DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment elgi and TRAF7

DIOPT Version :9

Sequence 1:NP_001261904.1 Gene:elgi / 39735 FlyBaseID:FBgn0283649 Length:315 Species:Drosophila melanogaster
Sequence 2:NP_115647.2 Gene:TRAF7 / 84231 HGNCID:20456 Length:670 Species:Homo sapiens


Alignment Length:258 Identity:57/258 - (22%)
Similarity:89/258 - (34%) Gaps:79/258 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANLRAVPRIL 72
            |..:...:|.|.:|..|.:||: ...|.|.|||.|    ..:...||||...||.        ::
Human   121 FAEQPSVKLCCQLCCSVFKDPV-ITTCGHTFCRRC----ALKSEKCPVDNVKLTV--------VV 172

  Fly    73 RNL-----LSRLSITCDNA---------------PYGCTAVLKLDAYNSHLDECIHNPKR----- 112
            .|:     :..|.|.|.:.               |.||...:||.|...|...|.:.|.|     
Human   173 NNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNP 237

  Fly   113 ---PF----------PCEK--------GCGFDIPKDELKDH--NC---------------VRELR 139
               |.          .||.        ||.|...:|..:.|  .|               ..|:.
Human   238 SCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMH 302

  Fly   140 TLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFM--RAMRVSNPAMRAIAD-QMERDEV 199
            ..:.::.:::..|:|.|......|::|::.|:|..|.:  ...::|...|....| .|..||:
Human   303 VALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDEL 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
elgiNP_001261904.1 RING 17..55 CDD:238093 12/37 (32%)
Sina 83..>157 CDD:302762 23/131 (18%)
USP8_interact 137..315 CDD:286082 15/66 (23%)
TRAF7NP_115647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..97
RING 131..163 CDD:214546 12/36 (33%)
Sina 207..>280 CDD:302762 18/72 (25%)
DD_cGKI 282..322 CDD:213458 5/39 (13%)
WD40 <380..668 CDD:225201
WD40 388..668 CDD:238121
WD 1. /evidence=ECO:0000255 394..433
WD 2. /evidence=ECO:0000255 437..474
WD40 repeat 443..477 CDD:293791
WD 3. /evidence=ECO:0000255 477..513
WD40 repeat 482..517 CDD:293791
WD 4. /evidence=ECO:0000255 515..554
WD40 repeat 527..556 CDD:293791
WD 5. /evidence=ECO:0000255 557..594
WD40 repeat 562..596 CDD:293791
WD 6. /evidence=ECO:0000255 597..638
WD40 repeat 604..639 CDD:293791
WD 7. /evidence=ECO:0000255 641..669
WD40 repeat 646..668 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0297
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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