DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elgi and traf6

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001038217.1	Gene:	traf6 / 554561	ZFINID:	ZDB-GENE-030131-5735	Length:	542	Species:	Danio rerio

Alignment Length:	254	Identity:	65/254 - (25%)
Similarity:	102/254 - (40%)	Gaps:	67/254 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GYDVNRFQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWL--TRQPTCPVDRNSLTTAN 64
            |||| .|...::.:..||||...|...:| ..|.|.||..||.:.:  |.| .||||...|....
Zfish    56 GYDV-EFDPPLESKYECPICLMGLRSAVQ-TPCGHRFCDSCIRKSIRDTGQ-KCPVDNEVLLEEQ 117

  Fly    65 LRAVPRILRNLLSRLSITCDNAPYGCTAVLKLDAYNSHLDECIHNPKRPFPCEKGCGFDIP---K 126
            |.......|.:|| |::.|.|  :||:..::|.....||.:|..   ...||.: |...:|   .
Zfish   118 LFPDNFAKREILS-LTVKCSN--FGCSEKMELRQLEKHLSQCRF---ATAPCPQ-CQESVPISHL 175

  Fly   127 DELKDHNCVRELRT---------LIVKQTE--------------KMGELKSEL-----TD----- 158
            ||.|..:|::.:.|         ..|||..              :|..::.:|     ||
Zfish   176 DEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAP 240

  Fly   159 -----------QQLTINELKRELQLF--------KDFMRAMRVSNPAMRAIADQMERDE 198
                       :::|.|||.:.:|.|        .:|:|:..::|..|.:.|..:..|:
Zfish   241 VACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDD 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	15/39 (38%)
		Sina	83..>157	CDD:302762	22/104 (21%)
		USP8_interact	137..315	CDD:286082	20/114 (18%)
traf6	NP_001038217.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..54
		RING	71..108	CDD:214546	15/38 (39%)
		zf-TRAF	205..262	CDD:280357	8/56 (14%)
		MATH_TRAF6	375..521	CDD:239745
		Substrate binding. /evidence=ECO:0000250	489..496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820