DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(3)72Ab and DNApol-theta

DIOPT Version :9

Sequence 1:NP_648818.3 Gene:l(3)72Ab / 39737 FlyBaseID:FBgn0263599 Length:2142 Species:Drosophila melanogaster
Sequence 2:NP_524333.1 Gene:DNApol-theta / 41571 FlyBaseID:FBgn0002905 Length:2059 Species:Drosophila melanogaster


Alignment Length:2331 Identity:439/2331 - (18%)
Similarity:829/2331 - (35%) Gaps:771/2331 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 AQDEGEEARIDHTLHAE----NLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYKDAM---VS 287
            |.::|.:|  |...:|:    |:..:.|.|.|..|            :|...|:|::|..   |:
  Fly    16 ALEKGMQA--DDKENAQPGNGNIQVQSAGNEVNSE------------IQEINSEFFRDEFSYEVN 66

  Fly   288 QS-KAADVLKILKDAADDRDCENQLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRI 351
            |: |.|:     :...:....:..:.::...|..|..:...||.|:   ||..:....|:....:
  Fly    67 QAHKPAE-----QSVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQI---CTQSSFEGEDAGADAV 123

  Fly   352 REK--MRGNSALAKILRQLDTGKSEDQEEGEARGSKRGKGDAEDGGAAAAGQVAGVRQLLELEEM 414
            .::  :..||.|.         .::|:|     .|::.|.|.....:..|      :|....|..
  Fly   124 LDQPNLDENSFLC---------PAQDEE-----ASEQLKEDILHSHSVLA------KQEFYQEIS 168

  Fly   415 AFTQGSHFMANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVD--KLPKYVQPVFEG 477
            ..||....|:..:.::...|.|.:..      :|....:|.|.| .|:.:.  .||..:|..::.
  Fly   169 QVTQNLSSMSPNQLRVSPNSSRIREA------MPERPAMPLDLN-TLRSISAWNLPMSIQAEYKK 226

  Fly   478 FKTLNRIQSR---LYKAALDSDE-NMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKI 538
            ...::....:   |.|..|..:. |::..|||.||||.|:.:.|::          |:..:..|:
  Fly   227 KGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLK----------TVLERGKKV 281

  Fly   539 IYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGER 603
            :.:.|..|:|:|.:......|......|....|.: .......:..|.:||.||.:.|..|..|:
  Fly   282 LLILPFISVVREKMFYMQDLLTPAGYRVEGFYGGY-TPPGGFESLHVAICTIEKANSIVNKLMEQ 345

  Fly   604 TFVSLVRLVIIDEIHLLHDE-RGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRV 667
            ..:..:.:|::||:||:.|: ||.:||.|:|:.:........:::::.:||||.|.|.:.::|..
  Fly   346 GKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDA 410

  Fly   668 KPDKGLFYFDNSYRPVSLEQQYIGVTEKKALK--------RFQVMNEIVYEKTMEHAGRN----- 719
            :     .|..| ||||:|         |:.:|        |.:::.::..:|.:.....|     
  Fly   411 E-----LYITN-YRPVAL---------KEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLENDSDDV 460

  Fly   720 ------------QVLVFVHSR----KETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQ 768
                        .|:||..|:    ....:.|.|:......:..||..|:. :.:...:....:|
  Fly   461 ALLCIETLLEGCSVIVFCPSKDWCENLAVQLATAIHVQIKSETVLGQRLRT-NLNPRAIAEVKQQ 524

  Fly   769 VKNTE------LKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVI 827
            :::..      :.:.:.|..|.||||:|..:|.::|..|....::|||:|:||:.||||||..|:
  Fly   525 LRDIPTGLDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVL 589

  Fly   828 IKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNH-----------SELQFYLS 881
            |:     :|..| ..::|:|...||:|||||...||.||.|||.|.           ||||...|
  Fly   590 IR-----SPLFG-GKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITS 648

  Fly   882 LLNQQ---------LPIESQFISKLPD---------MLNAEIVL----------GTVQHLQDAVN 918
            .|:..         |.:.|..::...:         :|:|:...          ....::.||::
  Fly   649 CLDMDGSTHLKRALLEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYINDALD 713

  Fly   919 WLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTA----ACCLERS-----GLIKYD- 973
            :| ..|.::|:.||                  :.|...::.|    |.||..|     |||.:. 
  Fly   714 FL-VEYEFVRLQRN------------------EERETAVYVATRLGAACLASSMPPTDGLILFAE 759

