DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and Hfm1

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	XP_006535078.1	Gene:	Hfm1 / 330149	MGIID:	3036246	Length:	1476	Species:	Mus musculus

Alignment Length:	1137	Identity:	315/1137 - (27%)
Similarity:	509/1137 - (44%)	Gaps:	239/1137 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 EEARIDHTLHAENLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAA-----DV 294
            ::....:.:|.::..|...:||       :.:...|..|....|:.||:.|.::|.:|     |.
Mouse    88 QKIHFSYNVHEQDYLNLGGSNN-------NDMSHVAGKLMYGSSQKYKNHMGAKSPSARSSPGDT 145

  Fly   295 LKILKDAADDRD------------CENQLVLLLGYDCFDF---------------IKQLKLNRQM 332
            .  |.|.|:||.            |:::      :|| |:               :.|.|::::.
Mouse   146 K--LHDVAEDRQGTSAFKKRLSRTCDSE------HDC-DYADGSLNLSSHISPVKLTQTKISKEN 201

  Fly   333 VLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSEDQEEGEARGSKRGKGDAEDGGAA 397
            ...|     :.:..:||....|.:.|.|.:                    .|..||...:.....
Mouse   202 AWTC-----SNSKQKRQYSTNKFKANDAFS--------------------ASGIGKDIFKAPSFP 241

  Fly   398 AAGQVAGVRQLLELEEMAFTQGSHFMANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQ 462
            ||.|...::.:                     .|:|.                        ..|:
Mouse   242 AASQPHDIQGI---------------------TPNGL------------------------GSLK 261

  Fly   463 PVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENMLLCAPTGAGKT---NVALLTMMREIGKH 524
            .|.::|...:.:|:.|...|.|||:.:...|.:|.|.::|||||:|||   .:|:..::.|:
Mouse   262 AVTEIPAKFRNIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEV--- 323

  Fly   525 INEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQL-TREQIAATQVIVC 588
                 .:...:.||:|:||:|:|..:...::..:.....|...|||||..: ...:|....:|:.
Mouse   324 -----PLPWLNMKIVYMAPIKALCSQRFDDWKEKFGPVGLNCKELTGDTVMDDLFEIQHANIIIT 383

  Fly   589 TPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDE-RGPVLEALVAR--TIRNIETTQEE----- 645
            ||||||.:|||..:.:|:.||||.:|||:|::.|| |||.||.:|:|  |::::....|.
Mouse   384 TPEKWDSVTRKWRDNSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSRDLESASPVP 448

  Fly   646 VRLVGLSATLPNYQDVATFLR--VKPDKGLFYFDNSYRPVSLEQQYIGVTEKKALKRFQ---VMN 705
            ||.|.:|||:||.:|:|.:|.  .:|...| ..|.|:|||.|::..:|.....:...|:   .:|
Mouse   449 VRFVAVSATIPNAEDIAEWLSDGERPAVCL-KMDESHRPVKLQKVVLGFPCSSSQTEFKFDLALN 512

  Fly   706 EIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKEGSASMEV-----LRTE 765
            ..||.....::.:...|||..:||...:.|..:             :|:....:.|     |:..
Mouse   513 YKVYSVIRTYSDQKPTLVFCSTRKGVQQAASVL-------------VKDAKFIISVEQKLRLQKS 564

  Fly   766 AEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKG 830
            |..:::::||:.|.||...|||||...||.|||.||....:.||.:|:|||.|:|:|||.|:||.
Mouse   565 AYSIRDSKLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKS 629

  Fly   831 TQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFIS 895
            |..|:  .|.:.|.|..|:|||:|||||||:||....:::|..|..:.|:.:|.....:||....
Mouse   630 TMHYS--GGVFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTREKYVQMLACNDTVESSLHR 692

  Fly   896 KLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVS----HDAIKA--DPLLEQHRA 954
            .|.:.|||||||.|:..:..|::|:..|.||||.|:||:.||.|    .|.|:|  ..|..::..
Mouse   693 HLIEHLNAEIVLHTITDVNIALDWIRSTMLYIRALKNPSHYGFSSGLNKDGIEAKLQELCLKNLK 757

  Fly   955 DLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLL-KQTLSEIELFRVF 1018
            |        |....|||.|... :|:.|:.||:.:.||:|.||:..:..:. |:||  ::|..:.
Mouse   758 D--------LSSLDLIKMDEDV-NFKPTEAGRLMAWYYITFETVKKFCAISGKETL--LDLISMI 811

  Fly  1019 SLSSEFRHISVREEEKLELQKLME---RVPI--PIKESIEEHSAKVNVLLQAYISQLKLEGFALM 1078
            |..:||..:.:|..||..|..|.:   |:.|  |:.|.|:....|||.|:||.:..:.::.|||.
Mouse   812 SSCNEFLDVQLRISEKRILNTLNKDPNRITIRFPMAERIKTREMKVNCLIQAQLGCIPIQDFALT 876

  Fly  1079 SDMVFITQSAARLMRAIFEIVLT--RGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPDEIAK 1141
            .|.|.|.::.:|:.|.:.:.|..  :.:|.|.:..: |.|....::|::.   :...|..|:|..
Mouse   877 QDTVKIFRNGSRIARWLSDFVAAQEKKFAVLLNSVI-LTKCFKCKLWENS---KHVSKQLDKIGI 937

  Fly  1142 KLEKKHFPWG-----RLYDLEPHELGELI--RVPKLGKTIHKFVHQFPKLELSTHIQPITR-GTL 1198
            .|.......|     ::.:....|| |||  |.|..|..|.:.|...||.||  .::.|.| ..:
Mouse   938 SLSNTMVNAGLTSFKKIEEANAREL-ELILNRHPPFGTQIKEAVAHLPKYEL--EVEQIARYSDI 999

  Fly  1199 RVELTIT---------------PDFQWDEKVHGQSE-----------------GFWVLIEDVDSE 1231
            :.|:.:|               |||.:...:.|.::                 |.||...||...
Mouse  1000 KAEILVTIILRNFEQLQTKRTAPDFHYATLIIGDADNQVVFKHKIMDSVLLKSGNWVKKIDVKRA 1064

  Fly  1232 LILHH-EFFLLKQKY-SQDEHQLKFFVPVFEP 1261
            ||... ...|:...| ..|.|| ||.|..|.|
Mouse  1065 LISEDLSINLISSDYVGLDIHQ-KFTVFYFGP 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	265/851 (31%)
		DEAD	482..661	CDD:278688	69/190 (36%)
		HELICc	773..859	CDD:197757	44/85 (52%)
		Sec63	982..1285	CDD:280962	89/330 (27%)
		DEXDc	1320..1506	CDD:214692
		DEAD	1329..1495	CDD:278688
		HELICc	1615..1694	CDD:197757
		Sec63	1811..2127	CDD:280962
Hfm1	XP_006535078.1	BRR2	263..969	CDD:224125	242/745 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820