DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)72Ab and snrnp200

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_001116729.1	Gene:	snrnp200 / 799690	ZFINID:	ZDB-GENE-081105-64	Length:	2134	Species:	Danio rerio

Alignment Length:	2147	Identity:	1584/2147 - (73%)
Similarity:	1867/2147 - (86%)	Gaps:	18/2147 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAAARQLQYEYKANSNLVLQADVRLIERPRRDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTE 65
            |||..||.||||||||||||||||..||:|.||||.||||.||||||:||:||||.|||||:..|
Zfish     1 MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTKMGDRSQRTKPQMLE 65

  Fly    66 ERKVKRQKRDEAQYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQEALGDQPRD 130
            ||:.||:||||.::|..:|||.|||||||||||||||:|||:|||:|||:||||||.||||||||
Zfish    66 ERRAKRRKRDEDRHDINKMKGFTLLSEGIDEMVGIVYKPKTKETRETYEILLSFIQAALGDQPRD 130

  Fly   131 ILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDFGSDAVNALTAAPN 195
            ||||||||:|||||||:::|:||:::::.|||...|.|:.:||||||||:|:|.|     ....|
Zfish   131 ILCGAADEVLAVLKNDKMRDKERRREVEQLLGPTDDTRYHVLVNLGKKISDYGGD-----KELQN 190

  Fly   196 NEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQD-EGEEARIDHTLHAENLANEEAANNVKK 259
            .::.||||||:|||||..|||.|.|.|||:||:.:.| |||||....||.| ||.|.......||
Zfish   191 MDDNIDETYGVNVQFESDEEEGDEDQYGEVRDEGSDDSEGEEADESSTLTA-NLGNTGDVMMTKK 254

  Fly   260 ERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLKILKDAADDRDCENQLVLLLGYDCFDFIK 324
             :.|||.||||:||||.||:||.||:|||.||.:||:|||.|:|||:||||||||||::.|||||
Zfish   255 -KDLHPRDIDAFWLQRQLSRFYNDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIK 318

  Fly   325 QLKLNRQMVLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSED---QEEGEARGSKR 386
            .|:.:|:|:||||||||||:::|:::|..||..:..|:|:|.||...:.||   :|.......::
Zfish   319 VLRQHRRMILYCTMLASAQSEAEKEKIINKMEADQDLSKVLYQLQETEKEDIIREERSRRERMRK 383

  Fly   387 GKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANKRCQLPDGSYRKQRKGYEEVHVPALK 451
            .:.|..:......|:....||||:||::.|||||||||||||||||||:||||||||||||||||
Zfish   384 SRVDDLESMDIDHGESVSSRQLLDLEDLTFTQGSHFMANKRCQLPDGSFRKQRKGYEEVHVPALK 448

  Fly   452 PVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENMLLCAPTGAGKTNVALLT 516
            |.||...|.|..::|||||.|..|||||:||||||:|:|..:::|||:|:|||||||||||||:.
Zfish   449 PKPFGDEETLVGIEKLPKYAQAGFEGFKSLNRIQSKLFKTTMETDENLLVCAPTGAGKTNVALMA 513

  Fly   517 MMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQLTREQIA 581
            |:||||||||.|||||..||||||:|||:||||||||:||:|||.|.:.||||||||||.:|:|.
Zfish   514 MLREIGKHINMDGTINVADFKIIYIAPMRSLVQEMVGSFGKRLASYGIIVSELTGDHQLCKEEIN 578

  Fly   582 ATQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDERGPVLEALVARTIRNIETTQEEV 646
            |||:|||||||||||||||||||:..||||:||||||||||:||||||:|:||||||:|.|||:|
Zfish   579 ATQIIVCTPEKWDIITRKGGERTYTQLVRLIIIDEIHLLHDDRGPVLESLIARTIRNVELTQEDV 643

  Fly   647 RLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSLEQQYIGVTEKKALKRFQVMNEIVYEK 711
            ||:|||||||||:||||.|||.|.|||||||||:|||.|||.|:|:|||||:||||:||||||||
Zfish   644 RLIGLSATLPNYEDVATCLRVDPSKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEK 708

  Fly   712 TMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQVKNTELKE 776
            .|||||:|||||||||||||||||||:||||||:||||.||:|||||.|||||||||.||.|||:
Zfish   709 IMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKD 773

  Fly   777 LLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRW 841
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Zfish   774 LLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRW 838