  Fly   974 -RKTGHFQVTDLGRIASH--------YYLTHETMLTYNQLLKQTLSEI-ELFRVFSLSSEFRHIS 1028
             :|:....|.:....|.:        |.|.....|.|..:.::..|.: ::..:..:...|.:.:
  Fly   760 LQKSRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKA 824

  Fly  1029 VREEEKLE---------------LQKLMERVPIPI-----------KESIEEHSAKVNVLLQAYI 1067
            :|.:.||:               |::|:...||.:           .:|:::.::....::.|:.
  Fly   825 LRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFC 889

  Fly  1068 SQLKLEGFAL----------------MSDMVFITQSAARLMRAIFEIVLTRGWAQLAD-KTLTLC 1115
            :.|:....||                :.|::.|...:.:..||:|:..:| ...:||. ..:.|.
  Fly   890 NSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALFDAGIT-SLVELAGADPVELE 953

  Fly  1116 KMIDRRMWQSMTPLRQF-KKMPDEIAKKLEKKHF----------------PWGRLYDLEPHELGE 1163
            |::...:  |....:|. .:..||.||:...::|                ..|.......||:| 
  Fly   954 KVLYNSI--SFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEIG- 1015

  Fly  1164 LIRVPKLG-----------KTIHKFVHQFPKLELSTHI---QPITRGTLRVELTITPDFQWD--- 1211
                  ||           :...:.:|...:::|...:   ||..:..|.:|...|.:.|.:   
  Fly  1016 ------LGTIKWTQTQAGVEIASRAIHDGGEVDLHMSLEEEQPPVKRKLSIEENGTANSQKNPRL 1074

  Fly  1212 EKVHGQSEGFWV------------LIEDVDSE------LILHHEFFLLKQKYSQDEHQLKFFVPV 1258
            |.|.....|:.|            .::::|::      ...|.:..   ...|.|..|....|..
  Fly  1075 ETVVDTQRGYKVDKNIANQSKMNPNLKEIDAQNKARRNSTAHMDNL---NPISNDPCQNNVNVKT 1136

  Fly  1259 FEPLPPQYFLRIVSD----RWIGAETQ-LPVSFRHLI----LPEKNMPPTE-------------- 1300
            .:|        |:|:    :..|::.: :.::...::    |..:..|.|.              
  Fly  1137 AQP--------IISNLNDIQKQGSQIEKMKINPATVVCSPQLANEEKPSTSQSARRKLVNEGMAE 1193

  Fly  1301 -----LLDLQ----------PLPISALRQPKFES-------------------FYSQRFPQFNP- 1330
                 |:.:|          ..||.|.|..:..|                   ..:.:.|:.|| 
  Fly  1194 RRRVALMKIQQRTQKENQSKDQPIQASRSNQLSSPVNRTPANRWTQSENPNNEMNNSQLPRRNPR 1258

  Fly  1331 IQTQVFNA-------VYNSDENVFVG-----APTG-SGKMTIAEFAI------------------ 1364
            .|:.|.||       |.|::|::|:.     ..|| :..:|.||..|                  
  Fly  1259 NQSPVPNANRTASRKVSNAEEDLFMADDSFMLNTGLAAALTAAESKIASCTEADVIPSSQPKEPE 1323

  Fly  1365 -----------------MRLFTTQSDA----RCVYL----------VSEEALADLVFA------- 1391
                             :|....||.:    |.:.:          ||...::|:...       
  Fly  1324 VIGALTPHASRLKRSDQLRSQRIQSPSPTPQREIEIDLESKNESNGVSSMEISDMSMENPLMKNP 1388

  Fly  1392 ---------------DWHSKFGSLDI------------KVVKLTGET------------GTDLKL 1417
                           :..|.|.|:||            .::::...|            |....|
  Fly  1389 LHLNASHIMSCSKVDETASSFSSIDIIDVCGHRNAFQAAIIEINNATRLGFSVGLQAQAGKQKPL 1453

  Fly  1418 IAKGQLV--ITTADKWDVLSRR--------------------------WKQR------------- 1441
            |....|:  :..|:..:..:|.                          |..:             
  Fly  1454 IGSNLLINQVAAAENREAAARERVLFQVDDTNFISGVSFCLADNVAYYWNMQIDERAAYQGVPTP 1518

  Fly  1442 -KNVQLVNLFIVDELQLV---GGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQW 1502
             |..:|.||....:|.||   |.|:..:|.....:::.||:::|             ||: ||.|
  Fly  1519 LKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLKRISAKLE-------------DAK-VANW 1569

