYSK 900

  Fly   876 LQFYLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSH 940
            ||:||.|:|:||||||||||||.|.|||||||||:|:.::|.:||||||||:||:|||||||||.
plant   901 LQYYLRLMNEQLPIESQFISKLADQLNAEIVLGTIQNAREACHWLGYTYLYVRMVRNPTLYGVSP 965

  Fly   941 DAIKADPLLEQHRADLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLL 1005
            ||:..|.|||:.||||:|:||..|:::.|||||||:|||||||||||||:||::|.|:..||:.|
plant   966 DALAKDLLLEERRADLIHSAATILDKNNLIKYDRKSGHFQVTDLGRIASYYYISHGTIAAYNENL 1030

  Fly  1006 KQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYISQL 1070
            |.|:::|||.|:||||.||::::||::||:||.||::|||||:||::|:.|||:|||||.|||:|
plant  1031 KPTMNDIELCRLFSLSEEFKYVTVRQDEKMELAKLLDRVPIPVKETLEDPSAKINVLLQVYISKL 1095

  Fly  1071 KLEGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKM 1135
            ||||.:|.||||:|||||.||:||||||||.||||||:.|.|.|.||:.:|||...|||.||..:
plant  1096 KLEGLSLTSDMVYITQSAGRLLRAIFEIVLKRGWAQLSQKALNLSKMVGKRMWSVQTPLWQFPGI 1160

  Fly  1136 PDEIAKKLEKKHFPWGRLYDLEPHELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRV 1200
            |.||..||||....|.|.|||...||||||..||:|:.:||::||||||:|:.|:|||:|..|:|
plant  1161 PKEILMKLEKNDLVWERYYDLSSQELGELICNPKMGRPLHKYIHQFPKLKLAAHVQPISRSVLQV 1225

  Fly  1201 ELTITPDFQWDEKVHGQSEGFWVLIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPPQ 1265
            |||:||||.||:|.:...|.||:::||.|.|.|||||:||.|::...::|.|.|.||:.||:|||
plant  1226 ELTVTPDFHWDDKANKYVEPFWIIVEDNDGEKILHHEYFLFKKRVIDEDHTLNFTVPISEPIPPQ 1290

  Fly  1266 YFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFNP 1330
            ||:|:|||:|:.:.|.|||||||||||||..||||||||||||:.|||.|.:|:.| |.|..|||
plant  1291 YFIRVVSDKWLDSPTVLPVSFRHLILPEKYPPPTELLDLQPLPVMALRNPSYETLY-QDFKHFNP 1354

  Fly  1331 IQTQVFNAVYNSDENVFVGAPTGSGKMTIAEFAIMR--LFTTQSDARCVYLVSEEALADLVFADW 1393
            :|||||..:||:.:||.|.|||||||...|||||:|  |....|..|.||:...||:|...|.||
plant  1355 VQTQVFTVLYNTSDNVVVAAPTGSGKTICAEFAILRNHLEGPDSAMRVVYIAPLEAIAKEQFRDW 1419

  Fly  1394 HSKFG-SLDIKVVKLTGETGTDLKLIAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQL 1457
            ..||| .|.::||:|||||..||||:.|||::|:|.:|||.|||||||||.:|.|:|||||||.|
plant  1420 EKKFGKGLGLRVVELTGETLLDLKLLEKGQIIISTPEKWDALSRRWKQRKYIQQVSLFIVDELHL 1484

  Fly  1458 VGGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIPL 1522
            :||:.|.|||::.|||||||||:..:|||||||.||.:|:|:.:|:|.:....|||.|:|||:||
plant  1485 IGGQGGQVLEVIVSRMRYISSQVGNKIRIVALSTSLANAKDLGEWIGASSCGVFNFPPNVRPVPL 1549

  Fly  1523 ELHIQGYNVTHNATRIATMSKPVYNAILKYSAH-KPVIVFVSSRKQARLTAIDVLTYAASD-LQP 1585
            |:||.|.::.....|:..|:||.|.||::::.: ||.||||.:||..||||:|::.|:..| ::.
plant  1550 EIHIHGVDILSFEARMQAMTKPTYTAIVQHAKNKKPAIVFVPTRKHVRLTAVDLIAYSHMDNMKS 1614