  Fly   842 VELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFISKLPDMLNAEIV 906
            .||.|||:|||||||||||||:||||||||:|.|||:||||||||||||||.:.||.||||||||
Zfish   839 TELGALDILQMLGRAGRPQYDSKGEGILITSHGELQYYLSLLNQQLPIESQMVGKLADMLNAEIV 903

  Fly   907 LGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTAACCLERSGLIK 971
            ||.||:.:||||||||||||:||||||||||||||....|||||:.|.||:||||..||::.|:|
Zfish   904 LGNVQNAKDAVNWLGYTYLYVRMLRNPTLYGVSHDDRSIDPLLERRRMDLVHTAATVLEKNNLVK 968

  Fly   972 YDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLLKQTLSEIELFRVFSLSSEFRHISVREEEKLE 1036
            ||:::|.||||||||||||:|:|||:::|||||||.||||||||||||||||||:|:||||||||
Zfish   969 YDKRSGSFQVTDLGRIASHFYITHESIMTYNQLLKPTLSEIELFRVFSLSSEFRNITVREEEKLE 1033

  Fly  1037 LQKLMERVPIPIKESIEEHSAKVNVLLQAYISQLKLEGFALMSDMVFITQSAARLMRAIFEIVLT 1101
            ||||:||||||:||||||.|||:|||||||||||||||||||:|||::||||.|||||||||||:
Zfish  1034 LQKLLERVPIPVKESIEEPSAKINVLLQAYISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLS 1098

  Fly  1102 RGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPDEIAKKLEKKHFPWGRLYDLEPHELGELIR 1166
            ||||||.||||.||||||:||||||:|||||:|:|:|:.||:|||:||:.|||||..:|:|||||
Zfish  1099 RGWAQLTDKTLNLCKMIDKRMWQSMSPLRQFRKLPEEVIKKIEKKNFPFERLYDLNHNEIGELIR 1163

  Fly  1167 VPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHGQSEGFWVLIEDVDSE 1231
            :||:||||||:|||||||:|:.|:|||||.||:||||||||||||:|:||.||.||:|:||||||
Zfish  1164 MPKMGKTIHKYVHQFPKLDLAVHLQPITRSTLKVELTITPDFQWDDKIHGSSEAFWILVEDVDSE 1228

  Fly  1232 LILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPPQYFLRIVSDRWIGAETQLPVSFRHLILPEKNM 1296
            ::||||:||||.||:||||.:.||||||||||||||:||.||||:..||||||||||||||||..
Zfish  1229 VVLHHEYFLLKAKYAQDEHLVTFFVPVFEPLPPQYFIRIASDRWLSCETQLPVSFRHLILPEKYP 1293

  Fly  1297 PPTELLDLQPLPISALRQPKFESFYSQRFPQFNPIQTQVFNAVYNSDENVFVGAPTGSGKMTIAE 1361
            ||||||||||||:||||...|||.| |.||.||||||||||||||||:||||||||||||...||
Zfish  1294 PPTELLDLQPLPVSALRNGAFESLY-QNFPFFNPIQTQVFNAVYNSDDNVFVGAPTGSGKTICAE 1357

  Fly  1362 FAIMRLFTTQSDARCVYLVSEEALADLVFADWHSKF-GSLDIKVVKLTGETGTDLKLIAKGQLVI 1425
            |||:|:....::.||||:...||||:.||.|||.|| .:|:.|||.|||||.|||||:.||.:::
Zfish  1358 FAILRMLLHNAEGRCVYITPMEALAEQVFLDWHQKFQENLNKKVVLLTGETSTDLKLLGKGDIIV 1422

  Fly  1426 TTADKWDVLSRRWKQRKNVQLVNLFIVDELQLVGGEEGPVLEIVCSRMRYISSQIEKQIRIVALS 1490
            :|.||||:||||||||||||.|:|||:||:.|:||:.|||||::||||||||||||:.|||||||
Zfish  1423 STPDKWDILSRRWKQRKNVQNVSLFIIDEVHLIGGDNGPVLEVICSRMRYISSQIERPIRIVALS 1487

  Fly  1491 ASLTDARDVAQWLGCNPNATFNFHPSVRPIPLELHIQGYNVTHNATRIATMSKPVYNAILKYSAH 1555
            :||::|:|||.||||:..|||||||:|||:||||||||:||:|..||:.:|:||||:||:|:|..
Zfish  1488 SSLSNAKDVAHWLGCSTTATFNFHPNVRPVPLELHIQGFNVSHTQTRLLSMAKPVYHAIMKHSPS 1552

