DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elgi and TRAF1

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001177874.1	Gene:	TRAF1 / 7185	HGNCID:	12031	Length:	416	Species:	Homo sapiens

Alignment Length:	345	Identity:	66/345 - (19%)
Similarity:	122/345 - (35%)	Gaps:	93/345 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DVNRFQGEVDEELTCP--ICSGVLEDPLQ-AVMCEHAFCRGCINEWLTRQP------TCP----- 54
            |.|.|      ...||  :|    :||.: ..:|    |.||::|    .|      .||
Human    14 DENEF------PFGCPPTVC----QDPKEPRALC----CAGCLSE----NPRNGEDQICPKCRGE 60

  Fly    55 ----VDRNSLTTANLRAVPRILRNLLSRLSITCDNAPYGCT--------AVLKLDAYNSHLDECI 107
                :...|......:|.|.:     :...|.|..|..||:        ...::.:..|||:..:
Human    61 DLQSISPGSRLRTQEKAHPEV-----AEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLL 120

  Fly   108 HNPKRPFPCEKGCGFDIPKDELKDHNCVRELRTLIVKQTEKMGELKSEL-------TDQQLTIN- 164
            ...|: :....|||.:.....|:.:....:|:..:    |..|:|:.:.       :.::|.:.
Human   121 GFMKQ-WKARLGCGLESGPMALEQNLSDLQLQAAV----EVAGDLEVDCYRAPCSESQEELALQH 180

  Fly   165 --------ELKRELQLFKDFMRAMRVSNPAMR-AIA-----DQMERDEVIRWSSTLPRARVTRWG 215
                    ||:.:|::|::.:..:.....|.. |:|     .|::|:.::....     ||....
Human   181 FMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQ-----RVVELQ 240

  Fly   216 GMISTPDDAL-----QLMIKRALSESGCPPHILDSLMEFCHERRWPRGLSSLETRQTNRRIYDNY 275
            ..::..|.||     .|.:....|..|.....:.::...|||....|.:|.........: |...
Human   241 QTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAK-YGYK 304

  Fly   276 VCRRI------PGKQAVLVL 289
            :|.|:      .||:..|.|
Human   305 LCLRLYLNGDGTGKRTHLSL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	13/55 (24%)
		Sina	83..>157	CDD:302762	16/88 (18%)
		USP8_interact	137..315	CDD:286082	34/186 (18%)
TRAF1	NP_001177874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/15 (27%)
		SMC_N	<140..>263	CDD:330553	21/131 (16%)
		TRAF_BIRC3_bd	184..244	CDD:318808	11/64 (17%)
		MATH_TRAF1	267..413	CDD:239748	13/59 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910