  Fly  1503 LGCNPNATFNFHPSVRPIPLE----LHIQGYNVTHNATRIATMSKPVYNAIL---KYSAHKPVIV 1560
            | ..|:.|.||....:....|    .::.|....:::..:.|.|     |||   :.:....|.:
  Fly  1570 L-LQPDKTVNFLNMCQTFAPECTGLANLCGSGRGYSSYGLDTSS-----AILPRIRTAIESCVTL 1628

  Fly  1561 FVSSRKQARLTAI---DVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEG 1622
            .:...:...|:.|   |:|          :|||..|..|:..|.:|      |.:         |
  Fly  1629 HILQGQTENLSRIGNGDLL----------KFFHDIEMPIQLTLCQM------ELV---------G 1668

  Fly  1623 LSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMI 1687
            ..|...|| :||:..   .|||:.:               ::|:.|  :.|.             
  Fly  1669 FPAQKQRL-QQLYQR---MVAVMKK---------------VETKIY--EQHG------------- 1699

  Fly  1688 GRANRPNEDADAKCVLMCQSSK------KDFFKKFINEPLPIESH--LDHRMHDHFNAEVVTKTI 1744
            .|.|..:..|.||.:.:.:.:|      :...:| :|.|:   ||  |.:|......|:.:...:
  Fly  1700 SRFNLGSSQAVAKVLGLHRKAKGRVTTSRQVLEK-LNSPI---SHLILGYRKLSGLLAKSIQPLM 1760

  Fly  1745 ENKQ-DAV--DYLTWTFLYRRLTQNPNYYNLQGVTHRHL----SD--HLSELVENTLSDLEQSKC 1800
            |..| |.:  ..:|:|...|.....|   |||.|.....    ||  |:|  ..:.....::|:|
  Fly  1761 ECCQADRIHGQSITYTATGRISMTEP---NLQNVAKEFSIQVGSDVVHIS--CRSPFMPTDESRC 1820

  Fly  1801 ISVEDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQ 1865
            :...|                   :..:|:..|:..|:.|  .|||::.|:   :|:.:      
  Fly  1821 LLSAD-------------------FCQLEMRILAHMSQDK--ALLEVMKSS---QDLFI------ 1855

  Fly  1866 VLRTLSQRLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRL---QLGPELQGDTEQILSKAIRLI 1927
                                            .:.||.:::   ::..:|:..|:|:        
  Fly  1856 --------------------------------AIAAHWNKIEESEVTQDLRNSTKQV-------- 1880

  Fly  1928 QACVDVLSSNGWLSPAVA---AMELAQMVT----QAMWSKDSYLKQLPHF--SPEIVKRCTEKK- 1982
              |..::...|..|.|.:   :.:.|:|::    ||......|..::.:|  |...|:..|.:: 
  Fly  1881 --CYGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRR 1943

  Fly  1983 -IETV-FDIMELEDEDRTRLLQLSDLQ--MADVARFCNRYPNIELNYEVVDKDRINSGSTVNVVV 2043
             :|.: .|:..|:::...:.:. |.:|  .||:|:  |....:|.|.|...:......::|::|:
  Fly  1944 YLENINSDVEHLKNQAERQAVN-STIQGSAADIAK--NAILKMEKNIERYREKLALGDNSVDLVM 2005

  Fly  2044 QLERE---DEVTGPVIAPFFPQKREEGWWVVIGDPKTNSLLSIKRLTLQQKAKVKL 2096
            .|..|   :..||                      |...:..:..||::...|:.:
  Fly  2006 HLHDELIFEVPTG----------------------KAKKIAKVLSLTMENCVKLSV 2039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(3)72AbNP_648818.3 BRR2 466..1241 CDD:224125 201/968 (21%)
DEAD 482..661 CDD:278688 48/183 (26%)
HELICc 773..859 CDD:197757 34/91 (37%)
Sec63 982..1285 CDD:280962 64/411 (16%)
DEXDc 1320..1506 CDD:214692 56/339 (17%)
DEAD 1329..1495 CDD:278688 49/319 (15%)
HELICc 1615..1694 CDD:197757 14/78 (18%)
Sec63 1811..2127 CDD:280962 49/306 (16%)
DNApol-thetaNP_524333.1 BRR2 209..978 CDD:224125 178/823 (22%)
DEAD 251..404 CDD:278688 45/163 (28%)
HELICc 542..616 CDD:197757 35/79 (44%)
PolA 1489..2055 CDD:223820 137/736 (19%)
DNA_pol_A_theta 1668..2053 CDD:176475 93/512 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466308
Domainoid 1 1.000 45 1.000 Domainoid score I721
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.840

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