DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Ab and HFM1

DIOPT Version :9

Sequence 1:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster
Sequence 2:	NP_001017975.5	Gene:	HFM1 / 164045	HGNCID:	20193	Length:	1435	Species:	Homo sapiens

Alignment Length:	1197	Identity:	332/1197 - (27%)
Similarity:	546/1197 - (45%)	Gaps:	228/1197 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 NVQFE---ESEEESDND-----------MYGEIRDDDAQDEGEEARIDHTLHAENLANEEAANNV 257
            |:.||   |.|...||:           :..||.|   ..|.||....|.|..:....:...:|:
Human    13 NLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPD---TQELEEELESHKLLGQEKRPKMLTSNL 74

  Fly   258 KKERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLKILKDAADDRDCE----NQLVLLLGYD 318
            |....      |..::.  |::.::.|..|.          |...||.:.|    |.|..:.|
Human    75 KITNE------DTNYIS--LTQKFQFAFPSD----------KYEQDDLNLEGVGNNDLSHIAG-- 119

  Fly   319 CFDFIKQLKLNRQMVLY----CTMLASAQTDSERQRI----REKMRGNSALAKILRQLD-----T 370
                    ||......|    .|.:|..::..:..::    .:|....|...|.|.::.     :
Human   120 --------KLTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGS 176

  Fly   371 GKSEDQEEGEARGS------KRGKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANKRCQ 429
            ..|.|.|.....||      :..||.:.:        .:..:|..:.....||..:.|.|:   :
Human   177 AYSNDNELDSHIGSVKIVQTEMNKGKSRN--------YSNSKQKFQYSANVFTANNAFSAS---E 230

  Fly   430 LPDGSYRKQRKGYEEVHVPALKPV--PFDANE-------ELQPVDKLPKYVQPVFEGFKTLNRIQ 485
            :.:|.::          .|:....  |.|..|       .|:.|.::|...:.:|:.|...|.||
Human   231 IGEGMFK----------APSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQ 285

  Fly   486 SRLYKAALDSDENMLLCAPTGAGKT---NVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSL 547
            |:.:...|.:|.|.::|||||:|||   .:|:..::.|:        .:...:.||:|:||:|:|
Human   286 SKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEV--------PLPWLNIKIVYMAPIKAL 342

  Fly   548 VQEMVGNFGRRLACYNLTVSELTGDHQL-TREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRL 611
            ..:...::..:.....|...|||||..: ...:|....:|:.||||||.:|||..:.:.|.||||
Human   343 CSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRL 407

  Fly   612 VIIDEIHLLHDE-RGPVLEALVAR--TIRNIETTQEE------VRLVGLSATLPNYQDVATFLR- 666
            .:|||:|::.|| |||.||.:|:|  |::::..|.:.      :|.|.:|||:||.:|:|.:|.
Human   408 FLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSD 472

  Fly   667 -VKPDKGLFYFDNSYRPVSLEQQYIGV---TEKKALKRFQVMNEIVYEKTMEHAGRNQVLVFVHS 727
             .:|...| ..|.|:|||.|::..:|.   :.:...|....:|..:......::.:...|||..:
Human   473 GERPAVCL-KMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCAT 536

  Fly   728 RKETGKTARA-VRD----MCLEQDTLGSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHA 787
            ||...:.|.. |:|    |.:||             .:.|:..|..|::::|:::|..|.|.|||
Human   537 RKGVQQAASVLVKDAKFIMTVEQ-------------KQRLQKYAYSVRDSKLRDILKDGAAYHHA 588

  Fly   788 GMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQM 852
            ||...||.:||..|....:.||.:|:|||.|||||||.|:||.|..|  ..|.:.|.|..|:|||
Human   589 GMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHY--AGGLFEEYSETDILQM 651

  Fly   853 LGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAV 917
            :|||||||:||....:::|..|....|:.:|..:..:||.....|.:.|||||||.|:..:..||
Human   652 IGRAGRPQFDTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAV 716

  Fly   918 NWLGYTYLYIRMLRNPTLY----GVSHDAIKADPLLEQHRADLLHTAACCLERSG------LIKY 972
            .|:..|.||||.|:||:.|    |::.|.|:|.  |::          .||:...      |||.
Human   717 EWIRSTLLYIRALKNPSHYGFASGLNKDGIEAK--LQE----------LCLKNLNDLSSLDLIKM 769

  Fly   973 DRKTGHFQVTDLGRIASHYYLTHETMLTYNQLL-KQTLSEIELFRVFSLSSEFRHISVREEEKLE 1036
            |... :|:.|:.||:.:.||:|.||:..:..:. |:|||  :|..:.:...||..|.:|..||..
Human   770 DEGV-NFKPTEAGRLMAWYYITFETVKKFYTISGKETLS--DLVTLIAGCKEFLDIQLRINEKKT 831

  Fly  1037 LQKLME---RVPI--PIKESIEEHSAKVNVLLQAYISQLKLEGFALMSDMVFITQSAARLMRAIF 1096
            |..|.:   |:.|  |::..|:....|||.|:||.:..:.::.|||..|...|.:..:|:.|.:.
Human   832 LNTLNKDPNRITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLS 896

  Fly  1097 EIVLT--RGWAQLADKTLTLCKMIDRRMWQ-SMTPLRQFKKMPDEIA-----------KKLEKKH 1147
            :.|..  :.:|.|.: :|.|.|....::|: |:...:|.:|:...::           ||:|
Human   897 DFVAAQEKKFAVLLN-SLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIE--- 957

  Fly  1148 FPWGRLYDLEPHELGELI--RVPKLGKTIHKFVHQFPKLELSTHIQPITR---GTLRVELT-ITP 1206
                   :.:..|| |||  |.|..|..|.:.|...||.||.  ::.|||   .|..:.:| |..
Human   958 -------ETDAREL-ELILNRHPPFGTQIKETVMYLPKYELK--VEQITRYSDTTAEILVTVILR 1012

  Fly  1207 DFQWDEKVHGQSEGFWV--LIEDVDSELILHHEF---FLLK----QKYSQDEHQLKFFVPVFEPL 1262
            :|:..:.....|:..:|  :|.|.|::::..|:.   .|||    .|....:..||     .|.|
Human  1013 NFEQLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALK-----SEDL 1072

  Fly  1263 PPQYFLRIVSDRWIGAETQLPVSFRHL 1289
            .    :.::|..::|.:.|..::..:|
Human  1073 S----INLISSEFVGLDIQQKLTVFYL 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	264/838 (32%)
		DEAD	482..661	CDD:278688	68/191 (36%)
		HELICc	773..859	CDD:197757	43/85 (51%)
		Sec63	982..1285	CDD:280962	89/337 (26%)
		DEXDc	1320..1506	CDD:214692
		DEAD	1329..1495	CDD:278688
		HELICc	1615..1694	CDD:197757
		Sec63	1811..2127	CDD:280962
HFM1	NP_001017975.5	BRR2	264..970	CDD:224125	243/756 (32%)
		DEXHc_HFM1	280..488	CDD:350781	75/216 (35%)
		DEAH box	411..414		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820