  Fly  1556 KPVIVFVSSRKQARLTAIDVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLH 1620
            |||:|||.||:|.||||||:||:.|:|:.|.||.|:.|:|:.||:|.::|.||||||:.||.|||
Zfish  1553 KPVLVFVPSRRQTRLTAIDILTFCAADVVPQRFLHSTEKDLVPFMENLSDVTLKETLSNGVGYLH 1617

  Fly  1621 EGLSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQ 1685
            ||||.::.|:||.||.|||:||.|.||.||||.:|||||||:||||:||||.|:|.||||.||||
Zfish  1618 EGLSPTERRIVEHLFTSGAIQVVVASRSLCWGTNISAHLVIVMDTQYYNGKIHAYVDYPIYDVLQ 1682

  Fly  1686 MIGRANRPNEDADAKCVLMCQSSKKDFFKKFINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDA 1750
            |:|:||||.:|.:.:||:|||.|||||||||:.||||:||||||.:|||||||:||||:||||||
Zfish  1683 MVGKANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCLHDHFNAEIVTKTVENKQDA 1747

  Fly  1751 VDYLTWTFLYRRLTQNPNYYNLQGVTHRHLSDHLSELVENTLSDLEQSKCISVEDDMDTLPLNLG 1815
            ||||||||||||:|||||||||||::||||||||||||||||.|||||||||:||:||..|||||
Zfish  1748 VDYLTWTFLYRRMTQNPNYYNLQGMSHRHLSDHLSELVENTLQDLEQSKCISIEDEMDVAPLNLG 1812

  Fly  1816 MIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTG 1880
            |||||||||||||||||:|||:|||||||:||||:||||:::.:||||:.:||.|:|::|:||..
Zfish  1813 MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYKNIPIRHHEDTLLRQLAQKVPHKLNN 1877

  Fly  1881 PNETAPKFNDPHIKTNLLLQAHLSRLQLGPELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVA 1945
                 |||||||:||||||||||||:||..|||.|||:|||||:|||||||||||||||||||:|
Zfish  1878 -----PKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAVRLIQACVDVLSSNGWLSPALA 1937

  Fly  1946 AMELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKKIETVFDIMELEDEDRTRLLQLSDLQMAD 2010
            |||||||||||||||||||:|||||:.|::||||:|.:|::|||||:||||||.||||||:|:||
Zfish  1938 AMELAQMVTQAMWSKDSYLRQLPHFTSELIKRCTDKGVESIFDIMEMEDEDRTGLLQLSDVQVAD 2002

  Fly  2011 VARFCNRYPNIELNYEVVDKDRINSGSTVNVVVQLEREDEVTGPVIAPFFPQKREEGWWVVIGDP 2075
            |||||||||||||:|||||||.|.|||.|.|.||||||:|||||||||.||||||||||||||||
Zfish  2003 VARFCNRYPNIELSYEVVDKDDIKSGSPVVVQVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDP 2067

  Fly  2076 KTNSLLSIKRLTLQQKAKVKLDFVAPSPGKHDYTLYYMSDSYLGCDQEYKFSIEVGDFQSESESE 2140
            |:|||:||||||||||||||||||||..|.|:||||:|||:|:|||||||||.||.:..||.:|:
Zfish  2068 KSNSLISIKRLTLQQKAKVKLDFVAPVVGVHNYTLYFMSDAYMGCDQEYKFSTEVKEADSEGDSD 2132

  Fly  2141 SD 2142
            ||
Zfish  2133 SD 2134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	623/774 (80%)
		DEAD	482..661	CDD:278688	138/178 (78%)
		HELICc	773..859	CDD:197757	80/85 (94%)
		Sec63	982..1285	CDD:280962	240/302 (79%)
		DEXDc	1320..1506	CDD:214692	128/186 (69%)
		DEAD	1329..1495	CDD:278688	116/166 (70%)
		HELICc	1615..1694	CDD:197757	56/78 (72%)
		Sec63	1811..2127	CDD:280962	252/315 (80%)
snrnp200	NP_001116729.1	BRR2	441..1238	CDD:224125	636/796 (80%)
		DEAD	479..658	CDD:278688	138/178 (78%)
		HELICc	681..867	CDD:238034	164/185 (89%)
		Sec63	979..1282	CDD:280962	240/302 (79%)
		DEAD	1325..1496	CDD:278688	117/170 (69%)
		HELICc	1604..1690	CDD:197757	61/85 (72%)
		SEC63	1805..2119	CDD:214744	253/318 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576397
Domainoid	1	1.000	525	1.000	Domainoid score	I279
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	3141	1.000	Inparanoid score	I13
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto38740
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R148
SonicParanoid	1	1.000	-	-		X2806
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800