DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and LNX1

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens

Alignment Length:	334	Identity:	72/334 - (21%)
Similarity:	128/334 - (38%)	Gaps:	65/334 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANLRAVPRILRNL 75
            |||::|.|.||...|.|||. ..|.|.:|..|:..:|..:..||:||..|...:.:....::..|
Human    34 EVDDDLICHICLQALLDPLD-TPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKL 97

  Fly    76 LSRLSITCDNAPY--GCTAVLKLDAYNSHLDECIHNPKRPFPCEKGCGFDIPKDELK------DH 132
            |::|.:||   |:  .||.||:......|...         .|:....:.:.||..:      ..
Human    98 LNKLLVTC---PFREHCTQVLQRCDLEHHFQT---------SCKGASHYGLTKDRKRRSQDGCPD 150

  Fly   133 NCVRELRT----------LIVKQTEKMG----ELKSELTDQQLTINELKRELQLFKDFMRAMRV- 182
            .|.....|          .|...|::.|    ...|...|.|..|:.:        |..|:.|.
Human   151 GCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPV--------DSGRSNRTR 207

  Fly   183 SNPAMRAIADQMERDEVIRWSSTLPRARVTRWGGMISTPDDALQLMIKRALSESGCPPHILDSLM 247
            :.|..|:........::.|..|.|.|   |:.|..::...|.     .|..||:...|.:...|.
Human   208 ARPFERSTIRSRSFKKINRALSVLRR---TKSGSAVANHADQ-----GRENSENTTAPEVFPRLY 264

  Fly   248 EFCHERRWPRG-LSSLETRQTNRRIYDNYVCRRIPGKQAVLV-LSCDNLH----MTEDVMIDPGL 306
            ...     |.| ::|::..:.:..  ::...|.:.|.:..|| :...:::    :..|..:.||.
Human   265 HLI-----PDGEITSIKINRVDPS--ESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGD 322

  Fly   307 VMIFAHGIE 315
            :::..:|::
Human   323 IILKVNGMD 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	13/37 (35%)
		Sina	83..>157	CDD:302762	16/95 (17%)
		USP8_interact	137..315	CDD:286082	36/198 (18%)
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693	15/41 (37%)
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693	14/37 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		9/43 (21%)
		NPXY motif	181..184		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244		15/68 (22%)
		PDZ_signaling	272..355	CDD:238492	9/62 (15%)
		PDZ_signaling	380..460	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494
		PDZ_signaling	505..588	CDD:238492
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810