DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and Snrnp200

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_001032855.2	Gene:	Snrnp200 / 296126	RGDID:	1561120	Length:	2136	Species:	Rattus norvegicus

Alignment Length:	2153	Identity:	1596/2153 - (74%)
Similarity:	1873/2153 - (86%)	Gaps:	30/2153 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADAAARQLQYEYKANSNLVLQADVRLIERPRRDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTE 65
            |||..||.||||||||||||||||..||:|.||||.||||.||||||:||||||:.|||||:..|
  Rat     1 MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQE 65

  Fly    66 ERKVKRQKRDEAQYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQEALGDQPRD 130
            ||:.||:||||.::|..:|||.|||||||||||||:|:|||:|||:||||||||||.||||||||
  Rat    66 ERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRD 130

  Fly   131 ILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDFGSDAVNALTAAPN 195
            ||||||||:||||||::|:|:||:::||.|||...|.|:.:||||||||||:|.|     ....|
  Rat   131 ILCGAADEVLAVLKNEKLRDKERRREIDLLLGQTDDTRYHVLVNLGKKITDYGGD-----KEIQN 190

  Fly   196 NEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQD--EGEEARIDHTLHAENLANEEAANNVK 258
            .::.||||||:|||||..|||.|.|:|||:|::.:.|  ||:||.:..||.|..:|:.|..::.|
  Rat   191 MDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKK 255

  Fly   259 KERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLKILKDAADDRDCENQLVLLLGYDCFDFI 323
            |:  |||.||||:||||.||:||.||:|||.||.:||:|||.|:|||:||||||||||::.||||
  Rat   256 KD--LHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFI 318

  Fly   324 KQLKLNRQMVLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSED--QEEGEARGSKR 386
            |.|:.:|.|:||||:|||||:::|::||..||..:..|:|.|.||...:.||  :||...|...|
  Rat   319 KVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVR 383

  Fly   387 GKG--------DAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANKRCQLPDGSYRKQRKGYE 443
            ...        |.:.||.|.|     .||:|:||::.|||||||||||||||||||:|:||||||
  Rat   384 QSRMDTDLETMDLDQGGEALA-----PRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYE 443

  Fly   444 EVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENMLLCAPTGAG 508
            |||||||||.||.:.|:|.||:|||||.|..||||||||||||:||:|||::|||:|||||||||
  Rat   444 EVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG 508

  Fly   509 KTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDH 573
            ||||||:.|:||||||||.|||||..||||||:|||:||||||||:||:|||.|.:||:||||||
  Rat   509 KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH 573

  Fly   574 QLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDERGPVLEALVARTIRN 638
            ||.:|:|:|||:|||||||||||||||||||:..||||:::||||||||:|||||||||||.|||
  Rat   574 QLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDDRGPVLEALVARAIRN 638

  Fly   639 IETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSLEQQYIGVTEKKALKRFQV 703
            ||.|||:|||:|||||||||:||||||||.|.|||||||||:|||.|||.|:|:|||||:||||:
  Rat   639 IEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQI 703

  Fly   704 MNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQ 768
            ||||||||.|||||:|||||||||||||||||||:||||||:||||.||:|||||.|||||||||
  Rat   704 MNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQ 768

  Fly   769 VKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQV 833
            .||.|||:|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   769 CKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQV 833

  Fly   834 YNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFISKLP 898
            |:||||||.||.|||:||||||||||||||||||||||:|.|||:||||||||||||||.:||||
  Rat   834 YSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLP 898

  Fly   899 DMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTAACC 963
            ||||||||||.||:.:||||||||.||||||||:|||||:|||.:|.||||:|.|.||:||||..
  Rat   899 DMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALM 963

  Fly   964 LERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLLKQTLSEIELFRVFSLSSEFRHIS 1028
            |:::.|:|||:|||:||||:|||||||||:|::|:.|||||||.|||||||||||||||||::|:
  Rat   964 LDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNIT 1028

  Fly  1029 VREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYISQLKLEGFALMSDMVFITQSAARLMR 1093
            ||||||||||||:||||||:||||||.|||:||||||:||||||||||||:|||::||||.||||
  Rat  1029 VREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMR 1093

  Fly  1094 AIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPDEIAKKLEKKHFPWGRLYDLEP 1158
            |||||||.||||||.||||.||||||:||||||.|||||:|:|:|:.||:|||:||:.|||||..
  Rat  1094 AIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNH 1158

  Fly  1159 HELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHGQSEGFWV 1223
            :|:|||||:||:||||||:||.|||||||.|:|||||.||:|||||||||||||||||.||.||:
  Rat  1159 NEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWI 1223

  Fly  1224 LIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPPQYFLRIVSDRWIGAETQLPVSFRH 1288
            |:||||||:|||||:||||.||:||||.:.||||||||||||||:|:|||||:..||||||||||
  Rat  1224 LVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRH 1288