  Fly  1586 NRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDLC 1650
            ..|.....|:::|||.::.::||||||..|:.|||||||..|..:|.|||::|.:||.|:|..||
plant  1615 PDFLLGNLEELEPFLIQICEETLKETLRHGIGYLHEGLSNLDQEIVTQLFEAGRIQVCVMSSSLC 1679

  Fly  1651 WGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKK 1715
            ||..:.||||::|.|.||:|:.:|:.||||:::|||:||.:||..|...|||:.|.:.:|:::||
plant  1680 WGTPLKAHLVVVMGTHFYDGRENSHSDYPISNLLQMMGRGSRPLLDDAGKCVIFCHAPRKEYYKK 1744

  Fly  1716 FINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHL 1780
            |:.|.||:||||.|.:||:||||||.:.|||||||||||||:|:||||.||||||||.||:||||
plant  1745 FLYEALPVESHLQHFLHDNFNAEVVARVIENKQDAVDYLTWSFMYRRLPQNPNYYNLLGVSHRHL 1809

  Fly  1781 SDHLSELVENTLSDLEQSKCISVEDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLL 1845
            ||||||||||||||||.||||.:::::|..||||||||:||||||||||.||..|.||||::|||
plant  1810 SDHLSELVENTLSDLEVSKCIEIDNELDLSPLNLGMIASYYYINYTTIERFSSLLASKTKMKGLL 1874

  Fly  1846 EIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLGP 1910
            ||::||:||:.:.:|..||..:|.|...  .:.:..|   |:..||.:||:.|||||.||.::..
plant  1875 EILTSASEYDLIPIRPGEEDAVRRLINH--QRFSFQN---PRCTDPRVKTSALLQAHFSRQKISG 1934

  Fly  1911 ELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFSPEIV 1975
            .|..|..::|..|.||:||.|||:||||.|:.|:.|||::|||||.||.:||.|.|||||:.::.
plant  1935 NLVMDQCEVLLSATRLLQAMVDVISSNGCLNLALLAMEVSQMVTQGMWDRDSMLLQLPHFTKDLA 1999

  Fly  1976 KRCTE---KKIETVFDIMELEDEDRTRLLQLSDLQMADVARFCNRYPNIELNYEVVDKDRINSGS 2037
            |||.|   ..|||:||::|:||:.|..|||:||.|:.|:||||||:|||:|.||:|..:.::.|.
plant  2000 KRCHENPGNNIETIFDLVEMEDDKRQELLQMSDAQLLDIARFCNRFPNIDLTYEIVGSNEVSPGK 2064

  Fly  2038 TVNVVVQLEREDE---VTGPVIAPFFPQKREEGWWVVIGDPKTNSLLSIKRLTLQQKAKVKLDFV 2099
            .:.:.|.|||:.|   ..|||.||.:|:.:|||||:|:|:.|||.|::|||::||:||:|||:|.
plant  2065 DITLQVLLERDMEGRTEVGPVDAPRYPKTKEEGWWLVVGEAKTNQLMAIKRISLQRKAQVKLEFA 2129

  Fly  2100 APS-PGKHDYTLYYMSDSYLGCDQEYKFSIEVGDFQSESESE 2140
            .|: .|:..||||:|.||||||||||.|:::|.|..:....|
plant  2130 VPTETGEKSYTLYFMCDSYLGCDQEYSFTVDVKDSDAADHME 2171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	495/774 (64%)
		DEAD	482..661	CDD:278688	109/178 (61%)
		HELICc	773..859	CDD:197757	66/85 (78%)
		Sec63	982..1285	CDD:280962	180/302 (60%)
		DEXDc	1320..1506	CDD:214692	110/188 (59%)
		DEAD	1329..1495	CDD:278688	102/168 (61%)
		HELICc	1615..1694	CDD:197757	42/78 (54%)
		Sec63	1811..2127	CDD:280962	171/322 (53%)
AT2G42270	NP_181756.1	BRR2	484..1270	CDD:224125	499/785 (64%)
		DEAD	507..686	CDD:278688	109/178 (61%)
		HELICc	790..884	CDD:197757	69/93 (74%)
		Sec63	1007..1310	CDD:280962	180/302 (60%)
		DEAD	1353..1526	CDD:278688	103/172 (60%)
		HELICc	1631..1722	CDD:197757	47/90 (52%)
		SEC63	1837..2160	CDD:214744	173/327 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	425	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	2194	1.000	Inparanoid score	I2
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		otm2764
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	O	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2806
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840