DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and lnx2b

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	287	Identity:	72/287 - (25%)
Similarity:	110/287 - (38%)	Gaps:	74/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GYDVNRF--QGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTAN 64
            |.|.:.|  |.|||:||.|.||...|..|:. ..|.|.:|..|::.:|..|..|||||..:....
Zfish    28 GQDSHLFEYQDEVDDELVCHICLQPLLQPMD-TPCGHTYCFQCLSNFLHDQDFCPVDRQRIQLQQ 91

  Fly    65 LRAVPRILRNLLSRLSITCDNAPYGCTAVLKLDAYNSHLDECIHNPKRPFPCEKGCGFDIPKDEL 129
            .||...::||||.:|::.|                             ||..|  |...:.:.||
Zfish    92 CRASSLLVRNLLDKLAVLC-----------------------------PFRSE--CELSMQRCEL 125

  Fly   130 KDH---NC--VRELRTLIV-KQTEKMGELKSELTDQQLTINELKRELQLFKDFMRAMRVSNPAMR 188
            :.|   .|  .:.||.... |:.....|||...:|..|.      :.:..:...|..::|.|:..
Zfish   126 QPHLHNRCPAFKRLREEAERKKRPSWNELKGSKSDGDLA------DAKSAQTIGRTAQLSAPSEP 184

  Fly   189 AIA----DQMERDEVIRWSSTLPRARVT-------------RWGGMISTP--DDALQLMIKRAL- 233
            .:.    ::.|.|..:| .|.:..|.|.             |..|...||  :..:|.:::.:|
Zfish   185 GLVNPAFEEGEDDTPLR-CSLVAEATVVELFREDPGEDLGLRIVGGKDTPLGNIVIQEIVRDSLV 248

  Fly   234 -SESGCPP--HILD----SLMEFCHER 253
             .:....|  |||:    ||....|.|
Zfish   249 ARDGKLAPGDHILEVNDVSLASISHSR 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	12/37 (32%)
		Sina	83..>157	CDD:302762	15/79 (19%)
		USP8_interact	137..315	CDD:286082	31/145 (21%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546	12/36 (33%)
		PDZ_signaling	210..291	CDD:238492	15/66 (23%)
		PDZ_signaling	325..406	CDD:238492
		PDZ_signaling	451..537	CDD:238492
		PDZ_signaling	587..671	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810