  Fly  1289 LILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFNPIQTQVFNAVYNSDENVFVGAPTG 1353
            ||||||..||||||||||||:||||...|||.|..:||.||||||||||.|||||:|||||||||
  Rat  1289 LILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTG 1353

  Fly  1354 SGKMTIAEFAIMRLFTTQSDARCVYLVSEEALADLVFADWHSKF-GSLDIKVVKLTGETGTDLKL 1417
            |||...|||||:|:....|:.||||:...||||:.|:.||:.|| ..|:.|||.|||||.|||||
  Rat  1354 SGKTICAEFAILRMLLQNSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKL 1418

  Fly  1418 IAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQLVGGEEGPVLEIVCSRMRYISSQIEK 1482
            :.||.::|:|.:|||:||||||||||||.:|||:|||:.|:|||.|||||::||||||||||||:
  Rat  1419 LGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIER 1483

  Fly  1483 QIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIPLELHIQGYNVTHNATRIATMSKPVYN 1547
            .|||||||:||::|:|||.||||:..:||||||:|||:||||||||:|::|..||:.:|:||||:
  Rat  1484 PIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYH 1548

  Fly  1548 AILKYSAHKPVIVFVSSRKQARLTAIDVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETL 1612
            ||.|:|..|||||||.||||.||||||:||..|:|:|..||.|..|:|:.|:||:::|.||||||
  Rat  1549 AITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETL 1613

  Fly  1613 AQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYED 1677
            ..||.|||||||..:.|||||||.|||:||.|.||.|||||:::||||||||||:||||.|:|.|
  Rat  1614 LNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVD 1678

  Fly  1678 YPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKKFINEPLPIESHLDHRMHDHFNAEVVTK 1742
            |||.|||||:|.||||.:|.:.:||:|||.|||||||||:.||||:||||||.||||||||:|||
  Rat  1679 YPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTK 1743

  Fly  1743 TIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHLSDHLSELVENTLSDLEQSKCISVEDDM 1807
            ||||||||||||||||||||:|||||||||||::|||||||||||||.||||||||||||:||:|
  Rat  1744 TIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEM 1808

  Fly  1808 DTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQVLRTLSQ 1872
            |..||||||||||||||||||||||:|||:|||||||:||||:|||||::.:||||:.:||.|:|
  Rat  1809 DVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQ 1873

  Fly  1873 RLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLGPELQGDTEQILSKAIRLIQACVDVLSSN 1937
            ::|:||..     |||||||:||||||||||||:||..|||.|||:|||||||||||||||||||
  Rat  1874 KVPHKLNN-----PKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSN 1933

  Fly  1938 GWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKKIETVFDIMELEDEDRTRLLQ 2002
            ||||||:||||||||||||||||||||||||||:.|.:||||:|.:|:||||||:|||:|..|||
  Rat  1934 GWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQ 1998

  Fly  2003 LSDLQMADVARFCNRYPNIELNYEVVDKDRINSGSTVNVVVQLEREDEVTGPVIAPFFPQKREEG 2067
            |:|.|:|||||||||||||||:|||||||.|.||..|.|:||||||:|||||||||.||||||||
  Rat  1999 LTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEG 2063

  Fly  2068 WWVVIGDPKTNSLLSIKRLTLQQKAKVKLDFVAPSPGKHDYTLYYMSDSYLGCDQEYKFSIEVGD 2132
            |||||||.|:|||:||||||||||||||||||||:.|.|:||||:|||:|:|||||||||::|.:
  Rat  2064 WWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGHNYTLYFMSDAYMGCDQEYKFSVDVKE 2128

  Fly  2133 FQSESESE 2140
            .:::|:|:
  Rat  2129 AETDSDSD 2136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	632/774 (82%)
		DEAD	482..661	CDD:278688	142/178 (80%)
		HELICc	773..859	CDD:197757	79/85 (93%)
		Sec63	982..1285	CDD:280962	241/302 (80%)
		DEXDc	1320..1506	CDD:214692	126/186 (68%)
		DEAD	1329..1495	CDD:278688	115/166 (69%)
		HELICc	1615..1694	CDD:197757	58/78 (74%)
		Sec63	1811..2127	CDD:280962	251/315 (80%)
Snrnp200	NP_001032855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..80		28/40 (70%)
		Helicase_PWI	254..363	CDD:407980	68/110 (62%)
		BRR2	452..1241	CDD:224125	639/788 (81%)
		DEAH box	615..618		2/2 (100%)
		PRK00254	1310..1897	CDD:234702	421/591 (71%)
		DEXHc_Brr2_2	1325..1515	CDD:350779	129/189 (68%)
		DEAH box	1454..1457		2/2 (100%)
		SEC63	1809..2125	CDD:214744	254/320 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337268
Domainoid	1	1.000	520	1.000	Domainoid score	I294
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	3159	1.000	Inparanoid score	I12
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto96297
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2806
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770